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About taking prescription meds for weight loss, Dr. Manuel Torres, Family Medicine Physician at Baptist Health Primary Care, says what may work for one person is not necessarily going to work for all people. "There are medications that are indicated for obesity, there are medications that have different classifications," he explains and points out some of those medications may not be indicated for adolescents.

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Obesity is a global epidemic with more than a quarter of the population dealing with this metabolic syndromeWhile there are tens of thousands of solutions to suppress your weight/make you lose weight, 99% of them are band-aid solutions & do not focus on what makes you obese. Those companies &/or coaches, it is a financial model! You need to maintain your weight, you need to pay them every month to subscribe to their fad diet solutions & working schedules/plans. What causes Obesity? It is low grade chronic inflammation! So you must be wondering how inflammation in your intestines can make you gain weight? There is whole science behind & most of the biological decisions inside our body are driven by our microbiome. You may blame energy metabolism & try to create that energy deficit by eating less & burning more but energy metabolism is not about this mathematical equation. There is a web of molecular features & pathways driven by interaction between your microbiome & external environment & nutrition choices. These microbes impact/produce certain protein /hormones such as GLP-1, PYY Ghrelin & Leptin that impacts your satiety & hunger responses. While these are not the only pathways! There are multiple other interactions such as production of nitric oxide & expression of Nitric Oxide synthase that can impact your weight management & make you develop obesity However, new age medical weight loss companies have made you believe that anti-obesity drugs such as GLP-1 receptor agonists can make you lose weight. This is far away from reality -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. Myself & Sakshi discuss today what could render GLP-1 drug ineffective We at Genefitletics measures each of these gut & oral microbiome pathways to understand the changes in biology & chemistry before & during disease onset & provide interventions to bring your body back into homeostasis position Citations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793908/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021470/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833664/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268073/

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