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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].

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I decided to make a video about some supposed Mark Harmon CBD gummies, keto gummies, or weight loss diet pills, which is all a scam. Harmon has nothing to do with any of this. Mark Harmon never, ever, endorsed apple cider vinegar (ACV) keto gummies, CBD gummies, or diet pills or weight loss supplements. This weight loss scam claimed that Mark Harmon endorsed various keto gummies, CBD gummies, or diet pills products, which was false. This was all a big fake celebrity endorsement scam. She and other celebrities who appear in these scams have nothing to do with these keto or CBD gummies products. Stay far away from all of this nonsense. Let’s make one thing clear. Ree Drummond aka “The Pioneer Woman” and Oprah Winfrey never endorsed any keto or CBD gummies products of any kind, ever. These celebrities have nothing to do with these products. On Facebook, I’ve found no shortage of scam pages that claimed celebrities like Mark Harmon endorsed CBD and keto gummies or diet pills or supplements, and many of these pages were recently created. None of this was legitimate. Most of the pages had zero followers, which was obviously a big red flag that something was off. The pages all included links that appeared to perhaps be designed for affiliate marketing. It’s also possible that the scammers had end goals that I wasn’t aware of. If you’ve fallen victim to a CBD or keto gummies scam or fake “review” or bought an Amazon listing that was scammy, please let me know in the comments below. Also, feel free to ask me questions about this scam or any scam. My comments are open. Thank you for watching and feel free to hit “Like” (thumbs up) so that Google knows my video is trustworthy, and so other people, including potential victims of scams, might see what I’ve laid out here. Image Credit: Wikimedia Commons

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In this video i will tell you about how to control blood pressure naturally. If you have high blood pressure, you may wonder if medication is necessary to bring the numbers down. But lifestyle plays a vital role in treating high blood pressure. Controlling blood pressure with a healthy lifestyle might prevent, delay or reduce the need for medication. Here are some tips in this video, watch the video. Your Queries :- high blood pressure blood pressure how to lower blood pressure how to lower blood pressure naturally high blood pressure treatment how to lower high blood pressure how to lower blood pressure without medicine blood pressure control high blood pressure remedies how to reduce high blood pressure naturally lower blood pressure without medication how to lower blood pressure immediately how to lower blood pressure without medication #healthtips #bloodpressure #Naturalcontrol #drhassanrao Aslam u Alaikum Viewers :- Welcome to "Dr Hassan Rao" youtube channel. Here i share educational & informative videos on all important medical topics, Medicines, diseases, foods, health and wellness of human being.This channel is to promote health status of our kids and educate parents about basic nutrition, parenting and about different diseases. We also try to breaks different MYTHS in society related to child health. Moreover i also share my personal and informative Vlogs on my channel. My name is "Dr Muhammad Hassan Rao " and i'm a Pharmacist doctor (Pharm-D), i also have DHMS degree (Doctor of homeopathy).I have about 10years working experience. You can also follow and contact me at... Facebook... https://www.facebook.com/muhammadhassan.rana.79?mibextid=ZbWKwL Instagram... https://instagram.com/hassanrao241?igshid=MzNlNGNkZWQ4Mg== Tiktok......... https://www.tiktok.com/@drhassanrao1201?_t=8dtRpbpW9TE&_r=1 Thanks for visit and watching my channel, if u like my videos plz like, share and subscribe my channel for more heathy and informative videos.

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Obesity is a prevalent health issue affecting millions of people worldwide, leading to various complications such as diabetes, heart disease, and stroke. In recent years, there has been a growing interest in semaglutide, a medication initially approved for the treatment of type 2 diabetes, for its potential in weight loss. Semaglutide works by mimicking a hormone that regulates blood sugar levels and may also help suppress appetite, leading to reduced food intake and weight loss.

What is Semaglutide?

Semaglutide is a medication belonging to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs work by stimulating insulin secretion in response to high blood sugar levels, reducing glucagon production, slowing down gastric emptying, and promoting feelings of fullness. Semaglutide is typically administered via subcutaneous injection once weekly and has been shown to be effective in lowering blood sugar levels in patients with type 2 diabetes.

Researchers have also been investigating the potential of semaglutide for weight loss in individuals with obesity, as studies have shown promising results in terms of reducing body weight and improving metabolic parameters. This has led to the approval of semaglutide for chronic weight management in overweight or obese individuals with a body mass index (BMI) of 30 kg/m² or higher, or in individuals with a BMI of 27 kg/m² or higher with at least one weight-related comorbidity, such as hypertension or dyslipidemia.

The highest dose of semaglutide approved for weight loss is 2.4 mg once weekly. This dose has been shown to be more effective in promoting weight loss compared to lower doses, with clinical trials demonstrating an average weight loss of around 15-20% of total body weight over a 68-week period. It is important to note that semaglutide should be used in conjunction with a reduced-calorie diet and increased physical activity for optimal results.

Potential Side Effects of Semaglutide

As with any medication, semaglutide may cause side effects in some individuals. Common side effects of semaglutide include nausea, vomiting, diarrhea, abdominal pain, and constipation. These side effects are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication. In some cases, semaglutide may also cause more serious side effects such as pancreatitis, gallbladder disease, and kidney problems.

It is essential to consult with a healthcare provider before starting treatment with semaglutide, especially if you have a history of pancreatitis, thyroid tumors, or other medical conditions. Your healthcare provider will assess your overall health status and determine if semaglutide is a safe and appropriate option for you. It is crucial to follow your healthcare provider’s instructions regarding the administration of semaglutide and to report any side effects or concerns promptly.

In conclusion, semaglutide is a promising medication for weight loss in individuals with obesity, offering a new treatment option for those struggling to achieve and maintain a healthy weight. The highest dose of semaglutide approved for weight loss is 2.4 mg once weekly, and it has been shown to be effective in promoting significant weight loss when combined with lifestyle modifications. If you are considering semaglutide for weight loss, speak to your healthcare provider to discuss the potential benefits and risks of this medication.