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In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity." We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways. First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose. Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings. #HubermanLab #Science Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman Levels: https://levels.link/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Dr. Peter Attia Website: https://peterattiamd.com Outlive: The Science & Art of Longevity: https://peterattiamd.com/outlive The Peter Attia Drive Podcast: https://peterattiamd.com/podcast Newsletter: https://peterattiamd.com/newsletter X (formerly Twitter): https://twitter.com/PeterAttiaMD Instagram: https://www.instagram.com/peterattiamd YouTube: https://www.youtube.com/c/PeterAttiaMD Facebook: https://www.facebook.com/peterattiamd Articles Reassessing the evidence of a survival advantage in Type 2 diabetes treated with metformin compared with controls without diabetes: a retrospective cohort study: https://bit.ly/3EypTAJ The Hallmarks of Aging: https://bit.ly/3ZeqnFI Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls: https://bit.ly/3Lespjp A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers: https://bit.ly/3LiAaEX Other Resources TAME (Targeting Aging with Metformin) Trial: https://bit.ly/3P7eMDI Interventions Testing Program (ITP): https://bit.ly/3EDtmOg Slow-Carb Diet (Tim Ferris): https://bit.ly/462q6YD Dr. Alia Crum: Science of Mindsets for Health & Performance (Huberman Lab episode): https://bit.ly/3PdbKhd Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping (Huberman Lab episode): https://bit.ly/3PkGopc Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects (Huberman Lab episode): https://bit.ly/3Pg7jT3 Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction (Dead salmon study): https://bit.ly/3PvJvf9 Timestamps 00:00:00 Dr. Peter Attia, Journal Club 00:03:27 Sponsors: Helix Sleep & Levels 00:06:11 Dreams 00:12:36 Article #1, Metformin, Mitochondria, Blood Glucose 00:19:47 Type 2 Diabetes & Causes, Insulin Resistance 00:25:30 Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study 00:36:19 Sponsor: AG1 00:37:15 TAME Trial; Demographics, Twin Cohort 00:44:27 Metformin & Mortality Rate 00:51:28 Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power 01:01:17 Sponsor: InsideTracker 01:02:23 Hazard Ratios, Censoring 01:09:00 Metformin Advantage?, Variables, Interventions Testing Program 01:16:02 Berberine, Acarbose, SGLT2 Inhibitors 01:23:48 Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers 01:32:22 Tool: Reading Journal Articles, 4 Questions, Supplemental Information 01:38:10 Article #2, Belief Effects vs. Placebo Effect 01:45:22 Nicotine Effects 01:51:07 Nicotine Doses & Belief Effects, fMRI Scan 02:00:07 Biological Effects, Dose-Dependent Response & Belief Effects 02:05:14 Biology & Beliefs, Significance, Dopamine Response, Non-Smokers 02:10:57 Dose-Dependence & Beliefs, Side Effects, Nocebo Effect 02:19:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer

Coconut Oil Fatblaster Ketogenic Diet

#Berberine #BerberineBenefits #BerberineSupplement #NaturalBloodSugarSupport #BerberineForDiabetes #BloodSugarBalance #NaturalInsulinSupport #GlucoseControl #CholesterolSupport #GutHealthNaturally #FunctionalMedicine #MetabolicHealth #InflammationSupport #BiohackingSupplements #NaturalRemedies #HerbalMedicine #Adaptogens #Antioxidants #HolisticHealing #AncientWisdomModernScience #HealthHack #SupplementsThatWork #HealthTipsDaily #WellnessThread #SupplementStack #NaturalHealing #WellnessTools #SmartSupplements #HealthyLiving benefits of berberine: बर्बरीन बोले तो अच्छी सेहत की गारंटी बेर्बेरिन क्या है? बेर्बेरिन एक शक्तिशाली बायोएक्टिव यौगिक है जो कई पौधों से प्राप्त होता है, जैसे कि Berberis vulgaris (दारुहल्दी/बरबेरी)। इसका उपयोग सदियों से आयुर्वेद और चीनी चिकित्सा पद्धति में होता आया है — और अब आधुनिक विज्ञान भी इसके कई फायदों को मान्यता दे रहा है। 🔬 1. ब्लड शुगर को नियंत्रित करता है (Metformin के समान प्रभाव) AMPK (AMP-activated protein kinase) को सक्रिय करता है, जो शरीर का “मेटाबोलिक मास्टर स्विच” है। उपवास ब्लड ग्लूकोज़, HbA1c और भोजन के बाद शुगर स्पाइक्स को कम करता है। टाइप 2 डायबिटीज को प्रबंधित करने में विशेष रूप से प्रभावी। 📚 अध्ययन: Metformin जितना ही प्रभावी (Metabolism, 2008) 🫀 2. हृदय स्वास्थ्य को बढ़ावा देता है LDL (खराब कोलेस्ट्रॉल) और ट्राइग्लिसराइड्स को कम करता है। HDL (अच्छा कोलेस्ट्रॉल) को बढ़ाता है। रक्त वाहिकाओं की कार्यक्षमता (endothelial function) को सुधारता है। 🧠 3. वजन घटाने और मेटाबोलिज्म सुधारने में मददगार इंसुलिन की संवेदनशीलता (sensitivity) को बेहतर बनाता है। पेट की चर्बी और BMI को कम करने में सहायक। फैट स्टोरेज से जुड़े जीन की गतिविधि को दबा सकता है। 🦠 4. एंटीमाइक्रोबियल और पेट की सेहत के लिए फायदेमंद बैक्टीरिया, फंगल और परजीवी के खिलाफ व्यापक प्रभाव। SIBO (Small Intestinal Bacterial Overgrowth) और IBS में उपयोगी हो सकता है। पेट की परत की रक्षा करता है और लीकी गट को ठीक करने में मदद करता है। 🧬 5. सूजन कम करने वाला और एंटीऑक्सीडेंट प्रभाव सूजन पैदा करने वाले साइटोकाइन्स (जैसे IL-6, TNF-α) को कम करता है। माइटोकॉन्ड्रिया की कार्यक्षमता को सुधारता है और ऑक्सीडेटिव स्ट्रेस से बचाता है। 🧠 6. मस्तिष्क की रक्षा में संभावनाएं प्रारंभिक शोध में यह पाया गया है कि बेर्बेरिन संज्ञानात्मक गिरावट (cognitive decline) को रोकने में मदद कर सकता है। यह AMPK को सक्रिय कर मस्तिष्क में सूजन को कम कर सकता है। ⚠️ सावधानियाँ और संभावित दुष्प्रभाव खुराक: सामान्यतः 500mg, दिन में 2–3 बार (भोजन के साथ लेना बेहतर) संभावित दुष्प्रभाव: पेट दर्द, कब्ज या मतली लगातार लंबे समय तक उपयोग की सिफारिश नहीं की जाती (ब्रेक के साथ लें) कुछ दवाओं के साथ प्रतिक्रिया कर सकता है, विशेषकर ब्लड शुगर या बीपी की दवाओं के साथ ✅ लाभों का सारांश ब्लड शुगर नियंत्रण कोलेस्ट्रॉल में सुधार वजन घटाने में सहायक आंतों की सेहत को बढ़ावा सूजन को कम करने वाला मस्तिष्क के लिए सुरक्षात्मक Berberine is a powerful bioactive compound extracted from several plants, including Berberis vulgaris (barberry). It has been used for centuries in Ayurvedic and Chinese medicine — and modern research is now validating many of its benefits. Here are the top science-backed benefits of berberine: 🔬 1. Lowers Blood Sugar Levels (Comparable to Metformin) Berberine activates AMPK (AMP-activated protein kinase), a metabolic master switch. Studies show it reduces fasting blood glucose, HbA1c, and post-meal sugar spikes. Particularly effective for managing type 2 diabetes. 🧪 Study: Comparable to metformin in glucose regulation (Metabolism, 2008) 🫀 2. Supports Heart Health Lowers LDL (“bad”) cholesterol and triglycerides Raises HDL (“good”) cholesterol Improves endothelial function (important for blood vessel health) 🧠 3. Aids in Weight Loss and Metabolic Function Improves insulin sensitivity Helps reduce belly fat and BMI in overweight individuals Can suppress fat storage-related gene expression 🦠 4. Antimicrobial and Gut-Healing Properties Berberine has broad-spectrum antimicrobial effects: antifungal, antibacterial, and antiparasitic May help with SIBO (Small Intestinal Bacterial Overgrowth) and IBS Improves gut barrier integrity 🧬 5. Anti-Inflammatory & Antioxidant Effects Downregulates pro-inflammatory cytokines (e.g., IL-6, TNF-α) Supports mitochondrial function and combats oxidative stress 🧠 6. Neuroprotective Potential Early studies show promise in preventing cognitive decline, possibly through AMPK activation and reduced neuroinflammation. ⚠️ Precautions & Side Effects Dosage: 500 mg 2–3x/day is common (best with meals) Possible side effects: GI discomfort, constipation, or nausea Not recommended for long-term continuous use without breaks May interact with medications (especially for diabetes or blood pressure) ✅ Summary of Benefits Blood sugar control Cholesterol improvement Fat loss support Gut health booster Inflammation reducer Cognitive support Benefits of Berberine, Berberine supplement, What is Berberine used for, Berberine for blood sugar, Berberine for weight loss, Berberine health benefits, Berberine for diabetes, Natural alternative to metformin, Berberine dosage and uses,

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Shark Tank Episode With Keto Diet Pills A Detailed Breakdown

🟣The ultimate guide to actual weight loss results! This one of a kind video will explore the most tried and true weight loss methods to discuss what works! ⚡Drink LMNT🔋 - Sponsored, Thank you! https://drinklmnt.com/NoLabCoatRequired https://drinklmnt.com/NoLabCoatRequired https://drinklmnt.com/NoLabCoatRequired 🟣Thank you Black Magic Design for continued creative support💛. 🟣Thank you kind sir we met in the gym. Thanks Cornell for always helping. Thank you Fit Code for being home! 🟣This video was created for folks who may not know where to start when it comes to weight loss. Sometimes we don't even know what actually gets the weight off. We made this so that you can solidify your own understanding of weight loss. Many things can lead to a smaller waistline, but trying to lose weight aimlessly can be a total waste! Use this video to establish a base of what you believe is feasible, sustainable, and effective! We used scientific studies to make quite the unique video. Most weight loss videos on the internet talk anecdote-- valuable stuff, but here's a video for the nerds! 🟣Patreon: https://patreon.com/NoLabCoatRequired 🟣instagram📸 https://www.instagram.com/nolabcoatrequired/ 🟣Cites Keto|1 https://pubmed.ncbi.nlm.nih.gov/24717684/ Keto|2 https://pubmed.ncbi.nlm.nih.gov/15148063/ Keto|3 https://pubmed.ncbi.nlm.nih.gov/20196854/ Hi-Pro|1 https://pubmed.ncbi.nlm.nih.gov/14710168/ Hi-Pro|2 https://pubmed.ncbi.nlm.nih.gov/16002798/ Hi-Pro|3 https://pubmed.ncbi.nlm.nih.gov/10375057/ Walking|1 https://pubmed.ncbi.nlm.nih.gov/28794207/ Walking|2 https://pmc.ncbi.nlm.nih.gov/articles/PMC8840715/ HIIT|1 https://www.sciencedirect.com/science/article/pii/S1728869X14000033 HIIT|2 https://pmc.ncbi.nlm.nih.gov/articles/PMC4967258/ Fast|1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7468742/ Lo-Carb|1 https://pubmed.ncbi.nlm.nih.gov/12761365/ Cardio|1 https://pubmed.ncbi.nlm.nih.gov/12861232/ Cardio|2 https://pubmed.ncbi.nlm.nih.gov/36820332/ Cardio|3 https://pubmed.ncbi.nlm.nih.gov/25722378/ Plant-based|1 https://pubmed.ncbi.nlm.nih.gov/30223451/ Low-cal|1 https://pubmed.ncbi.nlm.nih.gov/30470804/ Strength|1 https://pubmed.ncbi.nlm.nih.gov/28514618/ Strength|2 https://pubmed.ncbi.nlm.nih.gov/23006411/ a) https://pmc.ncbi.nlm.nih.gov/articles/PMC8684475/ b) https://pmc.ncbi.nlm.nih.gov/articles/PMC4018950/ c) https://pubmed.ncbi.nlm.nih.gov/29494664/ d) https://pubmed.ncbi.nlm.nih.gov/35373905/ e) https://pubmed.ncbi.nlm.nih.gov/23651522/ f) https://pmc.ncbi.nlm.nih.gov/articles/PMC9285060/ g) https://pubmed.ncbi.nlm.nih.gov/25882384/ ; https://pubmed.ncbi.nlm.nih.gov/23006411/ 🟣My Personal Notes: https://quizlet.com/988974481/every-leading-weight-loss-method-explained-ranked-based-on-science-flash-cards/?i=1bn0bq&x=1jqt 🟣Timestamps: 0:00 Every weight loss method explained 1:22 Keto diet 4:52 High Protein and Carnivore 8:48 Walking 12:57 HIIT 17:23 Intermittent Fasting 19:33 Low-Carb 24:23 Plant-based 28:37 Calorie restriction 30:18 Strength training

Combining Keto Gummies And Apple Cider Vinegar For Optimal Results

Daftar GGL sekarang: https://ggl.life/pages/start?utm_source=yt+dienandmey&utm_medium=organic&utm_campaign=caption&utm_content=web+start&utm_term=7+juli+shorts - Cara membedakan kehilangan masa otot vs lemak / cara menurunkan berat badan - Cara pintar hidup sehat. Program diet online bikin langsing tanpa pakai obat. Program langsing untuk turunkan berat badan dan lingkar badan untuk perempuan. Daftar sekarang: https://ggl.life/pages/start?utm_source=yt+dienandmey&utm_medium=organic&utm_campaign=caption&utm_content=web+start&utm_term=7+juli+shorts - #dietonline #gakgendutlagi #langsing

Diet And Weight Loss Andrew Lessman

The Intersection of Keto and CBD: Unlocking Benefits for Modern Living

In the fast-paced world we live in today, stress management and weight control are two of the most significant concerns for many individuals. As more people seek holistic remedies and healthier lifestyles, the ketogenic diet and cannabidiol (CBD) have emerged as popular options. Each, on their own, offers benefits that can help modern individuals cope with stress and promote a healthier weight. But what happens when we combine these two powerful resources into a single, convenient product—keto + CBD gummies? This innovative combination is stirring excitement as it promises to deliver a blend of stress-relief and fat-burning benefits that are not only appealing but also effective.

The ketogenic diet, characterized by high-fat and low-carbohydrate intake, aims to induce a metabolic state known as ketosis, where the body burns fat for fuel instead of carbohydrates. This can lead to impressive fat loss and improvements in mental clarity, energy levels, and even mood. On the other hand, CBD is a compound derived from cannabis that has been touted for its potential therapeutic benefits, which include anxiety relief, anti-inflammatory properties, and pain management. By merging these two health trends, keto + CBD gummies offer a new approach to improving overall well-being.

As we delve deeper into the benefits of incorporating keto + CBD gummies into your lifestyle, we will explore three surprising advantages that have captured the attention of health enthusiasts and wellness seekers alike. From supporting stress management to enhancing fat-burning efforts, these gummies may provide a solution that goes beyond conventional methods for achieving a balanced life. Incorporating these gummies may not only simplify your wellness practices but also lead to a holistic approach to stress reduction and weight management tailored for the fast-paced, demanding lives we lead today.

1. Enhanced Stress Management: CBD’s Calming Properties

One of the primary benefits of CBD is its profound effect on stress and anxiety. Research indicates that CBD interacts with the endocannabinoid system in our bodies, which plays a crucial role in regulating various physiological processes, including mood and stress responses. By modulating the levels of serotonin in the brain, CBD can contribute to feelings of calm and well-being. When combined with the ketogenic diet, which helps stabilize blood sugar levels and reduce cravings, the result is a broader, more rounded approach to managing stress.

Many individuals on a ketogenic diet often report feeling more balanced and resilient. This can be attributed to the improved energy levels and mental clarity associated with ketosis. By adding CBD to the mix through gummies, users can experience an enhanced ability to cope with daily stressors. The convenience and tastiness of gummies can encourage more consistent use compared to other methods of consuming CBD, leading to more significant stress relief over time. Essentially, keto + CBD gummies become an easy snack for those seeking to unwind, making it easier to prioritize mental health.

Furthermore, the combination of CBD and a ketogenic lifestyle may have synergistic effects. While the keto diet helps reduce anxiety-inducing blood sugar fluctuations, CBD promotes relaxation and emotional stability. This dual-action can be particularly beneficial in high-stress scenarios, whether it’s at work or in personal life. As stress levels decrease, individuals may find themselves better equipped to focus on tasks, engage positively with others, and tackle challenges with a level-headed approach.

2. Support for Weight Management: Fat Burning Benefits

The ketogenic diet is a proven method for weight loss, primarily due to its ability to induce ketosis. When the body shifts from using glucose to burning fat for energy, it naturally starts to reduce fat stores. However, achieving and maintaining ketosis can sometimes be challenging. This is where the combination of keto + CBD gummies can bring additional support for those aiming to shed extra pounds. CBD’s potential role in assisting weight management is an exciting avenue to explore.

Studies have shown that CBD may help regulate fat metabolism and stimulate the browning of adipose tissue, which is crucial for fat burning. This means that, in conjunction with a ketogenic diet, CBD may not only help sustain fat loss but also enhance the body’s ability to utilize fat as an energy source more effectively. The result is an optimized process for burning fat, particularly for those who are committed to a low-carb lifestyle.

Moreover, CBD can play a role in appetite regulation. One common challenge of dieting is dealing with cravings and feelings of hunger, which can lead to overindulgence and derail progress. By incorporating keto + CBD gummies, individuals may find an easier time managing cravings, supporting their dietary goals without stress. This combination can empower users to remain focused on their weight loss journey, helping them make healthier choices and sustain their efforts over the long term.

3. Increased Focus and Clarity: The Cognitive Benefits of CBD

In addition to its physical benefits, the combination of keto and CBD also has positive implications for cognitive function. Individuals often seek out the ketogenic diet for its ability to enhance mental clarity and cognitive performance. When fat is used as the primary fuel source, particularly in the form of ketones, the brain experiences a boost in efficiency. When you add CBD into the equation, you may find that not only does your body benefit, but your mind does too.

CBD has been noted for its neuroprotective qualities, which can help optimize brain health. By potentially reducing inflammation and promoting repair within the neuronal pathways, CBD can enhance cognitive function and memory retention. For those who employ a ketogenic diet, which already sharpens mental focus, combining it with CBD may compound these advantages, creating a powerful synergy that supports both mental agility and emotional well-being.

Moreover, the stress-reducing effects of CBD can lead to lower levels of mental fatigue and distraction. Stress often clouds cognition, making it difficult to concentrate on tasks. By alleviating stress, the gummies could help create an environment where mental tasks and decision-making are handled more efficiently. Ultimately, keto + CBD gummies can serve as a beneficial tool for students, professionals, and anyone looking to enhance their mental performance while maintaining a keto lifestyle.

Addressing Concerns and Common Questions

As consumers become more interested in integrating keto + CBD gummies into their daily routines, they may have questions regarding their safety, legality, and overall efficacy. First and foremost, it’s crucial to address the legality of CBD. In many places, CBD derived from hemp is legal as long as it contains less than 0.3% THC. However, local laws may vary, so it is essential for consumers to verify the regulations in their area.

Another common inquiry is about the safety and side effects of CBD. Generally, CBD is considered safe for most people in moderate amounts, but some individuals may experience mild side effects like drowsiness or gastrointestinal issues. It’s wise to consult with a healthcare professional before incorporating CBD into your routine, especially if you’re taking other medications or have underlying health concerns.

Lastly, consumers often wonder about the effectiveness of keto + CBD gummies. Many anecdotal accounts and preliminary studies indicate positive outcomes concerning stress relief and metabolic support with CBD when used alongside a ketogenic diet. However, individual results may vary depending on factors like body chemistry, lifestyle, and adherence to the keto diet. Like any supplement, the gummies should be used as part of a balanced approach to diet and exercise.