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Oral GLP-1 agonists—like oral semaglutide—are poised to transform the future of obesity and type 2 diabetes treatment. But how close are we to seeing these medications approved and widely available? In this video, we explore the following: How close are we to oral GLP-1s? Will we ever see ozempic and mounjaro tablets? If so, when? Will Eli Lilly, Novo Nordisk or someone else be first to market? Links: Pfizer’s press release discontinuing research on their candidate molecule: https://www.pfizer.com/news/press-release/press-release-detail/pfizer-provides-update-oral-glp-1-receptor-agonist Eli Lilly’s April press release on Orfoglipron https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically#:~:text=News%20Release-,Lilly's%20oral%20GLP%2D1%2C%20orforglipron%2C%20demonstrated%20statistically%20significant%20efficacy,orforglipron%20worldwide%20without%20supply%20constraints. And their follow-up press release on having these results prublished in the New England Journal of Medicine: https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-showed-compelling-efficacy-and#:~:text=Lilly's%20oral%20GLP%2D1%2C%20orforglipron,Medicine%20%7C%20Eli%20Lilly%20and%20Company NovoNordisk’s progress as of May 2025: https://www.reuters.com/sustainability/boards-policy-regulation/us-fda-accepts-novo-nordisks-application-oral-wegovy-2025-05-02/ Animal study linking *liraglutide* with thyroid cancer, suggesting it may be species-specific https://academic.oup.com/endo/article-abstract/151/4/1473/2456651?redirectedFrom=fulltext&login=false Timestamps: Timeline for getting a new drug to market [00:28] Who is developing oral GLP-1 agonists? [01:22] Eli Lilly - Orforglipron [02:22] Novo Nordisk - Rybelsus (semaglutide) and NN-9932 [04:42] What else is brewing (“The best of the rest”) [06:11] Okay, so you’ve hear a little something about ozempic, wegovy and the gang, a group of utterly revolutionary large molecules that can help aid in really significant weight loss through a series of injections helping to curb appetite and slow gastric emptying, making you feel fuller for longer, wouldn’t it be neat if this came as a tablet? Eli Lilly and Novo Nordisk think so. Eli Lilly, producer of Mounjaro and Zepbound has one drug in Phase III trials, orforglipron, with results coming out from last month and expected to keep rolling in for the rest of the year and the start of next. After which, we may see it launched as an oral medication for both diabetes and weight loss Novonordisk, already has an oral medication FDA approved but only for the management of diabetes, Rybelsus Eli Lilly have over 6,000 people enrolled in ACHIEVE phase 3 trial that is investigating orforglipron as a diabetes medicine and intend to publish the rest of the data in late 2025 and 2026. They are also running their phase 3 trials investigating its efficacy as a weight management drug under the name ATTAIN and expect to submit to the FDA and other global regulatory bodies before the end of 2025, meaning that if the trials continue to come in with positive results and the FDA are happy, Eli Lilly will be bringing an oral weight loss drug to market around the middle of 2026. as for Novo, they’ve been a lot quieter with their press releases of late Rybelsus, its an oral formulation of Novo Nordisk’s semaglutide molecule, which has proven itself effective time and time again in injection form under brands, Ozempic and Wegovy. Its already out there in the US and Europe and works, though the weight loss effects appear to be about half that of Wegovy. clinical studies have found that increasing the dose increases the weight loss achieved, with one 68-week study finding a 50mg daily oral dose led to 15% weight loss, again, linked down below. the best of the rest: On April 14, Pfizer announced the termination of the development of an attempt at an oral obesity medication after the molecule, named danuglipron, was found to damage the livers of a participant of a phase 2 trial. HRS9531, published their phase 2 trial outcomes in June 2024, finding that, in a study of 249 patients a 6.0mg INJECTION lead to an average weightloss of 16% in just 26 weeks in obese, non-diabetic participants. The phase two trial is linked down below https://diabetesjournals.org/diabetes/article/73/Supplement_1/1861-LB/155203/1861-LB-Efficacy-and-Safety-of-HRS9531-a-Novel Both Eli Lilly and Novo Nordisk are near the final hurdle, so, oral weight loss medications of the GLP-1 agonists may be arrive early 2026. ** All the information contained in this video is not intended nor implied to constitute professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general informational purposes only and does not replace a consultation with your own doctor/health professional **

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The keto diet has been a popular weight loss trend in recent years, with many people turning to it as a way to shed excess pounds and improve their overall health. While the keto diet can be effective, it can also be difficult to stick to, especially for those who have busy lifestyles or who struggle to maintain the strict dietary restrictions required by the diet. That’s where supplements like Keto Blast Gummies by Doctor Juan come in.

The Science Behind Keto Blast Gummies

Keto Blast Gummies are a dietary supplement that aims to support those following a ketogenic diet by providing them with an easy and convenient way to stay in ketosis. Ketosis is a metabolic state in which the body burns fat for energy instead of carbohydrates, leading to weight loss. By providing the body with exogenous ketones, Keto Blast Gummies can help jumpstart ketosis and keep it going, even if the person takes in a few more carbs than recommended.

One of the key ingredients in Keto Blast Gummies is beta-hydroxybutyrate (BHB), which is a type of exogenous ketone. BHB helps increase the level of ketones in the blood, which can help the body reach ketosis faster and stay there longer. This can lead to increased fat burning, improved energy levels, and better mental clarity.

Additionally, Keto Blast Gummies contain other natural ingredients such as MCT oil, which is known for its ability to boost ketone production and support weight loss. MCT oil is easily converted into ketones by the liver, making it a valuable addition to the formula. These ingredients work together to support the body’s ketogenic state and help users experience the full benefits of the keto diet.

Benefits of Keto Blast Gummies

There are several benefits to using Keto Blast Gummies as part of a ketogenic diet. One of the main advantages is the convenience they offer. Instead of having to prepare and cook keto-friendly meals, users can simply take a few gummies each day to help them stay on track with their weight loss goals. This can be especially helpful for those with busy schedules or who struggle to find time to cook healthy meals.

Another benefit of Keto Blast Gummies is their ability to increase energy levels. When the body is in ketosis, it burns fat for fuel instead of carbohydrates, which can lead to a more steady and sustained energy level throughout the day. By providing the body with exogenous ketones, Keto Blast Gummies can help users avoid the energy crashes that are often associated with traditional diets high in carbohydrates.

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Furthermore, Keto Blast Gummies can help improve mental clarity and focus. Many users report feeling more alert and focused when they are in ketosis, which can be attributed to the brain’s use of ketones for energy. By supporting the body’s ketogenic state, Keto Blast Gummies can help users experience improved cognitive function and mental performance.

How to Incorporate Keto Blast Gummies into Your Routine

For those interested in trying Keto Blast Gummies, it’s important to follow the recommended dosage instructions provided on the packaging. Typically, users are advised to take 2-4 gummies per day, depending on their individual needs and goals. It’s also important to continue following a ketogenic diet while taking the supplement, as this will help maximize the benefits of the product.

In addition to taking Keto Blast Gummies, it’s also important to stay hydrated and engage in regular exercise to support weight loss and overall health. Staying hydrated can help the body flush out toxins and waste products, while exercise can help increase fat burning and improve muscle tone. By combining Keto Blast Gummies with a healthy lifestyle, users can experience even better results and achieve their weight loss goals more quickly.

Overall, Keto Blast Gummies by Doctor Juan offer a convenient and effective way to support a ketogenic diet and achieve weight loss goals. By providing the body with exogenous ketones and other natural ingredients, these gummies can help users reach ketosis faster, stay in ketosis longer, and experience the full benefits of the keto diet. Whether you’re new to the keto diet or looking for a way to boost your results, Keto Blast Gummies could be the perfect solution for you.

Potential Side Effects and Risks

It’s important to note that while keto diet supplements like Keto Blast Gummies can be effective for weight loss and overall health, they may also come with some potential side effects and risks. Some users may experience digestive issues such as bloating, gas, or diarrhea when first starting the supplement, as the body adjusts to the new ingredients. Additionally, individuals with certain medical conditions or allergies should consult with a healthcare provider before taking Keto Blast Gummies to ensure they are safe for them to use.

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Another important consideration is the potential for overconsumption of exogenous ketones. While taking Keto Blast Gummies can help support ketosis, taking too many gummies or exceeding the recommended dosage can lead to an imbalance of ketones in the blood, which can have negative effects on the body. It’s essential to follow the dosage instructions provided and not exceed the recommended amount to avoid any potential risks or side effects.

Overall, while Keto Blast Gummies can be a valuable tool for those following a ketogenic diet, it’s important to use them responsibly and in conjunction with a healthy lifestyle. By being mindful of potential side effects, risks, and the importance of following recommended dosage instructions, users can safely incorporate Keto Blast Gummies into their routine and experience the full benefits of the supplement.

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Does your body resist weight loss? If so, then a ketogenic diet is worth a look. In this video, we explain what a ketogenic diet (a.k.a. keto diet) is and why it works when other diets fail. Dr. Keith is on week 27 of following a ketogenic diet. We have recorded his progress (Catch up on his amazing results by watching Keith's Progress here: http://www.youtube.com/2FitDocs) In this video, you'll learn How a keto diet changes your body from a sugar-burning metabolism to a fat-burning metabolism. How a keto diet stabilizes your energy level for all-day energy. Take our 21-Day KETO Challenge and get daily keto menus sent to your email inbox! https://www.drbeckyfitness.com/21-day-keto-challenge/ Get started with our Free Starter Kit (includes our 0,1,2,3 Strategy): https://www.drbeckyfitness.com/get-started/ Want more? Join our Freedom Weight Loss Coaching Program: https://www.drbeckyfitness.com/weight-loss-coaching-program-fhp-2/ Get Dr. Becky's book on Amazon or your favorite retailer: https://www.drbeckyfitness.com/book Want to throw a party AND stick with your Keto Diet? Grab our Keto Party Plan (delicious) https://www.drbeckyfitness.com/2-fit-docs-keto-party/ For Products Shown in our Videos: http://www.amazon.com/shop/beckygillaspy (affiliate/paid link) Link to Dr. Becky's 2nd YouTube Channel: https://www.youtube.com/beckygillaspy More Videos: 5 Keto Tips for The Over 50 Crowd https://youtu.be/k-trjdvzEqw Top 10 Foods to Get Keto-Adapted Quickly: https://youtu.be/0xdtw8bCQb0 Dr. Keith's Complete Transformation: http://bit.ly/2Gjn4Uw Definitive Test! What Can I Put in Coffee When Intermittent Fasting? http://bit.ly/2HHbwdr ******************** Disclaimer: Dr. Becky Gillaspy, DC received her Doctor of Chiropractic degree from Palmer College of Chiropractic in 1991. Her use of “doctor” or “Dr.” in relation to herself solely refers to that degree. Dr. Gillaspy was a licensed chiropractor in Pennsylvania, but she no longer practices chiropractic in any state and does not see patients. Dr. Keith Gillaspy, DC, CFMP received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1991. He also completed 300 hours of post-graduate study resulting in his certification in Functional Medicine. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Gillaspy is a licensed chiropractor in Pennsylvania and continues to practice in Pennsylvania and see patients. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Gillaspy and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Dr. Becky Fitness LLC and Drs. Rebecca Gillaspy, D.C. and Dr. Keith Gillaspy, D.C. are not liable or responsible for any advice, course of treatment, diagnosis, or any conclusions drawn, services, or product you obtain through this video or site.

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Fala minha gente, tudo certo com vocês? No vídeo de hoje vamos entender como um distúrbio na liberação de GLP-1, um hormônio liberado por células neuroendócrinas L do nosso intestino, prejudica a absorção de glicose sanguínea, uma vez que não vai estimular a liberação de insulina por parte do pâncreas. E aí? Curtiu? Então te inscreve no canal e me segue nas redes sociais: TikTok: @profdiegoreinicke Instagram: @profdiegoreinicke Comenta aqui em baixo o que você achou. Não esqueça de se inscrever nesse canal (https://www.youtube.com/channel/UCA4CLNhK8Z6QHTErIkKMyvw?sub_confirmation=1). Isso ajuda muito no crescimento e na divulgação de conteúdos como esse. Bons estudos e até a próxima. 😁 OBS: Se você precisa de roupas, tênis e outros artigos de vestuário, clique nesse link https://jmstoreoficial.com.br e coloque o meu CUPOM: Dieguinho para receber um desconto especial. GLP-1 e o seu Papel na Glicemia (Parte 2) - Prof. Diego Reinicke