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📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com and/or 📢 Become an Insider, Ben’s website: https://www.benbikman.com In this Metabolic Classroom lecture, Ben challenges the conventional insulin-centric model of type 1 diabetes by introducing the “bi-hormonal hypothesis” proposed by Dr. Roger Unger. While insulin deficiency is a defining feature of T1DM, Dr. Bikman emphasizes the overlooked role of glucagon in driving hyperglycemia, ketone production, and muscle wasting. In normal physiology, insulin from beta cells locally suppresses glucagon from alpha cells. But in type 1 diabetes, this local regulation is lost, allowing glucagon to run unchecked—even when blood glucose is high. Ben explains how injected insulin, although lifesaving, can’t mimic the precise intra-islet insulin levels needed to suppress glucagon secretion. This mismatch helps explain why blood sugar control can remain elusive despite appropriate insulin use. Excess glucagon ramps up liver glucose output and ketogenesis, creating a more complex hormonal storm than insulin alone can calm. The lecture also explores new therapeutic strategies—including glucagon receptor blockers and GLP-1 agonists—that may help suppress glucagon more effectively. Dr. Bikman urges a shift in perspective: instead of seeing diabetes as just a disease of insulin, it’s time to recognize its bi-hormonal nature and tailor treatment accordingly. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, ad-free podcast episodes, show notes and references, online Office Hours access, Ben’s Research Review Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) In addition, our channel has first access to YouTube’s new, innovative “auto-dubbing” feature. The process currently supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. #Type1Diabetes, #T1DM, #InsulinResistance, #Glucagon, #RogerUnger, #DiabetesScience, #MetabolicHealth, #BloodSugar, #Ketones, #DiabetesEducation, #InsulinTherapy, #Endocrinology, #DiabeticKetoacidosis, #DiabetesTreatment, #DiabetesResearch, #MetabolicDisorders, #GlucoseControl, #BetaCells, #AlphaCells, #PancreaticHealth #keto #metabolicclassroom #benbikman #drbenbikman Timestamps (approximate): 00:01 – Rethinking the Insulin-Centric Model 01:04 – Dr. Roger Unger and the Bi-Hormonal Hypothesis 03:15 – Glucagon: The Forgotten Hormone 05:17 – Glucagon Physiology and Liver Function 08:23 – Pericrine Regulation in Pancreatic Islets 10:36 – What Goes Wrong in Type 1 Diabetes 12:45 – Glucagon Secretion Without Insulin 13:50 – Glucagon’s Role in Ketogenesis and Protein Breakdown 15:54 – The Limits of Injected Insulin 17:58 – Why Systemic Insulin Misses the Mark 19:10 – Explaining Glucose Variability and High Insulin Needs 21:34 – Clinical Implications of Hyperglucagonemia 23:32 – Muscle Wasting and Amino Acid Shuttling 24:29 – Blocking Glucagon: A Therapeutic Strategy 25:29 – Type 2 Diabetes and Glucagon Resistance 26:21 – Drug Therapies Targeting Glucagon 28:31 – GLP-1 Drugs as Glucagon Suppressors 29:37 – Final Thoughts: A Paradigm Shift in Diabetes Treatment Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd

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5 Plant-Based Foods That Crush Cravings and Help You Lose Weight Are cravings sabotaging your weight loss journey? In this video, we dive into 5 nutrient-dense, plant-based foods that are scientifically proven to keep you full, crush cravings, and help you stay on track. From protein-packed legumes to creamy avocados, these foods are game-changers for anyone looking to lose weight while feeling satisfied and energized. 🍎 Ready to transform your health with plant-based eating? 👉 Join The Healing Kitchen for exclusive recipes, tips, and guidance from experts who make plant-based living simple and delicious: https://www.skool.com/healing-kitchen/about 👉 Preorder your copy of Plant-Based 101: The Ultimate Guide to Mastering the Plant-Based Diet and take your first step towards mastering a healthier lifestyle today: https://www.amazon.com/dp/B0DPZ59RKT?ref_=cm_sw_r_ffobk_cp_ud_dp_FC69XF60QEJKZMFNRHG8 Don’t let cravings win—discover how these foods can fuel your weight loss success and redefine your relationship with food. Hit play now! ✨ Subscribe for more plant-based nutrition tips, recipes, and motivation! 💚 Like, comment, and share to help others crush their cravings too!

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The ketogenic diet has been gaining popularity in recent years for its ability to help people lose weight and improve their overall health. One key component of the keto diet is the use of exogenous ketones, such as Beta-Hydroxybutyrate (BHB), to help the body reach a state of ketosis more quickly. Keto BHB is a supplement that has been making waves in the health and wellness industry, and recently, it was featured on the popular TV show Shark Tank. The game-changing revelation of Keto BHB on Shark Tank has left many people curious about its effectiveness and how it can help them achieve their health goals.

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During the episode of Shark Tank where Keto BHB was featured, the entrepreneurs behind the product showcased its benefits and shared their success stories. The sharks were impressed by the science behind the product and its potential to help people lose weight and improve their energy levels. Ultimately, Keto BHB received a deal from one of the sharks, catapulting it into the spotlight and garnering attention from thousands of viewers.

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One of the key features of Keto BHB that sets it apart from other supplements is its use of high-quality ingredients that are backed by scientific research. The BHB salts in Keto BHB are designed to help your body reach ketosis faster and more efficiently, allowing you to experience the benefits of the ketogenic diet without having to strictly adhere to a low-carb, high-fat diet. This makes it easier for people to stick to their weight loss goals and enjoy the benefits of a ketosis state.

Many people who have tried Keto BHB have reported positive results, such as increased energy levels, improved mental clarity, and faster weight loss. By taking Keto BHB regularly, you can help your body burn fat for fuel instead of relying on carbs, leading to a slimmer physique and better overall health. With its convenient capsule form, Keto BHB is easy to incorporate into your daily routine, making it a simple and effective way to support your keto journey.

Frequently Asked Questions

1. Can I take Keto BHB if I’m not following a ketogenic diet?

Yes, you can still take Keto BHB even if you’re not following a keto diet. The BHB salts in the supplement can help your body reach ketosis faster, even if you’re still consuming carbs. However, for optimal results, it’s recommended to follow a low-carb, high-fat diet to reap the full benefits of Keto BHB.

2. How quickly will I see results from taking Keto BHB?

Results may vary from person to person, but many users report feeling more energized and experiencing weight loss within the first few weeks of taking Keto BHB. Consistent use of the supplement, combined with a healthy diet and exercise routine, can help you achieve your health goals more quickly.

3. Are there any side effects of taking Keto BHB?

Some people may experience mild side effects when first starting to take Keto BHB, such as gastrointestinal discomfort or headaches. These side effects are usually temporary and subside as your body adjusts to the supplement. It’s important to consult with a healthcare professional before starting any new supplement regimen to ensure it’s safe for you.

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Losing weight becomes easy when you love what you eat. I don't force down foods I hate just to hit protein goals or follow diet rules. Instead, I make delicious salmon, steak, and ground beef dishes that I genuinely enjoy. There's no reason to feel guilty for loving food or to eat anything you dislike for weight loss. Learn more on the Why We Overeat podcast, episode 272 - Breaking Free from Protein Prison.

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