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Eli Lilly’s weight loss drug reduced the risk of developing Type 2 diabetes by 94% in obese or overweight adults with pre-diabetes compared to a placebo, according to initial results from a long-term study. The late-stage trial on tirzepatide also found that patients experienced sustained weight loss over the roughly three-year treatment period. Tirzepatide is the active ingredient in the company’s highly popular weight loss injection Zepbound and diabetes drug Mounjaro.

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Semaglutide, a medication originally used to treat type 2 diabetes, has recently gained attention for its potential as a weight loss tool. In clinical trials, semaglutide has shown impressive results in helping individuals shed pounds and improve their overall health. But how exactly does semaglutide work for weight loss in practice? Let’s take a closer look at the mechanism behind this promising drug and how it can support your weight loss journey.

The Role of Semaglutide in Weight Loss

Semaglutide belongs to a class of medications called GLP-1 receptor agonists, which work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is naturally produced in the intestine in response to food intake and plays a crucial role in regulating blood sugar levels, insulin secretion, appetite, and food intake.

By activating the GLP-1 receptors in the brain, semaglutide helps to reduce hunger and increase feelings of fullness, leading to a decrease in food intake. This can result in a reduced calorie intake, which is essential for weight loss. Additionally, semaglutide may also slow down the emptying of the stomach, further prolonging feelings of satiety.

Moreover, semaglutide has been shown to improve insulin sensitivity and reduce inflammation in the body, both of which are beneficial for weight management and overall metabolic health. By addressing these underlying factors, semaglutide can help individuals achieve sustainable weight loss and improve their overall well-being.

How Semaglutide is Administered

Semaglutide for weight loss is typically administered as a subcutaneous injection once a week. The starting dose is low to minimize side effects and is gradually increased over time to a maintenance dose. It is important to follow your healthcare provider’s instructions carefully and not to adjust the dosage on your own.

It is also essential to combine semaglutide treatment with healthy lifestyle modifications, such as a balanced diet and regular exercise, to achieve the best results. Semaglutide is not a magic bullet for weight loss but rather a tool to support your efforts in making sustainable lifestyle changes.

Some common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation, especially during the initial stages of treatment. These side effects usually subside as your body adjusts to the medication. However, if you experience severe or persistent side effects, it is crucial to consult your healthcare provider.

Considerations Before Starting Semaglutide

Before starting semaglutide for weight loss, it is essential to discuss with your healthcare provider about your medical history, current medications, and any underlying health conditions. Semaglutide may not be suitable for individuals with a history of pancreatitis, thyroid tumors, or certain gastrointestinal disorders.

Additionally, women who are pregnant or breastfeeding should not use semaglutide, as its safety in these populations has not been established. It is crucial to use effective contraception while on semaglutide treatment to prevent unintended pregnancy.

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If you have any concerns or questions about semaglutide or its potential benefits and risks, do not hesitate to talk to your healthcare provider. They can provide personalized advice and guidance based on your individual health needs and help you decide if semaglutide is the right option for you.

Monitoring and Long-Term Success with Semaglutide

Regular monitoring of your progress and overall health is essential when using semaglutide for weight loss. Your healthcare provider may recommend periodic blood tests, weight measurements, and check-ins to assess your response to the medication and make any necessary adjustments.

It is also crucial to have realistic expectations and understand that weight loss with semaglutide may vary from person and can take time. Consistency with your treatment plan and dedication to healthy habits are key to achieving long-term success with semaglutide and maintaining your weight loss in the future.

Remember that weight loss is a journey that requires patience, commitment, and support. With the help of semaglutide and a healthcare team, you can take positive steps towards a healthier weight achieving your weight loss goals and improving your overall well-being.

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(10 Jan 2006) 1. Wide of exteriors of surgery ward at Polyclinic Hospital Umberto I 2. Exterior of balloon procedure room 3. Room with nurses preparing for balloon inserting procedure 4. Balloon procedure kit 5. Pan down from inflated balloon to a flat one 6. Close up of medical information card 7. Inflated balloon 8. Wide of a surgery room 9. Chief surgeon Nicola Basso preparing for surgery 10. Close up of medical machine 11. SOUNDBITE (Italian) Nicola Basso, Chief surgeon at Polyclinic Hospital Umberto I and Director of balloon procedures: ''It's an endoscopic procedure, which means it doesn't need a general anaesthesia. with an instrument that's usually used to practice endoscopy, a 1/2 litre volume balloon is inserted and is inflated inside the stomach. It occupies a part of the stomach and it slows down stomach emptying. All this produces a lack of appetite, a satiated feeling, all of which makes easier for the patient to lose weight.'' 12. Balloon procedure kit 13. Procedure room with doctors and a patient ready to be operated 14. SOUNDBITE (Italian) Vittorio Campati, Patient ''I'm 140 kilos. With the intragastric balloon I hope to lose weight.'' 15. Doctor preparing drip bottle 16. Sedated patient on operation table 17. Flat balloon is inserted through the patient's mouth 18. Images of the patient's stomach on screen as doctors carry out procedure 19. Doctor's hands inflating balloon, which is inside stomach 20. Endoscopy camera shot of stomach 21. Endoscopy camera inserted through the patient's mouth 22. Various of doctors looking to the endoscopy images of balloon inflating 23. Patient awaking after 10 minute operation 24. Simona Spalliera, patient, walking down hall to show her weight loss 25. SOUNDBITE (Italian) Simona Spalliera, 33 years old patient: ''I've kept the balloon for six months - six months and a half. I weighed 100 hundred kilos. Naturally I stopped measuring my weight because I was so demoralised that I didn't want to know it anymore. I have now lost around 30 kilos.'' 26. Wide of exteriors of Polyclinic Hospital Umberto I SUGGESTED LEAD-IN: After holidays full of too much food and plenty of drink - many people include "losing weight" in the list of new year's resolutions. In Italy, a new medical procedure is making this goal much easier for some to obtain. A balloon is inserted into the stomach and inflated so that patients feel full and eat less. VOICE-OVER: The New Year often brings an appetite for the latest diet fads and exercise regimes in the hopes of shedding a few extra pounds. In Italy, achieving that weight loss could be a bit easier with new "anti-obesity" balloons. These balloons are inserted in the stomach in a simple procedure to give the feeling of being full. And if you feel full, you're likely to eat less which will lead to weight loss. Italian surgeon, Nicola Basso, has been testing the procedure in Rome at the Polyclinic Hospital Umberto I since 1998. He says the procedure is only minimally invasive. SOUNDBITE (Italian) ''It's an endoscopic procedure, which means it doesn't need a general anaesthesia. With an instrument that's usually used to practice endoscopy, a 1/2 litre volume balloon is inserted and is inflated inside the stomach. It occupies a part of the stomach and it slows down stomach emptying. All this produces a lack of appetite, a satiated feeling, all of which makes easier for the patient to lose weight.'' SUPER CAPTION: Nicola Basso, chief surgeon at Polyclinic Hospital Umberto I The balloon contains blue coloured liquid, in order to detect possible leaks. Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: https://twitter.com/AP_Archive Facebook: https://www.facebook.com/APArchives Instagram: https://www.instagram.com/APNews/ You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/4fa92418b57e86a220a99fcb19b90de1

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