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Obesity specialist Dr Holly Lofton reveals how she chooses the right GLP-1 for each patient, and the importance of staying on label. https://www.medscape.com/viewarticle/1000524?src=soc_yt -- TRANSCRIPT -- Hi. I'm Dr Holly Lofton. I'm a board-certified obesity medicine specialist, and I direct the medical weight management program at NYU Langone Health. With all the excitement about GLP-1 agonists, I get many questions from providers about which antiobesity drug they should prescribe. I'll tell you the methods that I use to determine which drug is best for which patient. Of course, we want to make sure that we're treating the right condition. If the patient has type 2 diabetes, we tend to give them medication that is indicated for type 2 diabetes. Many GLP-1 agonists are available in a diabetes version and a chronic weight management or obesity version. If a patient has diabetes and obesity, they can receive either one. If a patient has only diabetes but not obesity, they should be prescribed the diabetes version. For obesity without diabetes, we tend to stick with the drugs that are indicated for chronic weight management. Let's go through them. Exenatide. In chronological order of approval, the first GLP-1 drug that was used for diabetes dates back to exenatide (Bydureon). Bydureon had a partner called Byetta (also exenatide), both of which are still on the market but infrequently used. Some patients reported that these medications were inconvenient because they required twice-daily injections and caused painful injection-site nodules. Diabetes drugs in more common use include liraglutide (Victoza) for type 2 diabetes. It is a daily injection and has various doses. We always start low and increase with tolerance and desired effect for A1c. Liraglutide. Victoza has an antiobesity counterpart called Saxenda. The Saxenda pen looks very similar to the Victoza pen. It is a daily GLP-1 agonist for chronic weight management. The SCALE trial demonstrated 8%-12% weight loss with Saxenda. Those are the daily injections: Victoza for diabetes and Saxenda for weight loss. Our patients are very excited about the advent of weekly injections for diabetes and weight management. Ozempic is very popular. It is a weekly GLP-1 agonist for type 2 diabetes. Many patients come in asking for Ozempic, and we must make sure that we're moving them in the right direction depending on their condition. Semaglutide. Ozempic has a few different doses. It is a weekly injection and has been found to be quite efficacious for treating diabetes. The drug's weight loss counterpart is called Wegovy, which comes in a different pen. Both forms contain the compound semaglutide. While all of these GLP-1 agonists are indicated to treat type 2 diabetes or for weight management, Wegovy has a special indication that none of the others have. In March 2024, Wegovy acquired an indication to decrease cardiac risk in those with a BMI ≥ 27 and a previous cardiac history. This will really change the accessibility of this medication because patients with heart conditions who are on Medicare are expected to have access to Wegovy. Tirzepatide. Another weekly injection for treatment of type 2 diabetes is called Mounjaro. Its counterpart for weight management is called Zepbound, which was found to have about 20.9% weight loss over 72 weeks. These medications have similar side effects in differing degrees, but the most-often reported are nausea, stool changes, abdominal pain, and reflux. There are some other potential side effects; I recommend that you read the individual prescribing information available for each drug to have more clarity about that. It is important that we stay on label for using the GLP-1 receptor agonists, for many reasons. One, it increases our patients' accessibility to the right medication for them, and we can also make sure that we're treating the patient with the right drug according to the clinical trials. When the clinical trials are done, the study populations demonstrate safety and efficacy for that population. But if we're prescribing a GLP-1 for a different population, it is considered off-label use. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/1000524?src=soc_yt

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Are you struggling to lose weight and achieve your desired level of fitness?

If so, you are not alone. Many people find it challenging to shed those extra pounds and maintain a healthy lifestyle. With so many diets and weight loss supplements on the market, it can be overwhelming to find the right solution that works for you. However, one product that has been gaining popularity in the health and wellness community is Dr. Choice Keto Gummies.

Dr. Choice Keto Gummies are doctor-recommended for effective ketosis, making them a safe and reliable option for anyone looking to lose weight and improve their overall health. In this article, we will explore the benefits of Dr. Choice Keto Gummies, how they work, and why they are a popular choice among health-conscious individuals.

The Science Behind Dr. Choice Keto Gummies

Dr. Choice Keto Gummies are formulated with ingredients that are scientifically proven to promote ketosis in the body. Ketosis is a natural metabolic state where the body burns fat for fuel instead of carbohydrates. This process can lead to weight loss, increased energy levels, and improved mental clarity.

One of the key ingredients in Dr. Choice Keto Gummies is beta-hydroxybutyrate (BHB), which is a ketone body that helps the body enter into ketosis more quickly. BHB is also known to reduce hunger cravings and provide a steady source of energy throughout the day.

In addition to BHB, Dr. Choice Keto Gummies contain other natural ingredients such as green tea extract, apple cider vinegar, and coconut oil. These ingredients work together to support the body’s natural fat-burning processes and promote overall wellness.

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There are many benefits to incorporating Dr. Choice Keto Gummies into your daily routine. First and foremost, these gummies can help you reach your weight loss goals more effectively than diet and exercise alone. By promoting ketosis in the body, Dr. Choice Keto Gummies can help you burn fat for fuel and shed those extra pounds.

Dr. Choice Keto Gummies can also help improve your energy levels, making it easier to stay active and focused throughout the day. Many people report feeling more alert and mentally sharp after taking these gummies, which can lead to increased productivity and overall well-being.

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Another benefit of Dr. Choice Keto Gummies is that they can help reduce cravings and support healthy eating habits. By suppressing appetite and reducing hunger pangs, these gummies can make it easier to stick to a healthy diet and avoid overeating.

How to Use Dr. Choice Keto Gummies

Using Dr. Choice Keto Gummies is simple and convenient. Simply take the recommended dosage as directed on the packaging, typically 1-2 gummies per day. It is best to take the gummies with a glass of water and before meals to maximize their effectiveness.

For best results, it is recommended to incorporate Dr. Choice Keto Gummies into a healthy diet and exercise routine. Regular physical activity and a balanced diet can help optimize the benefits of these gummies and support your weight loss goals.

It is important to note that individual results may vary, and it is always best to consult with a healthcare professional before starting any new supplement regimen. While Dr. Choice Keto Gummies are generally safe for most people, those with underlying health conditions or allergies should exercise caution and seek medical advice.

Final Thoughts on Dr. Choice Keto Gummies

In conclusion, Dr. Choice Keto Gummies are a doctor-recommended option for anyone looking to achieve effective ketosis and reach their weight loss goals. With their scientifically proven ingredients and numerous benefits, these gummies are a safe and reliable choice for promoting overall health and wellness.

Whether you are new to the keto diet or have been following it for some time, Dr. Choice Keto Gummies can help support your journey to a healthier and happier lifestyle. Give them a try today and experience the difference for yourself!

Remember to always consult with a healthcare professional before starting any new supplement regimen and listen to your body’s needs throughout the process. With dedication and commitment, you can achieve your weight loss goals and improve your quality of life with the help of Dr. Choice Keto Gummies.

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