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Hello my Quora friends, We are starting the everyday fitness challenge from today. I am neither a fitness model nor a professional video maker, I have started this initiative just because it will help me too to get in shape. My aim here is not to obsess over losing weight but more about staying committed to routine by doing as little as one exercise. I will be very happy if you find this helpful. Thank you. All you need to do is * Do this one exercise till you get tired * You can also use ankle weights * Do 3 minutes of warm up before doing the main work out * Warm up includes - jumping jacks, lifting legs alternatively, jogging on spot

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A Lancet study predicts that over 45 crore Indians could be overweight or obese by 2030. However, the situation could improve with the launch of the GLP-1 anti-obesity drugs in India. Dr Sonali Kagne of Sir HN Reliance Foundation Hospital & Dr Ambrish Mithal, Group Chairman & Head of Oncology & Diabetes at Max Healthcare join in to discuss the potential side effects, treatment regimes and effectiveness of these drugs. #medicinebox #obesity #drugs #india #weightlossdrugs #GLP-1 #antiobesitydrugs #cnbctv18 🔴CNBC TV18 LIVE TV: https://youtube.com/live/P857H4ej-MQ SUBSCRIBE to our Channel: https://bit.ly/3nvEcxf --------------------------------------------------------------------------------------------------------------------- 👑 Check Out Top CNBC TV18 Playlist Videos: 🔹Young Turks Reloaded with Shereen Bhan: https://www.youtube.com/playlist?list=PLjq9mRS1PfGAeBW0FxoO8D2cbKx8YPKAZ 🔹 World News: https://www.youtube.com/playlist?list=PLjq9mRS1PfGDHHT6b309VWbeVIxjc73r0 🔹CNBC TV18 Classic Interviews: https://www.youtube.com/playlist?list=PLjq9mRS1PfGDmfXVg7XEQngsCY9RoS-fv 🔹CNBC TV18 Digital: https://www.youtube.com/playlist?list=PLjq9mRS1PfGDCcaVZ_82M9vhLo9lGJYzo 🔹CNBC TV18 Weekend Special: https://www.youtube.com/playlist?list=PLjq9mRS1PfGBHEa5NnoKuUsX5GwxEGuri 🔹CNBC TV18 Next-Gen: https://www.youtube.com/playlist?list=PLjq9mRS1PfGA6roe9q3J9fq_gBIDjX2w7 🔹Overdrive Show: https://www.youtube.com/playlist?list=PLjq9mRS1PfGCnSVjfbWfNCJLrv-CqfGmH 🔹CNBC TV18 Newsreels: https://www.youtube.com/playlist?list=PLjq9mRS1PfGCmABWWQRX4NqGLCtScwqex 🔹Startup Streets: https://www.youtube.com/playlist?list=PLjq9mRS1PfGD3CzrtMr_VJRbIly6sfyFI ------------------------------------------------------------------------------------ You can also connect with CNBC-TV18 News Online Catch the latest news: https://bit.ly/2YbpXBM Follow CNBC-TV18 round the clock: https://www.cnbctv18.com/live-tv/ Stay updated with all the market action in real time: https://www.cnbctv18.com/market-live/ You can also stay updated with all the latest news on-the-go with CNBC-TV18 Minis: https://www.cnbctv18.com/minis/ Like us on Facebook: https://www.facebook.com/cnbctv18india/ Follow us on Twitter: https://twitter.com/CNBCTV18News Follow us on Instagram: https://www.instagram.com/cnbctv18india/ Catch us on: Linkedin: https://in.linkedin.com/company/cnbc-tv18 n18oc_business About CNBC-TV18: India's leading business news channel, CNBC-TV18 offers the most comprehensive coverage of businesses, the economy and the financial markets. Catch all your favourite shows, exclusive videos, big-ticket interviews and more here.

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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt

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