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The press briefing delves into the key trends and figures of medicines recommended for approval in 2024. EMA's experts discuss new treatments addressing unmet patient needs, areas of significant development, and the agency's focus for the future. It also highlights developments and recent progress in neurology and psychiatry. Finally, questions from the press are addressed concerning obesity medicines, regulatory harmonisations, and future drug candidates. *Find the chapters here:* 0:00 Introduction 2:27 Overview of 2024 Medicine Approvals 2:48 Key Figures 3:30 New Active Substances 3:59 Orphan Designations 4:19 Therapeutic Areas 4:53 Highlighted Medicines 6:11 Infectious Diseases 11:27 Biosimilars 12:56 Neurology and Psychiatry Focus 13:17 Impact of Brain Disorders 14:16 Challenges in Development 15:20 2024 Achievements 16:55 Horizon Scanning 17:24 Psychedelics Workshop 19:09 Questions and Answers 19:38 Obesity Medicine and Muscle Loss (Sarcopenia) 24:25 Regulatory Harmonisations 28:36 Future Medicine Candidates 31:11 GLP-1 Receptor Agonists and Nutrition 31:44 New HTA Regulation 34:36 Closing Remarks #EMA #EuropeanMedicinesAgency #EuropeanUnion

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沖縄の美容医療なら クララ美容皮膚科 那覇院🏥 院長の仲田 力次(なかだ りきじ)です👨‍⚕️ 日本では本来、リベルサスやマンジャロは糖尿病患者の方に服用いただくものになっております。 くれぐれも健康な方のご利用は、かかりつけ医にご相談の上でご判断をお願いします。 【目次】 0:00 はじめに 0:32 医療ダイエットについて 1:51 なぜ体重が減るのか? 3:56 GLP-1薬の本来の用途と海外の使用方法 4:49 リベルサスとマンジャロの違い 6:30 最後に こちらの動画が良いと思いましたら、 チャンネル登録と高評価をぜひよろしくお願いいたします! ■Youtubeチャンネル登録はこちら https://www.youtube.com/@rikijinakada ■Instagram https://www.instagram.com/clara_okinawa/ ■TikTok https://www.tiktok.com/@rikijinakada ■公式HP(クララ美容皮膚科 那覇院) https://clarabeautyclinic.jp/nahain/ #リベルサス #マンジャロ #GLP-1

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Note: This is not a follow-along workout video, but a timer video for those who need it during their own workout session. Due to the strong demand for the workout timer that I use in all my workout videos. This is probably the best way for me to share the timer, or you can download this timer App here: https://bit.ly/trainwithjordanapp Enjoy! ▷Connect with Me Instagram: https://www.instagram.com/jordanyeohfitness Facebook: http://facebook.com/jordanyeohfitness Training App: https://bit.ly/trainwithjordanap #fitness #workout #weightloss

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Click Here to Subscribe: http://Bit.ly/ThomasVid Website: http://ThomasDeLauer.com Get the Apparel I Wear at http://www.Hylete.com Does a Sauna Benefit You or Improve Fat Loss? - Thomas DeLauer I'm about to totally wow you with the science of how sitting in a sauna for just a short amount of time after a workout or in general can totally shift the way that your body metabolizes energy and shift the way that your body built muscle and burns fat. When we're looking at how a sauna affects the body, we're looking at something known as hyperthermic conditioning. Hyperthermic conditioning is just like the name implies. We're conditioning ourselves to be a little bit more exposed to a higher temperature. With hyperthermic conditioning, we're acclimating our bodies to heat independent of aerobic activity. Normally if you go out for a run or you do some kind of aerobic exercise, your core body temperature is going to go up, simply because you're moving. With hyperthermic conditioning, we're trying to elicit the same response, but without the actual activity. We're just trying to get the core body temperature up and still trying to get the same benefits, and now, the science is showing the benefits are there. Basically what we're doing is we're trying to build a generalized tolerance to physiological stress by adapting to heat. Just like anything, we have an adaptation process that occurs, and when we expose ourselves to a lot of heat, we do have this adaptation that occurs at a cellular level and different metabolic levels. Now the biggest one that we probably know of already is the increase in blood flow and plasma volume. This one kinda goes without saying. When you have more heat, your blood vessels dilate, you get more blood flow, yeah, that's all fine and dandy, but there's a lot of really cool stuff coming out in the way of what are called heat shock proteins. Now the studies that I'm gonna reference in this video, and believe me, there's quite a few of them, are going to really be centered around heat shock proteins and what these heat shock proteins do for not only your recovery, but your overall metabolism. A heat shock protein is a highly conserved protein that sits inside of a cell. Every single organism has them and every single cell has heat shock proteins. They're proteins that sit in a reserve mode, waiting to get acted upon by high stress, for instance, high heat. That's why they're called heat shock proteins. When our cells are exposed to heat shock, these proteins are released, and they protect what are called the folding and unfolding of these different proteins inside of a cell. Inside of a cell, when you build a cell, you have proteins that fold on top of each other. Now sometimes they unfold, sometimes they fold, so these heat shock proteins stabilize them. They hold them in place so that they have a little bit more time to recover when exposed to extreme conditions like high heat. References 1) Li Z and Srivastava P. (n.d.). Heat-shock proteins. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18432918 2) Heat shock proteins - an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/heat-shock-proteins 3) Heat Stress and Cardiovascular, Hormonal, and Heat Shock Proteins in Humans. (2012, March). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418130/ 4) Selsby JT , et al. (n.d.). Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17110516 5) Wei Q , et al. (n.d.). Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21511696 6) Costa RJ , et al. (n.d.). Heat acclimation responses of an ultra-endurance running group preparing for hot desert-based competition. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24444197 7) Scoon GS , et al. (n.d.). Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16877041 8) Kukkonen-Harjula K , et al. (n.d.). Haemodynamic and hormonal responses to heat exposure in a Finnish sauna bath. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2759081 9) Laatikainen T , et al. (n.d.). Response of plasma endorphins, prolactin and catecholamines in women to intense heat in a sauna. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2830109 10) Running enhances neurogenesis, learning, and long-term potentiation in mice. (9, November). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23964/

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