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Revolutionizing Obesity Treatment: Connecticut's Bold Move and Pharma's Power Plays In this episode of The Downsize News, dated Monday, July 14th, hosts Laraine and Christopher Durham delve into groundbreaking developments in the world of GLP-1 medications, which have significantly impacted their personal weight loss journeys. They start with Connecticut's recent legislative move to manufacture generic versions of GLP-1 drugs, pending federal approval, aimed at reducing costs and expanding access. This could set a precedent for states like California, Louisiana, Washington, North Carolina, West Virginia, and Pennsylvania amidst skyrocketing GLP-1 expenditures. Next, Novo Nordisk's aggressive marketing campaign for Wegovy during the NBA finals is highlighted, alongside this pharmaceutical giant's bid for a higher dose approval in Europe. This newer dose has shown substantial promise in clinical trials, potentially signaling further advancements for US markets. Eli Lilly, in a defensive maneuver, is increasing its US imports from Ireland to buffer against potential trade disruptions, illustrating the global implications of GLP-1 drug production and distribution. Additionally, Novo Nordisk's $2.3 billion investment in Italian manufacturing marks its effort to maintain a competitive edge in the European market. Other stories include promising preclinical studies on the new combination drug Cagrisema, which merges amylin analog with Semaglutide, showing enhanced weight loss mechanisms that counter normal metabolic adaptation. Kate Farms' introduction of a new high-protein, zero-sugar nutritional shake and Ipsos' innovative 'GLP-1 Persona Bot' for better consumer insights underscore the market's evolving landscape. Eli Lilly's donation of a mobile clean room lab to Purdue University aims to train future professionals in sterile compounding, crucial for advancing pharmaceutical manufacturing. The episode wraps up with the Durhams urging viewers to visit their Amazon store for curated GLP-1 user products, supporting both their channel and the weight loss journey of their community. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store As an Amazon Associate I earn from qualifying purchases. DOWNSIZED WEBSITE: https://thedownsized.org/ BOOK THE DOWNSIZED AT SEA CRUISE 2026: https://thedownsized.org/downsized-at-sea-2026/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:18 Connecticut's Bold Move on GLP-1 Generics 06:34 Novo Nordisk's Wegovy Ad Blitz 10:21 Novo Nordisk Submits Higher Dose Wegovy to EU 13:03 Eli Lilly's Strategic Moves 15:13 Novo Nordisk's Expansion in Italy 16:53 Preclinical Study on Cagrisema and Weight Loss 20:07 Novo Nordisk's Investment in China 23:03 Kate Farms' New High-Protein Shake 23:59 Ipsos' GLP-1 Persona Bot 26:11 Eli Lilly's Mobile Clean Room Lab Donation 27:41 Conclusion and Final Thoughts

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Fight Sarcopenia with body recomposition, build new muscle and lose body fat at the same time. Today we are going to talk about body recomposition. As we age we might feel more like we are suffering from body decomposition. With are bodies slowly starting to decompose right before are very eyes. They actually have a term for this called sarcopenic obesity. Which is really just the reduction of muscle mass with an increase in body fat. When we are recompositioning our bodies we are doing just the opposite by increasing our lean body mass while reducing body fat. Essentially reversing sarcopenia If you are interested in losing body fat and adding muscle, please email me at [email protected] for information on my personal training services. Facebook; https://www.facebook.com/Fit-and-50-548844435514900/ My Amazon page link; https://www.amazon.com/shop/fitand50 My Affiliate link to Lebert for their Equalizer bars and more; http://www.easywebautomation.com/app/?af=1679568 and use the discount code LFI20 you will receive 20 dollars off your purchase Fight Sarcopenia with body recomposition, build new muscle and lose body fat at the same time I’ve quoted lots of studies on this channel that have shown that we can get fit and build muscle at any age. And I’ll put another meta analysis at the bottom of the description that looked at a group of studies done on people between the ages of 50 and 67. This meta analysis was on inexperienced lifters without the aid of any anabolic hormone treatments. Some of the workouts they had the test subjects do were pretty poor programs and despite this they still managed to improved their lean body mass by 2.5 pounds in just over 20 weeks. Last time I did a video on body recomposition I was 52. I’m 54 now and still adding new muscle to my frame while staying relatively lean. Now if you are at a good body weight for your height, but find yourself in that skinny fat zone then you are a perfect candidate for body recomposition you won’t even necessarily need to go into a calorie deficit to lose body fat. But you will need to stay at least in maintenance calories and improve the quality of your diet along with being consistent with a progressive weight training program. But more on this in a little bit. I want to talk to everyone with over a 40” waist. You Too can build muscle and lose body fat at the same time, but for you it is more important that you are in a calorie deficit as your bodies will function much better on a hormonal level under a 40 inch waist . And hormones like growth hormone continue to improve with each centimetre your waist goes down. We may not have the raging hormones we had when we were young, but we can optimize what we have by managing our weight along with a good diet and regular progressive exercise. The heart foundation states that men with a waist size of 37 inches or over are at an increased health risk. So I would recommend that you continue to focus on weight loss and stay in a bit of a calorie deficit at least until you are under the 37 inches. This doesn’t mean you might not want to lose a bit more weight, but at least this gets you into a healthy zone to build muscle. Of course you should be weight training the entire time you are losing weight. As you can still build muscle during this time especially if you don’t cut your calories to drastically. A pound a week is a good average. When it comes to fighting sarcopenia, What we eat is a big part of the picture and the 2 things I find we tend to neglect the most is protein and veggies. For protein I don’t like recommendations based on bodyweight as a person with a high body fat percentage will require less protein than someone with less body fat. You can make the recommendation based on lean body mass, but again short of getting a dexa scan most methods of estimating our body fat percentage can often be unreliable. And people are notoriously bad at guesstimating their own body fat levels. Which is why I prefer to use percentage of calories consumed. If you are a hard training person than you should be consuming 25 to 35 percent of your calories from protein. This does mean you need to take some time to learn what you are eating and how many calories you consume on a regular bases. The best way to do this is to log your food for a couple of months. You don’t need to log forever just long enough to understand how much your eating, calorie and macro nutrients wise. Meaning how much protein fats and carbs are you consuming. Vegetables are very filling, nutrient dense and low calorie. We should be having them at every meal, filling up half of our plate. Influence of Resistance Exercise on Lean Body Mass in Aging Adults: A Meta-Analysis https://www.bewegenismedicijn.nl/files/downloads/metaanalyse_resistance_exercise_on_lean_body_mass.pdf https://www.heartandstroke.ca/get-healthy/healthy-weight/healthy-weight-and-waist

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Transformational Weight Loss with GLP-1s: Adrian Gledhill's Journey from Biggest Loser to Long-Term Success In this episode of the Downsized Dish, host Laraine Durham speaks with Adrian Gledhill, a former contestant on the Biggest Loser TV series. The discussion delves into Adrian's lifelong struggle with weight, starting from her childhood marked by insatiable hunger and bullying, to extreme diet and exercise regimens in high school and college. Despite her rigorous efforts, including competing on the Biggest Loser, Adrian found herself repeatedly gaining back the lost weight, reaching her peak weight of nearly 330 pounds during pregnancy. Adrian also details the severe implications of gastric bypass surgery she underwent, including chronic anemia, nutrient deficiencies, and reactive hypoglycemia. The turning point came when she discovered GLP-1 medications, hailed as a 'miracle' by healthcare professionals. Adrian's experience with GLP-1 agonists, starting at 2.5mg and adjusting her dosage, significantly reduced her inflammation, improved her mental health, and resulted in a 50-pound weight loss. Adrian shares her journey towards a sustainable lifestyle, the mental adjustments of recognizing her new body, and how this has positively impacted her family's health, including her husband's significant weight loss. The episode highlights the importance of non-standard dosing and individualized approaches to using GLP-1 medications. Tune in to learn about the transformative effects of GLP-1 agonists on overcoming severe weight struggles, particularly for those battling chronic inflammation and autoimmune issues. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at... DOWNSIZED WEBSITE: https://thedownsized.org/ DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store JOIN CLUB DOWNSIZED: @thedownsized FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction to the Downsized Channel 01:04 Meet Adrian Gladhill: From Biggest Loser to GLP-1 Journey 01:28 Adrian's Early Struggles with Weight 03:16 The Biggest Loser Experience 07:39 Post-Show Challenges and Weight Regain 13:38 Exploring Carnivore Diet and Health Issues 19:21 Discovering GLP-1: A Game Changer 31:13 Life on GLP-1: Success and Reflections 33:20 Personal Experience with GLP-1 Supplements 33:50 Adjusting Dosages and Finding the Right Fit 35:19 Impact on Weight and Lifestyle 36:27 Mental Health and Food Relationship 40:30 Side Effects and Managing Them 44:20 Family Experiences and Genetic Factors 53:47 Considering GLP-1 for Adolescents 01:03:21 Final Thoughts and Community Support

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In today’s fast-paced world, maintaining a healthy weight can be a challenge for many individuals. With fad diets and weight loss supplements flooding the market, it can be overwhelming to determine the best approach for long-term weight management. One approach that has gained popularity in recent years is the combination of the ketogenic diet (keto) and apple cider vinegar (ACV). This dual approach to weight management offers a variety of advantages that can help individuals achieve their weight loss goals while improving overall health.

Improved Fat Burning

The ketogenic diet is a high-fat, low-carbohydrate diet that forces the body to burn fat for fuel, leading to weight loss. When combined with apple cider vinegar, which has been shown to increase the body’s fat-burning capabilities, the two work synergistically to enhance fat loss. ACV contains acetic acid, which has been found to increase the expression of genes that are involved in fat oxidation, ultimately helping individuals burn more fat during exercise and at rest.

Additionally, ACV has been shown to improve insulin sensitivity, which is crucial for weight loss and overall health. By improving insulin sensitivity, the body is better able to regulate blood sugar levels and reduce the risk of developing type 2 diabetes. When insulin levels are stable, the body is more efficient at burning fat for energy, making it easier to achieve weight loss goals.

Reduced Appetite and Cravings

One of the biggest challenges individuals face when trying to lose weight is controlling their appetite and cravings. The ketogenic diet has been shown to reduce hunger and cravings by stabilizing blood sugar levels and promoting satiety. When combined with apple cider vinegar, which has been found to increase feelings of fullness and reduce appetite, individuals may find it easier to adhere to their diet and consume fewer calories overall.

ACV has also been shown to lower blood sugar and insulin levels after meals, which can help prevent spikes in hunger and cravings. By consuming ACV before meals, individuals may be able to better control their appetite and reduce the likelihood of overeating, ultimately leading to weight loss.

Enhanced Digestion and Gut Health

The ketogenic diet and apple cider vinegar both offer benefits for digestion and gut health, which are essential for weight management. The keto diet eliminates processed foods and sugars that can disrupt gut bacteria and lead to digestive issues. By focusing on whole, nutrient-dense foods, individuals can improve their gut health and promote better digestion.

Apple cider vinegar is known for its ability to promote the growth of healthy gut bacteria and improve digestion. The acetic acid in ACV helps to break down food more efficiently and improve nutrient absorption, leading to better overall gut health. By incorporating ACV into a keto diet, individuals can optimize their digestion and support a healthy gut microbiome.

Increased Energy and Stamina

Many individuals report increased energy and stamina when following a ketogenic diet, as the body becomes more efficient at burning fat for fuel. When combined with apple cider vinegar, which has been found to boost energy levels and improve exercise performance, individuals may experience a further enhancement in energy and stamina.

ACV has been shown to improve endurance during exercise by enhancing the body’s utilization of fat for energy. By incorporating ACV into their daily routine, individuals may notice improved energy levels throughout the day and better performance during physical activity, ultimately supporting weight loss and overall health.

Enhanced Metabolic Health

Both the ketogenic diet and apple cider vinegar offer benefits for metabolic health, which is crucial for weight management and overall well-being. The keto diet has been shown to improve markers of metabolic health, such as blood sugar levels, cholesterol levels, and blood pressure. By reducing carbohydrate intake and promoting fat burning, individuals can support optimal metabolic function.

Apple cider vinegar has been found to improve metabolic health by reducing blood sugar and insulin levels, which can help prevent insulin resistance and metabolic syndrome. By including ACV in a keto diet, individuals can further enhance their metabolic health and support long-term weight management and overall health.

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Why Americans Are Switching To This Weight Loss Supplement

Summary

In conclusion, the combination of the ketogenic diet and apple cider vinegar offers a dual approach to weight management that provides a variety of advantages. From improved fat burning and reduced appetite to enhanced digestion and metabolic health, the keto+ACV approach can help individuals achieve their weight loss goals while improving overall health. By incorporating these two strategies into a comprehensive weight loss plan, individuals may experience lasting results and better long-term health outcomes.

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