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Three drugs: Liraglutide (Saxenda), Semaglutide (Wegovy), and Tirzepatide (Zepbound / Mounjaro) have been licensed for weight loss in patients who are overweight or obese. In this video I will discuss the mechanisms of action of these medicines, the licensed indications, method of administration, efficacy, side effects, and what happens to body weight after stopping treatment. TIMESTAMPS: 00:00 Introduction 00:26 Licensed Drugs 01:37 Mechanisms of Action 05:45 Licensed Indications 06:32 Method of Administration 07:14 Efficacy 08:49 Side Effects 09:47 Stopping Treatment References: Liraglutide: . SCALE Diabetes trial: https://pubmed.ncbi.nlm.nih.gov/26284720/ . SCALE Maintenance trial: https://pubmed.ncbi.nlm.nih.gov/23812094/ . SCALE Obesity & Prediabetes: https://pubmed.ncbi.nlm.nih.gov/26132939/ Semaglutide: . STEP 1 trial: https://pubmed.ncbi.nlm.nih.gov/33567185/ . STEP 2 trial: https://pubmed.ncbi.nlm.nih.gov/33667417/ . STEP 3 trial: https://pubmed.ncbi.nlm.nih.gov/33625476/ . STEP 4 trial: https://pubmed.ncbi.nlm.nih.gov/33755728/ Tirzepatide: . SURMOUNT 1: https://pubmed.ncbi.nlm.nih.gov/35658024/ . SURMOUNT 2: https://pubmed.ncbi.nlm.nih.gov/37385275/ . SURMOUNT 3: https://pubmed.ncbi.nlm.nih.gov/37840095/ . SURMOUNT 4: https://pubmed.ncbi.nlm.nih.gov/38078870/ Liraglutide vs Semaglutide: . STEP 8 trial: https://pubmed.ncbi.nlm.nih.gov/35015037/ What happens to body weight after stopping treatment: . SURMOUNT 4: https://pubmed.ncbi.nlm.nih.gov/38078870/ . STEP 4 trial: https://pubmed.ncbi.nlm.nih.gov/33755728/ . Liver Inte. 2019;39:941-949: https://pubmed.ncbi.nlm.nih.gov/30721572/ Other References: Effect of dual GIP / GLP-1 on Weight loss: https://pubmed.ncbi.nlm.nih.gov/36909312/ This video is purely of educational purposes and is intended for primary care physicians. It is not and should not be used by patients to treat themselves. The advice is to always speak to your doctor and follow his or her advice with regards to any condition you have or any treatment you are likely to undertake. #semaglutide #tirzepatide #wegovyweightloss #mounjaroweightloss #weightlossmedication #saxenda #glp1

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