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Beyond the Scales is a short podcast series hosted by Emily, and Fran, who are both Year 4 Medical Students studying in the UK. alongside Mr Lee Humphreys, a Consultant Bariatric Surgeon who practises in the UK. The aim of the podcast is to dispel common myths surrounding obesity, specifically amongst medical students and other healthcare professionals In this episode, we discuss the impact that ultra-processed foods have on our ability to control our weight. Please find the references for the discussion below; Semaglutide - https://bnf.nice.org.uk/drugs/semaglutide/#important-safety-information Orlistat - https://bnf.nice.org.uk/drugs/orlistat/ NICE guidelines for obesity management - https://www.nice.org.uk/guidance/cg189/resources/obesity-identification-assessment-and- management-pdf-35109821097925 GLP-1 and the brain - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280675/#:~:text=These%20studies%20ha ve%20also%20shown,energy%20homeostasis%20and%20autonomous%20functions. Examples of GLP-1 analogues - https://www.diabetes.org.uk/guide-to-diabetes/managing- your-diabetes/treating-your-diabetes/tablets-and-medication/incretin-mimetics Liraglutide weight loss - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358074/ Semaglutide weight loss - https://www.nejm.org/doi/10.1056/NEJMoa2032183 Tirzepatide weight loss - https://www.nejm.org/doi/10.1056/NEJMoa2206038 Summary of clinical trials for GLP-1 receptor agonists - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509428/ Semaglutide trial - https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 Patient preferences for GLP-1 receptor agonists- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483112/ FDA evaluation of reports of suicidal thoughts related to GLP-1 receptor agonists - https://www.fda.gov/drugs/drug-safety-and-availability/update-fdas-ongoing-evaluation- reports-suicidal-thoughts-or-actions-patients-taking-certain- type#:~:text=Similarly%2C%20our%20reviews%20of%20the,of%20suicidal%20thoughts%20 or%20actions. Bariatric Surgery and risk of suicide - https://pubmed.ncbi.nlm.nih.gov/30343409/ Bariatric Surgery and gallstones - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011673/#:~:text=The%20incidence%20o f%20gallstone%20formation,recommended%20to%20prevent%20gallstone%20formation Oral semaglutide phase 3 clinical trials - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01185-6/abstract GLP-1 receptor agonist shortage - https://www.bmj.com/content/384/bmj.q28#:~:text=The%20supply%20of%20glucagon%2 Dlike,demand%20and%20off%2Dlabel%20use. GLP-1 receptor agonist shortage information - https://www.diabetes.org.uk/guide-to- diabetes/managing-your-diabetes/treating-your-diabetes/tablets-and-medication/incretin- mimetics/shortage-FAQs Unintended and adverse consequences of GLP-1 receptor agonists - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10495825/ NICE guidelines Phentermine (discontinued) - https://www.nice.org.uk/guidance/discontinued/gid-tag439 New clinical trials looking at obesity medications - https://www.clinicaltrialsarena.com/features/obesity-trials-to-watch/?cf-view Weight regain after stopping semaglutide - https://pubmed.ncbi.nlm.nih.gov/35441470/ Devon 2023 Tier 3 weight management average waiting times - https://www.royaldevon.nhs.uk/media/ieibfrgr/foi-rdf1222-23-tier-3-tier-4-weight- management-services.pdf Weight loss medications and bariatric surgery - https://link.springer.com/article/10.1007/s13679-021-00425-1 This video is aimed for use as an educational video and should not be taken as medical advice. Any ideas raised within this video should be discussed with a healthcare professional before making any changes.

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What diet should be taken in liver cancer? Liver Cancer is the fatal complication in liver cirrhosis. It has main treatment options available, depending upon the stage of liver cancer. if this cancer is diagnosed in its early stage, then its cure is possible. This video describes importance of well-balanced diet in such patients, and to avoid unnecessary dietary restrictions.

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