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Link for Idiosyncrasy Reaction video https://youtu.be/eN8ncQIT_OQ Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - https://play.google.com/store/apps/details?id=co.bolton.nqilv A ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective. The larger the therapeutic index (TI), the safer the drug is. If the TI is small (the difference between the two concentrations is very small), the drug must be dosed carefully and the person receiving the drug should be monitored closely for any signs of drug toxicity. If we plot a curve between plasma drug concentration and per cent of people then the desired effect in 50 per cent of people is called as- Effective dose in 50 % or ED50. and the dose of that particular drug which crosses the safety margin and starts to show side effect to serious lethal effect is called as LD50. LD50 is basically used for animals and for human beings it is termed as TD50 and toxic dose in 50 per cent of the population. so we can say that the therapeutic index is- TI= Does that produces toxicity in 50 per cent of people divided by the dose that produces an effective clinical response in 50 per cent of people. The therapeutic dose can also be stated as the distance between ED50 and LD50. a drug which has a value of therapeutic index more than 01 is considered as a safe and the drug having TI value less than 01 is considered as toxic. The example of high therapeutic index drugs are- penicillin, Diazepam and Atenolol Example of low therapeutic index drugs are- warfarin lithium digoxin phenytoin gentamicin amphotericin 5-fluorouracil zidovudine In short - Therapeutic index is an expression of the relative toxicity as compared to the efficacy of a given compound. In animal studies, it can be computed as the ratio of the median lethal dose (LD50) to the median effective dose (ED50). In humans, it is frequently expressed as the ratio of the median toxic dose (TD50) to the ED50. Get in touch with the solution by just clicking following links- Facebook Page- https://www.facebook.com/pharmavideo/ Facebook Group- https://www.facebook.com/groups/solutionpharamcy Instagram- https://www.instagram.com/solutionpharmacy/ Mail Us for Free Pharmacology Materials- [email protected] LinkedIn- http://linkedin.com/in/pushpendrakpatel

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Shahi Oil. Make Your Penis Size 100% Guaranteed. Tightness. While some individuals claim benefits from herbal penis oils, scientific evidence supporting their effectiveness is limited. It's crucial to be cautious about such products and consider consulting with a healthcare professional for personalized advice on any concerns you may have. Ayurveda, the traditional system of medicine in India, offers various remedies for kidney stones. It's important to note that these remedies should be used under the guidance of a qualified Ayurvedic practitioner, and their effectiveness may vary from person to person. Additionally, it's crucial to consult with a healthcare professional for a proper diagnosis and treatment plan. Here are some Ayurvedic remedies that are commonly suggested for kidney stones: 1. **Hydration:** Drink plenty of water throughout the day to help flush out toxins and prevent the formation of stones. Adequate hydration is crucial in preventing kidney stone formation. 2. **Dietary Changes:** - Limit intake of oxalate-rich foods such as beets, chocolate, nuts, tea, and spinach. - Reduce consumption of high-oxalate vegetables. - Avoid excessive intake of salt and animal proteins. 3. **Herbal Remedies:** - **Punarnava (Boerhavia diffusa):** Known for its diuretic properties, Punarnava is believed to help in reducing kidney stones and preventing their recurrence. - **Gokshura (Tribulus terrestris):** Acts as a natural diuretic and may help in kidney stone management. - **Varuna (Crataeva nurvala):** Traditionally used in Ayurveda for kidney and bladder disorders, Varuna is believed to have stone-dissolving properties. 4. **Ayurvedic Formulations:** - **Chandraprabha Vati:** This herbal formulation is commonly used to support kidney health and may aid in dissolving kidney stones. - **Punarnavadi Kwath:** A decoction made from Punarnava and other herbs, it is used for its diuretic and stone-dissolving properties. 5. **Lifestyle Recommendations:** - **Yoga and Pranayama:** Certain yoga postures and breathing exercises, such as Paschimottanasana and Bhujangasana, may help improve kidney function and promote overall well-being. - **Regular Exercise:** Engage in regular physical activity to maintain a healthy weight and promote kidney health. Remember that Ayurvedic remedies are holistic in nature and focus on balancing the body's doshas (Vata, Pitta, Kapha). Individualized approaches based on one's constitution and the specific imbalance are essential. It is crucial to consult with an experienced Ayurvedic practitioner to determine the most suitable remedies for your unique condition. Always seek professional medical advice before starting any new treatment, especially if you have pre-existing health conditions or are taking medications.

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