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For this week’s Metabolic Classroom lecture, Dr. Bikman focuses on natural ways to boost GLP-1 (Glucagon-Like Peptide-1), a powerful gut hormone involved in appetite control, blood sugar regulation, and metabolic health. Ben begins by explaining that GLP-1 is secreted in response to food intake, influencing glucagon suppression, slowing gastric emptying, and activating satiety centers in the brain. However, research shows that individuals with obesity tend to have a blunted GLP-1 response, particularly after consuming carbohydrates. This means that people with obesity may not experience the same level of fullness and appetite regulation, which can contribute to overeating. Dr. Bikman then discusses concerns with GLP-1 receptor agonist medications, such as Ozempic and Wegovy. While they effectively promote weight loss, they also come with significant downsides, including loss of lean mass (up to 40% of total weight lost), increased mental health risks (depression, anxiety, and suicidal thoughts), and a return of sweet cravings over time. Additionally, 70% of people discontinue these drugs within two years, often regaining weight—primarily as fat—due to muscle loss during treatment. He then presents natural methods to enhance GLP-1 production without drugs. His lab at BYU found that Yerba Mate significantly increases GLP-1 by 40-50%, likely due to its ferulic acid content and bitter taste receptors that also reduce sweet cravings. Allulose, a rare sugar, has also been shown to stimulate GLP-1 and improve glucose control, even in individuals with type 1 diabetes. Other natural boosters include a low-carbohydrate, protein-rich diet, which triples GLP-1 levels compared to a low-fat diet, collagen peptides, which enhance GLP-1 secretion and insulin sensitivity, and quality sleep, since poor sleep is linked to impaired GLP-1 signaling and increased hunger. Dr. Bikman concludes by emphasizing that leveraging diet and lifestyle changes is the most effective and sustainable way to improve GLP-1 levels, regulate appetite, and support long-term metabolic health. While GLP-1 medications may serve a purpose, particularly for those struggling with carbohydrate cravings, they come with risks that should not be ignored. Instead, strategies such as Yerba Mate, allulose, low-carb diets, collagen peptides, and better sleep can provide natural, lasting benefits without side effects. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #GLP1 #WeightLoss #Ozempic #Wegovy #MetabolicHealth #AppetiteControl #YerbaMate #LowCarbDiet #FatLoss #Allulose #BloodSugarControl #InsulinResistance #HormonalBalance #DrBenBikman #NaturalHealth #Type2Diabetes #CollagenPeptides #KetogenicDiet #MetabolicFlexibility #HealthyLiving #GLP-1 Timestamps (approximate): 00:59 - The Role of GLP-1 in Appetite & Blood Sugar Control 02:16 - GLP-1 & Glucagon Suppression: Balancing Blood Sugar 03:24 - How GLP-1 Affects Hunger & Satiety Through the Brain 06:43 - Why Obese Individuals Have a Blunted GLP-1 Response 10:09 - GLP-1 Medications: Benefits & Serious Concerns 14:19 - Yerba Mate: A Natural GLP-1 Booster (Study from Dr. Bikman’s Lab) 16:24 - Allulose: A Rare Sugar That Enhances GLP-1 & Blood Sugar Control 18:59 - How Low-Carb Diets Naturally Boost GLP-1 by 3x 21:40 - Collagen Peptides & Their Unexpected GLP-1 Benefits 23:05 - Sleep & Circadian Rhythm’s Role in GLP-1 Regulation 24:22 - Conclusion: The Best Natural Ways to Enhance GLP-1 Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: BEN10) Ben’s favorite dress shirts and pants: https://toughapparel.com/?ref=40 (use BEN10 for 10% off) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com

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Semaglutide, a medication originally used to treat type 2 diabetes, has recently gained attention for its potential as a weight loss tool. In clinical trials, semaglutide has shown impressive results in helping individuals shed pounds and improve their overall health. But how exactly does semaglutide work for weight loss in practice? Let’s take a closer look at the mechanism behind this promising drug and how it can support your weight loss journey.

The Role of Semaglutide in Weight Loss

Semaglutide belongs to a class of medications called GLP-1 receptor agonists, which work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is naturally produced in the intestine in response to food intake and plays a crucial role in regulating blood sugar levels, insulin secretion, appetite, and food intake.

By activating the GLP-1 receptors in the brain, semaglutide helps to reduce hunger and increase feelings of fullness, leading to a decrease in food intake. This can result in a reduced calorie intake, which is essential for weight loss. Additionally, semaglutide may also slow down the emptying of the stomach, further prolonging feelings of satiety.

Moreover, semaglutide has been shown to improve insulin sensitivity and reduce inflammation in the body, both of which are beneficial for weight management and overall metabolic health. By addressing these underlying factors, semaglutide can help individuals achieve sustainable weight loss and improve their overall well-being.

How Semaglutide is Administered

Semaglutide for weight loss is typically administered as a subcutaneous injection once a week. The starting dose is low to minimize side effects and is gradually increased over time to a maintenance dose. It is important to follow your healthcare provider’s instructions carefully and not to adjust the dosage on your own.

It is also essential to combine semaglutide treatment with healthy lifestyle modifications, such as a balanced diet and regular exercise, to achieve the best results. Semaglutide is not a magic bullet for weight loss but rather a tool to support your efforts in making sustainable lifestyle changes.

Some common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation, especially during the initial stages of treatment. These side effects usually subside as your body adjusts to the medication. However, if you experience severe or persistent side effects, it is crucial to consult your healthcare provider.

Considerations Before Starting Semaglutide

Before starting semaglutide for weight loss, it is essential to discuss with your healthcare provider about your medical history, current medications, and any underlying health conditions. Semaglutide may not be suitable for individuals with a history of pancreatitis, thyroid tumors, or certain gastrointestinal disorders.

Additionally, women who are pregnant or breastfeeding should not use semaglutide, as its safety in these populations has not been established. It is crucial to use effective contraception while on semaglutide treatment to prevent unintended pregnancy.

If you have any concerns or questions about semaglutide or its potential benefits and risks, do not hesitate to talk to your healthcare provider. They can provide personalized advice and guidance based on your individual health needs and help you decide if semaglutide is the right option for you.

Monitoring and Long-Term Success with Semaglutide

Regular monitoring of your progress and overall health is essential when using semaglutide for weight loss. Your healthcare provider may recommend periodic blood tests, weight measurements, and check-ins to assess your response to the medication and make any necessary adjustments.

It is also crucial to have realistic expectations and understand that weight loss with semaglutide may vary from person and can take time. Consistency with your treatment plan and dedication to healthy habits are key to achieving long-term success with semaglutide and maintaining your weight loss in the future.

Remember that weight loss is a journey that requires patience, commitment, and support. With the help of semaglutide and a healthcare team, you can take positive steps towards a healthier weight achieving your weight loss goals and improving your overall well-being.

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Reducing belly fat is probably one of the most common goals in fitness. I get asked about this EVERY DAY. Multiple times. And while we CAN lose belly fat, we can't significantly TARGET our fat loss there with ab workouts like leg raises, situps, or crunches. "Spot reduction" with exercise is not effective.* We lose fat proportionately throughout our body with diet and exercise. Individuals do tend to store fat in different areas, but this is largely up to genetics. *I'm aware of some more recent studies that show some spot reduction by doing high-intensity workouts in an area followed by cardio. However, there aren't MANY studies about this, and it's debatable whether or not this is significantly more effective than just regular diet and exercise. It's also unknown if there were other factors in this study. It's interesting, but I'm hesitant to recommend it until we know more. Legal Notice: Consult your doctor before beginning any kind of exercise program. This video does not replace a physical therapy program or consultation with a medical professional. #hybridcalisthenics #bellyfat #fatloss #weightloss #spotreduction#stretching #bellyfatloss #burnbellyfatexercise --- belly fat, lose belly fat, belly fat loss, fat loss, burn belly fat, losing belly fat, how to actually lose belly fat, how to reduce belly fat, how to get rid of belly fat, reduce belly fat, how to burn belly fat, lose fat, how to lose belly fat, builtwithscience, jeremyethier, abs exercises, stubborn belly fat, how to lose stubborn fat, love handles, lower ab fat, lower belly fat, lose lower belly fat, how to lose fat, hiit, crunches, planks, ab workout, belly fat workout Thanks for watching! I hope this explains how to lose belly fat with a proper diet and the best flat belly workout. I’ll see you in the next video.

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