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The Future of Obesity Therapy and the Development of GLP-1 Drugs Today, we have Tirzepatide (brand names: Zepbound, Mounjaro) and Semaglutide (Ozempic, Wegovy). Who’s next? When will the next weight loss injection — or finally a weight loss pill — be released in the coming years? Let’s take a look at the overview table together. From left to right: This table provides an overview of upcoming and future pharmaceutical drugs for weight loss or metabolic disorders, categorized by year, company, drug name, and pharmaceutical formulation (oral or injection). Orforglipron (Eli Lilly) – Oral GLP‑1RA small molecule taken once daily Clinical results: Phase III ACHIEVE‑1 (type 2 diabetes): Lowered A1C by 1.3–1.6 pp and body weight by ~7.9% (~16 lb) at 40 weeks vs ~1.6% weight loss for placebo businessinsider.com+5 Oral Semaglutide – Novo Nordisk (“Rybelsus”) Novo Nordisk has submitted an application to the U.S. Food and Drug Administration (FDA) for oral semaglutide (a 25 mg once‑daily formulation of Wegovy) aimed at chronic weight management: ,based on encouraging Phase III OASIS‑4 data 25md oral Semaglutide is showing around 13.6 % mean weight loss at 64 weeks In May 2025, the FDA officially accepted the NDA and will decide in Q4 2025 Retatrutide (LY‑3437943) – Eli Lilly Mechanism: A triple agonist targeting GLP‑1, GIP, and glucagon receptors prnewswire.com+15 hase 2 (48 weeks): 8 mg dose → –22.8% body weight reduction 12 mg dose → –24.2% body weight reduction (~58 lb) Also reduced liver fat in patients with metabolic steatotic liver disease VK2735 – Viking Therapeutics (injectable + oral) Mechanism: Dual GLP‑1 and GIP receptor agonist (similar to tirzepatide) en.wikipedia.org. Formulations: Subcutaneous (weekly): Phase 2 data showed up to 14.7% weight loss in 13 weeks, with 88% of subjects achieving ≥10% weight loss pharmexec.com. Oral (daily): Phase 1 MAD study: Up to 8.2% weight loss over 28 day

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