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Most diet plans now a days focus on cutting carbohydrates to lose weight. Why is this? Are carbohydrates the villainous macro nutrient that is making us fat? Simple logic would tell us we should cut fat when we want to lose body fat. But dietary fat isn't a major determinant of body fat. There are 2 major determining factors when it comes to wanting to lose body fat. First and foremost you have to be in a calorie deficit. The second factor is insulin sensitivity. Now as everything in our bodies insulin is very important it protects our muscles from being used as energy and improves the amino acid absorption into the muscles which helps us to build even more muscle. But there is a flip side. It is also the most fat storing hormone of the body.

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Downsized News: Breakthroughs and Industry Shifts in GLP-1 Treatments In this episode of the Downsized News, Laraine and Christopher Durham deliver the latest updates on GLP-1 medications on Monday, June 2nd, 2025. Key topics include significant data releases by Eli Lilly at the upcoming American Diabetes Association's Scientific Sessions concerning Tirzepatide's effects on kidney function and weight loss compared to Semaglutide. The episode also explores new forms of GLP-1 treatments, such as the Orfroglipron pill and the Retatrutide triple-action hormone, as well as an updated weekly insulin option by Lilly. Additionally, a comprehensive breakdown of a study on high-dose Semaglutide treatments for diabetes and obesity discusses the balance between increased weight loss and rising side effects. The discussion shifts to industry challenges, like Hims Inc.'s layoffs due to FDA crackdowns on compounded GLP-1s, and a new ISSA course designed to help athletic trainers support GLP-1 users. Also covered is the intense industry debate over compounded medications, a major court ruling in India impacting Semaglutide sales, and competitive developments in China's obesity treatment market. The episode concludes with highlights of an innovative partnership between Nxtera Pharma and Eli Lilly aiming at new metabolic treatments. The hosts encourage viewers to stay informed and share personal insights on navigating GLP-1 treatments. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:04 Eli Lilly's Latest Data and Innovations 05:21 High Dose Semaglutide Study Insights 10:14 Hims Layoffs and FDA Crackdown 11:51 New Training Course for GLP-1 Trainers 13:58 Compounded Medications Debate 17:08 Legal Battles and Market Dynamics in India 20:16 NextEra Pharma and Eli Lilly Partnership 21:52 Upcoming Competition in China's GLP-1 Market 24:25 Conclusion and Final Thoughts