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Christina Aguilera is getting revenge on the AMA red carpet! One year after her fuller photos hit the press, she is back at the same event looking fierce!!Christina Aguilera is getting revenge on the AMA red carpet! One year after her fuller photos hit the press, she is back at the same event looking fierce!! Hollyscoop was on the red carpet as Christina was the last celebrity to arrive. She came as the final act to take pictures, and boy did she make a statement! All eyes were on her as she showed off her drastic weight loss! Its impressive in itself, but factor in her pictures from last year. The same event, from 2012. Fresh off the release of her album Lotus, Xtina took to the 2012 AMAs in a lavender gown and a platinum blond bob wig. She received harsh criticism for the curve-loving look and even more for her eccent

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Former President Joe Biden had proposed extending Medicare coverage of drugs like Wegovy, which is currently limited to patients with diabetes or heart problems. Read more: https://www.kgw.com/article/news/nation-world/trump-administration-anti-obesity-drugs-medicare/507-57e742d6-9b15-4e2f-acdd-711c783128c7 Subscribe: https://www.youtube.com/c/KGWNews8 Watch the latest KGW newscast: https://www.kgw.com/watch Get the KGW app: https://kgw.com/appredirect

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In an office in Bagsværd near Copenhagen, young biotechnologist Lotte Bjerre Knudsen has been made project manager for a promising, but uncertain project of converting the hormone GLP-1 into a drug that can prove effective in combating the rapidly growing wave of diseases such as type 2 diabetes in the 1990s. If she fails, the project will fold. Follow Episode 2 "If you don't fix this" of this advent calender from the Novo Nordisk Foundation "The Story of GLP-1". 00:00:00 - Introduction: Lotter Knudson's project on GLP-1 00:00:03 - The aim of converting GLP-1 into a drug 00:00:21 - The high stakes of the project 00:00:46 - Initial failed experiments with native GLP-1 00:01:14 - Innovative ideas for stabilizing GLP-1 00:01:50 - Use of fatty acids and albumin for protection 00:02:06 - Issues with purifying fatty acid-bound GLP-1 00:02:22 - A small crisis meeting and the biology-chemistry interplay 00:02:37 - Breakthroughs in understanding GLP-1’s biology 00:03:07 - The built-in safety switch of GLP-1 00:03:31 - Discoveries in Copenhagen on insulin and glucagon secretion 00:04:00 - Challenges in treating people with GLP-1 00:04:08 - Discovery of DPP-4 enzyme’s role 00:04:17 - Development of DPP-4 enzyme inhibitors 00:05:01 - Historical analogies with ACE inhibitors 00:05:47 - Development of DP4 inhibitors 00:06:18 - Long-acting GLP-1 analogs and their limitations 00:06:48 - Chemistry innovations to stabilize GLP-1 00:07:02 - John Eng’s discovery of Exendin-4 from Gila monster venom 00:08:02 - Challenges faced in patenting and developing Exendin-4 00:08:42 - Collaboration with Amylin Pharmaceuticals 00:09:53 - Management challenges and a deadline to fix the GLP-1 project 00:10:06 - Revisiting the initial solutions with new resources 00:10:48 - Issues in clinical trials and correct dosing 00:11:22 - Market competition and the first GLP-1 drug approval 00:12:00 - Investor skepticism and motivation to succeed

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Shots no more? Eli Lilly’s Orforglipron is the first-ever GLP-1 weight loss treatment in pill form. No injections. Just one pill a day. And early trials show promising fat-burning results. This could redefine how we treat obesity. Coming soon in 2025? #WeightLossPill #Orforglipron #GLP1