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This is the story of how GLP-1 receptor agonist drugs like semaglutide and tirzepatide were developed. Support my work on Nebula: https://go.nebula.tv/patrickkelly ☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️ 🎬C R E D I T S🎬 Written, performed, and edited by Patrick Kelly Select imagery/video supplied by Getty Images Thank you to Dr. Svetlana Mojsov and Rockefeller Institute for the use of Dr. Mojsov's portrait 🔗 L I N K S 🔗 📱Instagram: https://www.instagram.com/patkellyteaches/ 💰Patreon: https://www.patreon.com/corporis 🔬Old channel: www.youtube.com/corporis/ 📚Book recommendations: www.patkellyteaches.com/books 🔑 P A T R O N S 🔑 Oxytocin Tier: Mike W | Paul R | Daphnanne P | Oliver W | Tal Globus | Paul Belmes Growth Hormone Tier: Carey & Jack P | Brendan P | Brandon K | Kristofer R | Joe B | Mindi F | Michael G | Brian B | Eileen H | Waffles the Dog | Brian T | Brian H | Michael R | Karen S | Sarah B | Robin B | Jacob S | Hyeon-Seo | Paul! | Lucy Fur | Huynhy | Jim C | elnombre91 | Alcedo | Josef K | Dab B | Robert M | Jiggs | TierZoo | Seth G | Jane G | Jack M | Matthew B | Michelle J | Helena SB | Eric L | Ryne J | Kilian | Dean M | Cody S | Michelle L | Joseph G | Aryan R | Vic K | Becca | Jesse B | Stella | Marc M | Roxanna A | Doyle V | Maria A | Karen S | Jon A | Brian | Blake | Caitlin E | David W | DrCredibleHulk | Eugene F | Anthony DiF | Charlie C | Reniece J | chris | Rachel J | ZoeMarie | Katie B-S | Broderic D | CJ 📜 S O U R C E S 📜 An annotated version of the script can be found on Patreon: https://www.patreon.com/posts/glp-1-video-133601476?utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=postshare_creator&utm_content=join_link Novo Nordisk (2023) by Kurt Jacobsen The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity (2024) https://www.pnas.org/doi/10.1073/pnas.2415550121 Glucagon as the First Incretin: Objects (in the Rearview Mirror) Are Closer Than They Appear (2023) https://diabetesjournals.org/diabetes/article/72/12/1739/153849/Glucagon-as-the-First-Incretin-Objects-in-the The development of Byetta (exenatide) (2012) https://www.sciencedirect.com/science/article/pii/S0041010110004472 The time has come for incretins, a long time coming (2010) https://link.springer.com/content/pdf/10.1007/s00109-009-0586-5.pdf Dual GIP–GLP1-Receptor Agonists In The Treatment Of Type 2 Diabetes: A Short Review On Emerging Data And Therapeutic Potential (2019) https://www.dovepress.com/article/download/48870 Type 2 Diabetes https://diabetesatlas.org/media/uploads/sites/3/2025/02/IDF-Atlas-2nd-Edition.pdf https://diabetes.org/about-diabetes/type-1 https://www.ncbi.nlm.nih.gov/books/NBK507839/ https://www-sciencedirect-com.harker.idm.oclc.org/science/article/pii/S0169409X02000935?via%3Dihub FDA Shortages: https://www.fda.gov/media/185526/download?attachment 💻 C O N T A C T 💻 patkellyteaches [at] gmail.com ⌛T I M E S T A M P S ⌛ 0:00 intro 0:52 GLP-1 as a hormone 9:50 GLP-1 as a diabetes drug 13:00 exenatide 16:21 liraglutide 19:20 GLP-1 as an obesity drug 24:25 dulaglutide 25:23 semaglutide 28:40 tirzepatide 30:45 Compounding pharmacies 33:26 Conclusion #historyofmedicine #medicalhistory

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