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Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.com In this journal club episode, Victoria Field is joined by Dr. Angela Poff and Dr. Dominic D’Agostino to dive into two groundbreaking studies shaping our understanding of metabolism and its role in health and disease. The team explores the nuances of a recent randomized controlled trial on ketogenic diets, free sugar restriction, and their effects on glucose tolerance, lipid metabolism, and the gut microbiome. Then, they tackle a cutting-edge study uncovering the molecular mechanisms of ketogenic diets in reshaping cancer metabolism through lysine beta-hydroxybutylaration. From the clinical implications of these findings to the potential of ketone supplementation, this episode is packed with insights for researchers, clinicians, and health enthusiasts. Don’t miss the opportunity to learn how these discoveries could shape the future of precision medicine. 🔍 Study 1: Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00381-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379124003811%3Fshowall%3Dtrue 🔍 Study 2: Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation: https://www.nature.com/articles/s42255-024-01093-w Referenced study related to cardiometabolic health - Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial: https://www.jacc.org/doi/10.1016/j.jacadv.2024.101109 Special thanks to the sponsors of this episode: Genova Connect: Receive 15% off any of their tests with code metaboliclink here: https://www.gdx.net/themetaboliclink Fatty15: Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK here: https://partners.fatty15.com/METABOLICLINK Maui Nui: Get 15% off your first order of Maui Nui with the code METABOLICLINK by visiting this link: https://mauinuivenison.com/metaboliclink In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. Listen to this episode on your favorite podcast player, and if you like it, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

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