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Check out Hers's YouTube Channel: https://m.youtube.com/@forhers The system wasn’t built to help us. It was designed to keep us sick & stuck. It offers one-size-fits-all solutions that ignore your needs and fail to deliver lasting results. It restricts access to care with red-tape and inflated prices, and obscures the truth while downplaying the dangers of keeping us overweight. At Hims & Hers, we’re fighting back. We offer weight loss care that’s accessible, affordable, and doctor-trusted. Care that’s tailored to your needs for long-term success. Care that prioritizes your health and safety above all else. Care that makes you feel great in your body—because that’s what you deserve. Join us in the fight for a healthier America at https://www.forhers.com/healthier-america Subscribe to Hers on YouTube: https://www.youtube.com/channel/UCkEdiHcUZjzs8IqO2j4jhaA Prescription required. Compounded drug products are not FDA approved. The FDA does not evaluate compounded drug products for safety, effectiveness, or quality. Not available in all 50 states. Weight Loss by Hims & Hers is a holistic program that includes nutrition support, technological tools, and medication kits including customized compounded medications or compounded GLP-1 injections, prescribed based on what your provider determines is medically appropriate for you. See website for details and important safety information. Connect with Hers on social: Facebook: https://www.facebook.com/wearehers X: https://x.com/wearehers Instagram: https://www.instagram.com/hers TikTok: https://www.tiktok.com/@hers

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GLP-1 medications like Zepbound aren’t just about weight loss—they’re addressing serious medical conditions like Sleep Apnea, Heart Disease, and Diabetes. Yet, society still reduces them to 'quick fixes' for vanity." In this episode, we’ll unpack the science, the stigma, and the societal shift that needs to happen. Save Your Spot for the Retreat Here: 👉👉👉https://brilliantandfit.my.canva.site/2025-brilliant-f-i-t-fearless-inspired-transformed-retreat You can also email me at: [email protected]

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Obesity, a driver of inflammation, is prevalent in patients with HFpEF. Ileana Pina asks Ambarish Pandey about GLP-1 inhibitors and SGLT2 inhibitors in HFpEF. Are these drugs anti-inflammatory? https://www.medscape.com/viewarticle/993980?src=soc_yt -TRANSCRIPT- Ileana L. Piña, MD, MPH: Hello, everyone. I'm Ileana Piña, professor of medicine at Jefferson University Hospital in Philadelphia. I'm the chief of quality. This is my blog. We have been hearing a lot of conversation about obesity. It's coming out of our endocrine division and our weight management division. And the patients are asking for things like bariatric surgery and maybe a holistic program of weight loss. A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. We see more younger folks with obesity in our HFpEF clinic coming in with symptoms of shortness of breath and fluid buildup. Our understanding of HFpEF has evolved quite a bit over the past two or three decades. Initially, it was thought to be a disease of largely impaired myocardial relaxation. And then Walter Paulus was one of the pioneers who proposed the concept of inflammation leading to HFpEF, and obesity being one of the important drivers of the inflammation that leads to the development of HFpEF. Now our understanding of HFpEF has evolved to it being a multisystem disorder that leads to dysfunction in different organ systems. One of the cardinal features that drives this dysfunction is upregulation of inflammatory pathways, increased inflammatory burden — and a lot of that is driven by obesity. Obesity is one of the most important modifiable risk factors for HFpEF. Piña: It is so common. In my clinic the other day, probably 3 out of 4 patients were obese. Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. And if you look at the data from the STEP trials that were done, looking at weight loss effects of semaglutide, a commonly used GLP-1 inhibitor, there was a good 30%-40% reduction in CRP levels, and that suggests that there is a significant anti-inflammatory effect. Now, whether it's a direct effect on anti-inflammatory pathways or is related to weight loss is a matter of debate. Piña: Are you using GLP-1 inhibitors in your HFpEF clinic? And what trials can we look forward to seeing concerning the use of these agents? https://www.medscape.com/viewarticle/993980?src=soc_yt

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In this video you're gonna learn how to lose belly fat by sleeping more based on the latest research. ►If you found this video helpful hit Subscribe to support the channel and share the video with your friends to spread the word◄ Key points: 1 - Sleeping More While in a Caloric Deficit Allows You To Burn More Fat And Keep More Muscle Study University of Chicago https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951287/ Study compared 8.5-hours-in-bed phase vs In the 5.5-hour phase Cutting back on sleep to 5.5 hours reduced fat loss by 55 percent. The number of calories they consumed was about ~1450 per day. Lost an average of 6.6 pounds during each 14-day session. During weeks with enough sleep, they lost 3.1 pounds of fat and 3.3 pounds of lean body mass. During the 5 hour sleep weeks participants lost an average of 1.3 pounds of fat and 5.3 pounds of fat-free mass. Lesson: While in a caloric deficit a sufficient amount of sleep helps you retain more muscle mass and lose more fat. 2 - Sleeping More Will Help You Be Less Hungry The same University of Chicago study checked ghrelin levels. During those weeks of 5.5 hours in bed the ghrelin levels of participants rose from 75 ng/L to 84 ng/L. Ghrelin is a hormone that increases appetite, and also plays a role in body weight. A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. https://www.ncbi.nlm.nih.gov/pubmed/18564298 Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535701/ Higher ghrelin levels have been shown to reduce energy expenditure, stimulate hunger and food intake, promote retention of fat and increase hepatic glucose production to support the availability of fuel to glucose dependent tissues. Research study https://press.endocrine.org/doi/abs/10.1210/jc.2004-1003 found that sleeping less than 6 hours triggers the area of your brain that increases your need for food while also depressing leptin (satiety hormone) and stimulating ghrelin (hunger hormone). 3 - Lack of Sleep Reduces Your Self-Control and Willpower to Fight Off Cravings Study published in Nature Communications found that a single night of sleep deprivation can impair activity in your frontal lobe, which controls complex decision-making. https://www.nature.com/ncomms/2013/130806/ncomms3259/full/ncomms3259.html Additionally lack of sleep increases your cortisol levels. And that also activates reward centers in your brain that make you crave food A combination of high ghrelin and cortisol shut down the areas of your brain that leave you feeling satisfied after a meal, meaning you feel hungry all the time, even if you just ate a big meal. Additionally Lack of sleep diminishes mental clarity to make good complex decisions, specifically with regards to the foods you eat—or foods you want to avoid. When we get tired we have increased activity in the amygdala, the reward region of your brain. This is one of the reasons why sleep deprivation destroys all adherence to a diet. It makes you crave very high-calorie foods. When rested you can greatly fight off this desire, but because your insular cortex (another portion of your brain) is weakened due to sleep deprivation, you have trouble fighting the urge and are more likely to indulge in all the wrong foods. Lastly a research published in Psychoneuroendocrinology found that sleep deprivation makes you select greater portion sizes of all foods, further increasing the likelihood of weight gain. https://www.sciencedirect.com/science/article/pii/S0306453013000176 4 - Sleep Sabotages Your Gym Time Scientists from Brazil in 2011(https://www.ncbi.nlm.nih.gov/pubmed/21550729) found that sleep debt decreases protein synthesis which causes muscle loss. Lack of sleep makes it harder for your body to recover from exercise by slowing down the production of growth hormone which is your natural source of anti-aging and fat burning that also facilitates recovery. The already reduced production of growth hormone due to lack of slow wave sleep is further reduced by more cortisol in your system. It's a very bad cycle with 1 simple solution: Get more sleep. As usual post your questions in the comments below! Talk soon, Mario For more check out: Facebook: https://www.facebook.com/MarioTomicOfficial Instagram: https://instagram.com/mariotomich Website: https://www.tomic.com Music used: DEAF KEV - Invincible https://www.youtube.com/watch?v=J2X5mJ3HDYE Facebook https://www.facebook.com/officialDEAFKEV YouTube https://www.youtube.com/user/ATMDubstep

What Ozempic Weight Loss Drugs Really Do To The Body

Are you on Ozempic®, Wegovy®, or another GLP-1 med? These drugs are changing lives—but many users aren’t told about the gut side effects. 👉 14% report diarrhea. 7% end up constipated. But it’s not just about symptoms—it’s about why it happens. In this episode, colorectal surgeon Dr. Carmen Fong breaks down what GLP-1s do to your gut: ✔️ Slowed motility ✔️ Increased water absorption ✔️ Decreased appetite ✔️ Reduced nutrient intake This trifecta can mean rock-hard stools, explosive diarrhea, or both—especially when paired with low-fiber meals. 💩 If you’re struggling with bowel habits while on GLP-1s, it’s not just you—and there are ways to support your gut. 🎧 Visit IBSdietitian.com/podcast to listen to the full episode.

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How Glp1 Medications Revolutionize Weight Loss In Two Minutes Aestheticmedicine

In this video, I'll guide you through a powerful morning routine that will help you burn belly fat, tone your waist, and develop strong abdominal muscles — all by doing simple exercises on an empty stomach! These exercises are quick, effective, and require no equipment, making them perfect for anyone looking to kickstart their day with a fat-burning workout. 1. **Clap Your Hips 100 Times**: This exercise activates your core and helps tighten your belly. By doing it daily on an empty stomach, you'll stimulate fat loss around your midsection, leading to a flatter belly over time. 2. **Knee Raises 100 Times**: This moves targets the stubborn fat on the sides of your waist, helping you slim down your love handles. It’s simple but effective for slimming your waistline and improving core strength. 3. **Opposite Knee Raises 100 Times**: This exercise helps tighten and tone your entire abdominal area. By engaging both your upper and lower abs, you'll start developing a defined abdominal line and even see the beginnings of your vest lines! 4. **Freehand Squats 100 Times**: Not only do squats help tone your legs, but they also boost your metabolism and continue to burn fat even after your workout is over. It’s a great way to keep your body in fat-burning mode throughout the day. Follow along with these 4 simple exercises and do them consistently for the best results. Whether you’re just starting your fitness journey or are looking for a quick morning routine to fit into your busy schedule, this workout will get you closer to your fitness goals! Don’t forget to like, subscribe, and hit the notification bell for more fitness tips and routines! Burn Belly Fat Tone Waist Abdominal Muscles Morning Routine Fat Burning Exercises Clap Your Hips Knee Raises Slim Waistline Core Exercises Vest Lines Freehand Squats Home Workout No Equipment Workout Quick Fat Burning Beginner Fitness Stubborn Fat Abs Workout Flat Belly Weight Loss Exercises Fitness Motivation #BurnBellyFat #ToneWaist #AbdominalMuscles #MorningRoutine #FatBurningExercises #ClapYourHips #KneeRaises #SlimWaistline #CoreExercises #VestLines #FreehandSquats #HomeWorkout #NoEquipmentWorkout #QuickFatBurning #BeginnerFitness #StubbornFat #AbsWorkout #FlatBelly #WeightLossExercises #FitnessMotivation