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How do we control satiation? It is provided by a complex work of receptors in the gastrointestinal canal that feels it’s wall dilatation by the food masses and sends a signal to the brain to induce satiation and satiety. Intestinal endocrine L-cells are among the major parts of the gut-brain axis. These cells produce anorectic peptide hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) as a response to the food intake. This process is described in our short MoA medical animation video. GLP-1, when released into the bloodstream, affects pancreatic β-cells, which secrete insulin, a hormone that controls the glucose level; decreases gastric emptying; increases satiation. Furthermore, GI motility is reduced and food consumption decreased by PYY. L-cells also seems to have precise nutrient-perception receptors that is responsible for the direct detection of macronutrients. This mechanism takes place in pathways that control decreasing the appetite and raise energy outlay. The nutrient-perception mechanisms could be used as a basic principle for the discovery of medicines to manage obesity and metabolic disease. Read full article on our webpage http://bit.ly/2DZG6BT Follow us on Facebook https://www.facebook.com/Nanobot.Medical.Animation/ Follow us on LinkedIn https://www.linkedin.com/company/nanobotmodels-medical-animation-studio/ Follow us on Twitter https://twitter.com/Nanobot_Studio Follow us on Instagram https://www.instagram.com/nanobot_medical_animation/ #histology #satiation #gastroenterology #bowel #nanobotmedical #animationvideos #animationreel #patienteducation #digitalartgallery #digitalartdesign #medicalillustration #animationlife #nanotechnology #medschool #microbiology #biology #illustrator #animation #lcell #glp1 #pyy #digestion

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