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Drs Akshay Jain and Lorenzo Leggio discuss GLP-1 RA therapy and its potential to mitigate alcohol misuse syndrome. https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt --TRANSCRIPT-- Akshay B. Jain, MD: Today we are very excited to have Dr Leggio join us all the way from the National Institutes of Health (NIH). He is an addiction physician scientist in the intramural research program at NIH. Welcome, Dr Leggio. Thanks for joining us. Lorenzo Leggio, MD, PhD: Thank you so much. Jain: We'll get right into this. Your session was, in my mind, extremely informative. The session looked at glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy and its potential effects on mitigating alcohol misuse syndrome, so, reduction of alcohol addiction potentially. We've seen in some previous clinical trials, including many from your group, that alcohol use is known to be reduced — the overall risk of incidence, as well as recurrence of alcohol use — in individuals who are on GLP-1 RA therapy. Can you share more insights about the data already out there? Leggio: At the preclinical level, we have a very robust line of studies, experiments, and publications looking at the effect of GLP-1 RAs, starting from exenatide up to, more recently, semaglutide. They show that these GLP-1 RAs do reduce alcohol drinking. They used different animal models of excessive alcohol drinking, using different species — for example, mice, rats, nonhuman primates — models that reflect the excessive alcohol drinking behavior that we see in patients, like physical alcohol dependence or binge-like alcohol drinking, and other behaviors in animal models that reflect the human condition. In addition to that, we recently have seen an increase in human evidence that GLP-1 RAs may reduce alcohol drinking. For example, there is some anecdotal evidence and some analyses using social media showing that people on GLP-1 RAs report drinking less alcohol. There are also some pharmacoepidemiology studies which are very intriguing and quite promising. In this case, people have been looking at electronic medical records; they have used the pharmacoepidemiology approaches to match patients on GLP-1 RAs because of diabetes or obesity, and have compared and matched to patients on different drugs as the controls. A study was recently published in Nature Communications by a group in Cleveland in collaboration with Dr Nora Volkow from the National Institute on Drug Abuse. This study shows the association between being on a GLP-1 RA and the lower incidence of alcohol use disorder and lower drinking. There is also some promise from prospective randomized clinical trials. In particular, there was one clinical trial from Denmark, a well-known and -conducted clinical trial where they looked at exenatide, and they didn't see an effect of exenatide compared with placebo in the main analysis. But in a subanalysis, they did see that exenatide reduced alcohol drinking, but only in patients with alcohol use disorder and obesity. This suggests that these medications may work for some patients and not for other patients. That's fine, because just like in any other field in medicine, including diabetes, obesity, hypertension, Parkinson's, and depression, not all medications work for everybody. If these medications will work for alcohol addiction, we do not expect that they will work for everybody. One ongoing question in the field is to try to identify the phenotypes or the subgroup of people who may be more responsive to these medications. Jain: This is such a fascinating field, and all these studies are coming out. In your review of all the literature so far, do you think this is dose dependent? Also, we see that, for instance, with certain individuals, when they take GLP-1 RA therapy, they might have a lot of gastrointestinal (GI) side effects. Recent studies have shown that the rate of these GI side effects does not necessarily correlate with the amount of weight loss. In the alcohol addiction field, do you think that the GI side effects, things like nausea, could also have a potential role in mitigating the alcohol addiction? Leggio: This is a great question. They may play a role; they may contribute, too, but we don't think that they are the driving mechanism of why people drink less, for at least a couple of reasons. One is that, similar to the obesity field, the data we have so far don't necessarily show a relationship between the GI side effects and the reduction in drinking. Plus, the reduction in drinking is likely to happen later when many GI side effects are gone or attenuated. Transcript in its entirety can be found by clicking here: https://www.staging.medscape.com/viewarticle/glp-1-ra-therapy-alcohol-use-disorder-2024a1000fur?src=soc_yt
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🔥 Week 9 & 10 on Ozempic (Semaglutide) | Weight Loss Results & Side Effects 🔥 Hey everyone! 👋 Welcome back to my Semaglutide (Ozempic) journey! 💉 In this video, I’m sharing my real, unfiltered experience from Weeks 9 & 10 – the weight loss results, how my body’s responding, and those unexpected side effects that kicked in 😬. 📉 Total Weight Lost So Far 💬 How my appetite has changed 🤢 Side effects – the good, the bad, and the weird 💪 Energy levels, mood, and motivation 🧠 Mental and emotional impact of this phase Whether you’re just starting Ozempic or considering Semaglutide for weight loss, I hope this update helps you feel informed and supported on your own journey. Let’s do this together! 💚 👇 Drop your questions or share your journey in the comments! ✨ Don’t forget to LIKE 👍, SUBSCRIBE 🔔, and SHARE 💌 for weekly updates! #OzempicJourney #SemaglutideWeightLoss #OzempicResults #Week9and10 #WeightLossUpdate #OzempicSideEffects #GLP1Journey #LoseWeightWithMe #HealthJourney #RealResults #WeightLossSupport #FitnessMotivation
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Chrissie Swan, an Australian television and radio personality, has been on a remarkable weight loss journey with the help of the Impact Keto program. Her transformation has inspired many of her fans and followers who have witnessed her incredible progress and dedication to healthier living.
Personal Struggles
Chrissie Swan has been open about her struggles with weight throughout her career in the public eye. She has shared her battles with emotional eating and body image issues, which have affected her self-esteem and overall well-being.
However, with the support of the Impact Keto program, Chrissie has been able to make positive changes in her life and take control of her health and fitness.
She has found a new sense of confidence and empowerment as she continues to shed pounds and improve her overall health with the guidance of the Impact Keto team.
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Impact Keto Program
The Impact Keto program is a ketogenic diet plan that focuses on low-carb, high-fat foods to promote weight loss and overall health. Chrissie Swan has credited the program for helping her achieve her weight loss goals and transform her lifestyle.
By following the Impact Keto program, Chrissie has been able to fuel her body with nutritious foods while still enjoying delicious meals and snacks. The program has helped her break free from unhealthy eating habits and develop a more positive relationship with food.
Chrissie has also found success with the program’s structured meal plans and ongoing support from nutritionists and coaches who have helped guide her through her weight loss journey.
Transformation and Progress
Since starting the Impact Keto program, Chrissie Swan has made significant progress in her weight loss journey. She has lost a substantial amount of weight and inches off her waist, which has led to a noticeable transformation in her appearance and overall health.
Her energy levels have increased, and she has reported feeling more confident and comfortable in her own skin. Chrissie’s dedication to the program and commitment to her health and well-being have truly paid off, as she continues to see results and maintain her progress.
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By sharing her experiences and progress, Chrissie has shown that it is never too late to make a change and prioritize your health and well-being. Her journey serves as a beacon of hope for those who are looking to start their own weight loss journey and improve their overall quality of life.
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Transforming Lives at Scottsdale Weight Loss Center
The Scottsdale Weight Loss Center stands as a beacon of hope for individuals seeking significant weight loss transformations, specifically guiding them through the intricate journey of shedding over 20 pounds. In today’s fast-paced world, where healthy lifestyles often take a backseat, this center offers proven methods tailored to meet diverse individual needs. Understanding that weight loss is more than just a number on the scale, the Scottsdale Weight Loss Center integrates a holistic approach that encompasses physical health, emotional well-being, and lifestyle changes, fostering sustainable habits rather than quick fixes. The center is equipped with a team of professionals dedicated to guiding, supporting, and empowering clients throughout their weight loss journey.
The oppressive stigma surrounding obesity and weight gain often paralyzes individuals from pursuing their goals. The Scottsdale Weight Loss Center acknowledges this emotional plight and incorporates mental health support as part of its foundational programs. Unlike many conventional weight-loss programs that focus solely on diet and exercise, the Scottsdale center promotes a supportive community environment that encourages open discussions about personal struggles and triumphs. This approach sets it apart as a sanctuary for many who feel isolated in their weight loss journeys. Clients are not merely numbers; they are valued individuals who are recognized for their unique challenges.
The center offers five scientifically backed, individualized programs designed meticulously to facilitate substantial weight loss while ensuring clients maintain a healthy and balanced lifestyle. Each program underscores the importance of personalized assessments, nutritional education, and physical activity plans tailored specifically for each client’s body type and lifestyle. Coupled with the ongoing support and accountability, the Scottsdale Weight Loss Center sets the stage for meaningful transformations, enabling clients not only to reach their weight loss goals but to sustain them long-term. It is this blend of scientific strategy, compassionate understanding, and community support that has established the Scottsdale Weight Loss Center as a leader in effective weight loss solutions.
Program One: Personalized Nutritional Therapy
The first program offered at the Scottsdale Weight Loss Center involves personalized nutritional therapy that emphasizes the vital role of diet in weight loss. Clients undergo thorough assessments to identify their unique nutritional needs and dietary preferences. Once these needs are established, registered dietitians collaborate with clients to create tailored meal plans, which prioritize whole foods and balanced macronutrients. The focus is on sustainable eating habits rather than restrictive diets, enabling clients to enjoy their meals while making healthier choices. This approach has proven effective for clients seeking to achieve over 20-pound transformations, as they discover that weight loss is not solely about cutting calories but about nourishing the body with the right foods.
Education is a cornerstone of this program. Clients learn about the nutritional value of different food groups, portion sizes, and how to make informed choices while dining out or cooking at home. Workshops and interactive sessions with dietitians provide clients with tools and knowledge, allowing them to confidently navigate their diets. This educational aspect not only motivates clients but also empowers them to take charge of their health. Furthermore, the program highlights the importance of mindfulness in eating habits, encouraging participants to develop a healthier relationship with food and understand their hunger cues better.
Personalized nutritional therapy also extends beyond meal planning. Regular check-ins with dietitians ensure that clients remain on track and address any challenges they may encounter. This ongoing support reinforces accountability and promotes long-lasting habits. Many clients have reported greater emotional satisfaction and physical well-being as they embrace their new dietary routines. By focusing on nourishing foods rather than limitations, this program positions clients for success both in their immediate weight loss goals and for sustained health in the future.
Program Two: Comprehensive Fitness Coaching
The second transformative program at the Scottsdale Weight Loss Center focuses on comprehensive fitness coaching, which is designed to introduce clients to well-rounded exercise regimens tailored to their individual capacities and preferences. Understanding that weight loss involves burning more calories than one consumes, the center offers a variety of exercise options that include strength training, cardiovascular workouts, and flexibility exercises. Clients work closely with certified personal trainers who assess their current fitness levels and create customized training plans that promote gradual progression.
This program emphasizes the importance of making exercise enjoyable. Personal trainers at the Scottsdale Weight Loss Center encourage clients to identify activities they love—be it group classes, jogging, or yoga—which increases adherence to the fitness program. Motivation and enjoyment are critical elements in sustaining any workout plan, and the center works hard to incorporate those aspects. Moreover, clients are equipped with strategies to overcome common barriers to exercise such as type of exercise, accessibility, and time constraints, ensuring they find a fitness routine that seamlessly integrates into their lives.
<p-Regular fitness sessions include education on proper form and technique, thereby reducing the risk of injury and enhancing the effectiveness of the workouts. Additionally, group sessions foster a sense of community, prompting participants to support and motivate one another. As clients witness their physical improvements and gain confidence in their abilities, they often find themselves inspired to push their limits further. With regular assessments and feedback, this comprehensive coaching program continually adapts to the evolving needs of clients, resulting in effective and sustainable weight loss outcomes.
Program Three: Behavioral Modification Strategies
Understanding that mental and emotional well-being is crucial for successful weight loss, the Scottsdale Weight Loss Center incorporates behavioral modification strategies as a core component of its programs. This innovative approach involves recognizing the psychological factors that contribute to unhealthy eating habits and lifestyles. Through workshops and individual counseling sessions, clients are encouraged to explore the reasons behind their food choices, identify emotional triggers, and develop healthier coping mechanisms.
Behavioral modification not only focuses on changing how clients interact with food but also emphasizes the importance of establishing a routine that fosters healthy behaviors. Clients learn to set realistic goals, develop positive affirmations, and create action plans to overcome obstacles that may arise on their weight loss journey. This program empowers individuals to cultivate mindfulness, enhancing self-awareness, and promoting a proactive approach to health. Clients often express that these newfound skills extend beyond their eating habits, positively influencing various aspects of their lives.
Moreover, the psychologists and counselors at the Scottsdale Weight Loss Center facilitate group therapy sessions that provide a supportive environment for clients to share their experiences. Engaging in discussions with others facing similar challenges alleviates feelings of isolation and cultivates a sense of belonging. This community-centric approach encourages accountability and motivation, ultimately enhancing long-term commitment to healthier living. By empowering clients to reshape their mental frameworks surrounding food and self-image, the Scottsdale Weight Loss Center lays the groundwork for sustained success in weight loss and overall well-being.
Program Four: Medical Monitoring for Safe Weight Loss
The Scottsdale Weight Loss Center prioritizes safety throughout the weight loss journey. The medical monitoring program is designed specifically for clients whose health conditions necessitate a more closely managed approach to weight loss. This program includes consultations with healthcare professionals who assess clients’ medical histories and current health statuses to tailor a weight loss plan that is both effective and safe.
Clients participating in this program benefit from regular health screenings, nutritional assessments, and monitoring of vital signs. This level of oversight is crucial for individuals who may be managing chronic conditions such as diabetes or hypertension. By closely monitoring progress and health metrics, healthcare professionals can adjust dietary and fitness plans to ensure optimal results and avoid potential health risks. This proactive medical supervising also provides peace of mind for clients, enabling them to focus solely on their weight loss objectives.
The medical monitoring program instills a sense of confidence in clients. Knowing that they have medical support allows individuals to pursue their weight loss goals with less fear of setbacks. Regular health check-ins offer opportunities for clients to consult with medical professionals, addressing any concerns they may have and reinforcing accountability. Through this program, the Scottsdale Weight Loss Center ensures that every client can transform their lives responsibly and sustainably while prioritizing their overall health and safety.
Program Five: Lifetime Wellness Education
The Scottsdale Weight Loss Center believes that weight loss is a lifelong journey, and thus the final program focuses on lifetime wellness education. This comprehensive initiative is dedicated to equipping clients with the knowledge and skills necessary to maintain their weight loss success beyond the initial program completion. Clients participate in ongoing workshops that cover a variety of topics, including meal planning, stress management, exercise adaptation, and mindful eating practices.
The goal of the lifetime wellness education program is to ensure that clients are not only taught how to lose weight but also how to maintain their newfound lifestyles. This program emphasizes the importance of establishing a balanced routine that includes regular physical activity, nutritious eating, and mental well-being practices. By integrating these aspects into their everyday lives, clients can develop sustainable works and long-term wellness.
Moreover, this program continually fosters community connections among clients past and present. Regular alumni check-ins and support groups serve to reinforce accountability and provide encouragement, creating a supportive network that lasts well beyond the weight loss journey. Clients often share personal success stories and strategies, creating an environment where everyone thrives together. By focusing on lifelong health, the Scottsdale Weight Loss Center aims to shape behaviors that lead to continuous growth and fulfillment in well-being.
Wrap-Up and Common Queries
The Scottsdale Weight Loss Center has carved a niche for itself by adopting a holistic and compassionate approach to weight loss. Their commitment to providing scientifically backed, individualized programs designed for lasting success ensures that clients can achieve significant transformations while prioritizing their overall health and wellness. It’s essential to understand that weight loss is not merely about numbers; it’s about embracing a lifestyle that supports physical, emotional, and psychological well-being.
Frequently, prospective clients ask how quickly they can expect to see results. It’s essential to recognize that every individual’s journey is unique, influenced by factors such as starting weight, adherence to the program, and intrinsic motivation. However, most clients begin to notice positive changes in their bodies and habits within weeks. The center encourages a focus on non-scale victories, such as increased energy levels and improved self-esteem, which serve as vital motivators along the journey.
Another common inquiry pertains to the sustainability of the weight loss achieved. The Scottsdale Weight Loss Center emphasizes that the skills and knowledge gained through their programs should be regarded as lifelong tools. Education on nutrition, fitness, and healthy lifestyle choices equips clients to navigate challenges beyond the program, ensuring that clients are prepared to face life’s ups and downs without reverting to unhealthy habits. Ultimately, success is defined as the ability to maintain weight loss and lead a healthier life, and the Scottsdale Weight Loss Center stands by its clients every step of the way.
In summary, the Scottsdale Weight Loss Center has established itself as a leader in the realm of weight loss transformations. By combining personalized programs, expert support, and a focus on lifelong wellness, the center empowers individuals to break free from cycles of unhealthy behavior. Those looking to undergo significant weight loss or enhance their wellness are encouraged to explore the offerings at the Scottsdale Weight Loss Center, where their journey towards health and happiness begins.
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