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On World Obesity day, let us demystify myths around obesity! Five decades ago/ Pre 1980โs era, Obesity, type 2 diabetes & other metabolic diseases were a rare phenomenon. Our grandparents never had obesity- & they never had these fad recommendations of high protein, low carb & more but they had one aspect of our biology which we miss out now- balanced & diverse gut microbiome. No brainer- the foods they ate were rich in fibre & polyphenols which were food for their microbiome. Their gut microbes synthesised these food substrates & converted them into short chain fatty acids which secreted GLP-1- the hormone required to regulate our metabolism, satiety & appetite. GLP-1 communicates with Pancreas to regulate blood sugar response & communicates with the brain to modulate our hunger responses. Besides, our gut microbiome can make it hard to lose weight by 1.Low Grade Chronic Inflammation : Synthesising foods, not compatible with our biology, into pro-inflammatory metabolites such as LPS, TMAO & more which when released into the blood stream triggers inflammatory responses. In other words, this leads to high fat storage & low fat export. 2.Gut-Brain Axis: Gut communicates with the brain via Vagus nerve & impact hunger responses by impacting production of ghrelin, leptin & other hunger hormones. 3.If gut microbiome is less diverse, not producing enough enzymes or have now butyrate producing bacteria, it could stimulate hunger However, corporatization of foods & fad diets such as high protein & quantified nutrition has changed the entire microbial ecosystem inside our body triggering a wave of chronic inflammation. One of the most important reasons for obesity is degradation of GLP-1 which is caused by multiple metabolic pathways including those impacted by gut & oral microbiome. However, GLP-1 drugs being marketed as the solution for metabolic issues, leaves a lot of questions unanswered as it does not address the root cause- gut microbial dysbiosis. Besides, it brings its share of side effects & collateral damage including gastrointestinal issues- diarrhoea, bloating, constipation & more, loss of healthy muscle mass loss, inflammation of pancreas & even high risk of pancreatic cancer. Today's video discusses the role of gut & oral microbiome in obesity & each of the pathways associated with degradation of GLP-1 as well as what could make GLP-1 drugs ineffective & harmful Citations below https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112002/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082693/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187364/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266401/ https://pubmed.ncbi.nlm.nih.gov/23892476/ https://pubmed.ncbi.nlm.nih.gov/22506074/ https://www.nature.com/articles/s41598-018-20549-0
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In this episode, Dr. Tyna is joined by Dave Knapp to explore why compounded GLP-1 medications like semaglutide and tirzepatide have become essential for millions of Americans. As demand skyrocketed and commercial supply struggled to keep up, compounding pharmacies stepped in to bridge the gap โ but not without regulatory challenges. Together, they break down the complex landscape of 503A and 503B pharmacy designations, the FDAโs shifting stance on shortages, and how policy decisions are impacting access for patients who truly need these medications. This conversation dives into the history of pharmaceutical compounding, the real-world implications of drug shortages, and why preserving access to affordable compounded GLP-1s is more important now than ever. _____________________________________________________________________________________________ ๐๐ง๐ฌ๐ญ๐๐ ๐ซ๐๐ฆ - https://www.instagram.com/drtyna/ ๐๐๐๐ฌ๐ข๐ญ๐ - https://www.drtyna.com/ ๐๐ญ๐จ๐ซ๐ - https://store.drtyna.com/ ๐๐จ๐ฎ๐ซ๐ฌ๐๐ฌ - https://www.drtyna.com/store ๐๐๐ญ๐๐๐จ๐ฅ๐ข๐ ๐๐๐ฏ๐๐ฆ๐ฉ ๐๐จ๐จ๐ฅ๐ค๐ข๐ญ - https://bit.ly/drtynametabolicrevamp ๐ ๐๐๐ ๐๐ฎ๐ข๐๐ - Assess Your Metabolic Health - https://www.drtyna.com/metabolism GLP1's Uncovered FREE 4 Part Video Series https://www.drtyna.com/ozempicuncovered ๐บ๐๐๐๐๐๐๐๐ ๐๐ ๐ป๐๐ ๐ซ๐. ๐ป๐๐๐ ๐บ๐๐๐: ๐Apple Podcasts: https://apple.co/4bm3R3m ๐ตSpotify: https://spoti.fi/3OtOps7 ๐๏ธSubstack: https://drtyna.substack.com/ _____________________________________________________________________________________________ ๐๐๐ฆ๐๐๐๐๐ ๐๐ฅ: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
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Youโre Not Losing Fat in the Areas You Want Many people struggle with stubborn fat in specific areas like the belly, thighs, or arms even when they're dieting and exercising. The main reason? Spot reduction is a myth. Your body doesnโt burn fat from specific spots just because you want it to. Instead, fat loss happens overall, and genetics, hormones, and body type determine where fat is lost first. Hereโs why certain areas hold on to fat longer: 1. Genetics: Your body has a predetermined pattern of fat storage and loss. Some people lose belly fat first; others might lose it last. 2. Hormones: Hormonal imbalances (like cortisol from stress or insulin resistance) can cause fat to accumulate in certain areas. 3. Lack of muscle: Areas with less muscle tone may appear softer or more stubborn, even as you lose fat. 4. Inconsistent habits: Poor sleep, high stress, or inconsistent nutrition/exercise routines can stall fat loss. What to do instead: Focus on overall fat loss through consistent exercise (especially strength training and cardio). Eat in a slight calorie deficit with a focus on whole foods. Manage stress and sleep to keep hormones in balance. Be patient stubborn fat is often the last to go.
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๐ค Did you know that Metformin & other diabetes medications can deplete your body of three crucial nutrients? ๐ Vitamin B12 is essential for cellular energy, and without it, your energy levels can drop. ๐ Folate, or folic acid, is key for DNA synthesis and cell repair, so a lack of it hinders healing and proper cell function. ๐ Coenzyme Q10, or CoQ10, is vital for muscle strength and energy, and its depletion can cause muscle weakness, pain, and fatigue. I am so passionate about this topic because rates of insulin resistance, pre-diabetes, and diabetes have absolutely skyrocketed in our country โ and so have the perscriptions for these medications. But the reality is there are so many natural, holistic techniques you can use to battle sugar-related disease. If you want to learn about my top tactics to battle insulin resistance at a LIVE virtual, comment HEAL to join me and Dr. Will Cole on August 12th for our free event A Day to Heal. You don't have to stay dependent on medication. Share this with someone you know who is struggling with one of these diagnoses. #Nutrient #Vitamin #Diabetes #HealthJourney #TakeControl #drjoshaxe -------------------- ABOUT DR. JOSH AXE Dr. Josh Axe, DC, DNM, CNS, is a doctor of chiropractic, certified doctor of natural medicine, clinical nutritionist, leadership expert and highly successful entrepreneur, with a passion to help people eat healthy and live a healthy lifestyle. He earned his doctorate from Palmer College and his Master of Science in Organizational Leadership from Johns Hopkins University. Dr. Axe is the cofounder and CVO of Ancient Nutrition, founder of DrAxe.com, and founder of The Health Institute. His businesses have ranked on the Inc. 500 fastest growing companies. He is the bestselling author of Think This Not That, Eat Dirt, Keto Diet, and Ancient Remedies. He regularly teaches lectures and trains entrepreneurs on leadership, mindset, and self- development. Josh is married to his wife, Chelsea, and they have two daughters. They live between Nashville, TN and Dorado, PR and enjoy cooking, staying active swimming and cycling, and prioritize time for their faith and family. -------------------- โ CONNECT WITH DR. JOSH AXE Like on Facebook โ facebook.com/drjoshaxe/ Follow on Instagram โ instagram.com/drjoshaxe/ Follow on Twitter โ twitter.com/drjoshaxe/ Follow on TikTok โ tiktok.com/@thedrjoshaxeshow/ Website โ https://joshaxe.com/ -------------------- DISCLAIMER This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
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