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On World Obesity day, let us demystify myths around obesity! Five decades ago/ Pre 1980’s era, Obesity, type 2 diabetes & other metabolic diseases were a rare phenomenon. Our grandparents never had obesity- & they never had these fad recommendations of high protein, low carb & more but they had one aspect of our biology which we miss out now- balanced & diverse gut microbiome. No brainer- the foods they ate were rich in fibre & polyphenols which were food for their microbiome. Their gut microbes synthesised these food substrates & converted them into short chain fatty acids which secreted GLP-1- the hormone required to regulate our metabolism, satiety & appetite. GLP-1 communicates with Pancreas to regulate blood sugar response & communicates with the brain to modulate our hunger responses. Besides, our gut microbiome can make it hard to lose weight by 1.Low Grade Chronic Inflammation : Synthesising foods, not compatible with our biology, into pro-inflammatory metabolites such as LPS, TMAO & more which when released into the blood stream triggers inflammatory responses. In other words, this leads to high fat storage & low fat export. 2.Gut-Brain Axis: Gut communicates with the brain via Vagus nerve & impact hunger responses by impacting production of ghrelin, leptin & other hunger hormones. 3.If gut microbiome is less diverse, not producing enough enzymes or have now butyrate producing bacteria, it could stimulate hunger However, corporatization of foods & fad diets such as high protein & quantified nutrition has changed the entire microbial ecosystem inside our body triggering a wave of chronic inflammation. One of the most important reasons for obesity is degradation of GLP-1 which is caused by multiple metabolic pathways including those impacted by gut & oral microbiome. However, GLP-1 drugs being marketed as the solution for metabolic issues, leaves a lot of questions unanswered as it does not address the root cause- gut microbial dysbiosis. Besides, it brings its share of side effects & collateral damage including gastrointestinal issues- diarrhoea, bloating, constipation & more, loss of healthy muscle mass loss, inflammation of pancreas & even high risk of pancreatic cancer. Today's video discusses the role of gut & oral microbiome in obesity & each of the pathways associated with degradation of GLP-1 as well as what could make GLP-1 drugs ineffective & harmful Citations below https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112002/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082693/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187364/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266401/ https://pubmed.ncbi.nlm.nih.gov/23892476/ https://pubmed.ncbi.nlm.nih.gov/22506074/ https://www.nature.com/articles/s41598-018-20549-0

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इस वीडियो में मैंने बिना क्रैश डायट पर जाये घर के साधारण खाने को संतुलित मात्रा में खाने से कैसे शरीर को बिना नुक़सान पहुँचाये वजन घटाया जा सकता है यह विस्तार से बताया है और height के अनुसार कितना weight होना चाहिये इसका chart दिया है। In this video I have explained the easiest method to lose weight using a natural and balanced diet. Ideal Height/Weight Chart - https://bit.ly/3EOixtH 0:00 Introduction / परिचय 0:35 Problems due to obesity & excess weight / मोटापे के हानिकारक प्रभाव 1:06 Dangers of rapid weight loss / जल्दी वजन घटाने से क्या हानि हो सकती है 3:05 Weight Loss Diet / वजन काम करने वाली खुराक या डाइट 3:54 Breakfast for weight loss / सुबह का नाश्ता वजन कम करने के लिए 5:00 Lunch for weight loss / दोपहर का खाना वजन कम करने के लिए 6:35 Dinner for weight loss / रात का खाना वजन कम करने के लिए 8:06 Cooking tips for weight loss / वजन काम करने की कुछ और टिप्स