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In this episode, my guest is Dr. Zachary Knight, Ph.D., a professor of physiology at the University of California, San Francisco (UCSF), and Howard Hughes Medical Institute (HHMI) investigator. We discuss how the brain controls our sense of hunger, satiety, and thirst. He explains how dopamine levels impact our cravings and eating behavior (amount, food choices, etc) and how we develop and can change our food preferences and adjust how much we need to eat to feel satisfied. We discuss factors that have led to the recent rise in obesity, such as interactions between our genes and the environment and the role of processed foods and food combinations. We also discuss the new class of medications developed for the treatment of obesity and diabetes, including the GLP-1 agonists semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro). We discuss how these medications work to promote weight loss, the source of their side effects, and the newer compounds soon to overcome some of those side effects, such as muscle loss. Dr. Knight provides an exceptionally clear explanation for our sense of hunger, thirst, and food cravings that translates to practical knowledge to help listeners better understand their relationship to food, food choices, and meal size to improve their diet and overall health. Access the full show notes, including referenced articles, books, people mentioned, and additional resources: https://www.hubermanlab.com/episode/dr-zachary-knight-the-science-of-hunger-medications-to-combat-obesity Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter Dr. Zachary Knight UCSF academic profile: https://profiles.ucsf.edu/zachary.knight HHMI profile: https://www.hhmi.org/scientists/zachary-knight Publications: https://knightlab.ucsf.edu/publications Lab website: https://knightlab.ucsf.edu X: https://x.com/zaknight Instagram: https://www.instagram.com/zknightsf LinkedIn: https://www.linkedin.com/in/zachary-knight-29a37977 Timestamps 00:00:00 Dr. Zachary Knight 00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up 00:07:07 Hunger & Timescales 00:11:28 Body Fat, Leptin, Hunger 00:17:51 Leptin Resistance & Obesity 00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons 00:30:26 Sponsor: AG1 00:32:15 Body Weight & Obesity, Genes & POMC Neurons 00:39:54 Obesity, Genetics & Environmental Factors 00:46:05 Whole Foods, Ultra-Processed Foods & Palatability 00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning 00:58:55 Calories vs. Macronutrients, Protein & Salt 01:02:23 Sponsor: LMNT 01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure 01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy 01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea 01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects 01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133 01:34:49 Alpha-MSH & Pharmacology 01:40:41 Dopamine, Eating & Context 01:46:01 Dopamine & Learning, Water Content & Food 01:53:23 Salt, Water & Thirst 02:03:27 Hunger vs. Thirst 02:05:46 Dieting, Nutrition & Mindset 02:09:39 Tools: Improving Diet & Limiting Food Intake 02:14:15 Anti-Obesity Drug Development 02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter #HubermanLab #Health #Obesity Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://www.hubermanlab.com/disclaimer
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Embarking on a new diet or lifestyle change can be challenging, which is why community support is crucial for success. The Keto Blast website features a vibrant and supportive community of like-minded individuals who are all on their own keto journey. Whether you’re looking for advice, motivation, or simply a friendly ear to listen, the Keto Blast community is there for you.
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While the keto diet is relatively straightforward, navigating the ins and outs of ketosis, macros, and meal planning can be overwhelming for beginners. That’s where the expert guidance on the Keto Blast website comes in. With a team of experienced nutritionists, dietitians, and keto experts on hand, you can get the personalized support and advice you need to succeed on your keto journey.
From personalized one-on-one coaching sessions to informative articles and webinars, the expert guidance on Keto Blast covers all aspects of the keto diet, from the science behind ketosis to practical tips for meal prep and grocery shopping. Whether you’re looking to troubleshoot a weight loss plateau or optimize your macros for better results, the expert guidance on Keto Blast can help you reach your goals.
With evidence-based information and practical tips tailored to your individual needs, the expert guidance on the Keto Blast website can help you navigate the challenges of the keto diet with confidence and ease.
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With so many keto products flooding the market, it can be challenging to separate the hype from the reality. That’s where the product reviews and recommendations on the Keto Blast website come in. From snacks and supplements to kitchen gadgets and meal delivery services, Keto Blast offers honest and unbiased reviews of a wide range of keto products, helping you make informed decisions about what to buy and what to skip.
Each product review on the Keto Blast website is written by a team of experts who have tested the products themselves and can provide valuable insights into their taste, quality, and value for money. Whether you’re looking for a delicious keto-friendly snack to satisfy your cravings or a convenient meal delivery service to save you time in the kitchen, the product reviews on Keto Blast can help you make smart choices that align with your keto goals.
With detailed comparisons, pros and cons lists, and real-life experiences shared by the Keto Blast team, you can shop with confidence and discover new keto products that can enhance your keto experience and support your overall health and wellness.
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While the keto diet is a powerful tool for weight loss and overall health, incorporating regular physical activity into your routine can amplify your results and improve your overall well-being. The Keto Blast website offers a range of workout plans and fitness tips designed to help you stay active, build strength, and boost your metabolism while following a keto lifestyle.
From beginner-friendly workouts you can do at home to advanced gym routines that target specific muscle groups, the workout plans on Keto Blast cater to all fitness levels and goals. Whether you’re looking to burn fat, build muscle, or simply improve your cardiovascular health, you’ll find plenty of options to help you get moving and stay motivated on your fitness journey.
In addition to workout plans, the Keto Blast website also offers expert advice on pre- and post-workout nutrition, recovery strategies, and how to stay hydrated and energized during your workouts. With a holistic approach to fitness and wellness, Keto Blast can help you maximize your results and achieve a balanced and healthy lifestyle that complements your keto diet.
Overall, the Keto Blast website is a one-stop destination for all things keto, offering a wealth of resources, support, and inspiration to help you achieve your health and wellness goals. Whether you’re just starting out on your keto journey or are looking to take your results to the next level, Keto Blast has everything you need to succeed. With its user-friendly interface, expert guidance, and vibrant community, Keto Blast makes it easy and enjoyable to embrace the keto lifestyle and reap the many benefits it has to offer.
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As you navigate the Keto Blast website, you may have some questions about the features and offerings available. Below are some frequently asked questions to help you make the most of your keto experience with Keto Blast:
Q: Are the meal plans on Keto Blast customizable?
A: Yes, the meal plans on Keto Blast are customizable to your individual needs and preferences. You can choose from a variety of options and tailor your meal plan to meet your specific goals and dietary requirements.
Q: Is the community support on Keto Blast active and engaging?
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A: Yes, the community support on Keto Blast is active and engaging, with forums, group challenges, and virtual meetups to help you connect with other keto enthusiasts, share your progress, and stay motivated on your keto journey.
Q: How can I access the expert guidance on Keto Blast?
A: You can access the expert guidance on Keto Blast through personalized coaching sessions, informative articles, and webinars that cover all aspects of the keto diet, from the science behind ketosis to practical tips for meal planning and grocery shopping.
Q: Are the product reviews and recommendations on Keto Blast reliable?
A: Yes, the product reviews and recommendations on Keto Blast are reliable, with honest and unbiased assessments of a wide range of keto products to help you make informed decisions about what to buy and what to skip.
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A: Yes, the workout plans and fitness tips on Keto Blast are suitable for all fitness levels, with options for beginner-friendly workouts you can do at home to advanced gym routines that target specific muscle groups. Whether you’re a fitness newbie or a seasoned athlete, you’ll find plenty of resources to help you stay active and motivated on your fitness journey.
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