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If you found this video helpful and the advice I have given useful then feel free to press the like button and subscribe its free and is a great way of supporting the channel. Alternatively, if you would like to support this channel to help make new videos then feel free to donate via the super thanks button or via patreon: http://www.patreon.com/Drbretpalmer Patreon supporters will get access to my book as well as lecture notes and PowerPoint presentations. These presentations will show full pathology so you know what the lesions look like in real life. I can also do private consultations. Alternatively, you can get my book directly from https://www.amazon.co.uk/Live-Longer-Healthier-Happier-Life-ebook/dp/B08KYLG86V If you would like to direct message me, feel free to contact me via YouTube or via Instagram on https://www.instagram.com/drbretpalmer Please remember to get a full set of sexual health screening tests, partners will also need to be tested and if positive will need to be treated appropriately. Treatment should always be guided by your doctor. this is advice for education only and not a formal diagnosis of any problem you may currently have. This video is also not a substitute for a clinical consultation or as replacement advice. Please follow your doctors’ instructions and advice. Take care and have great sexual health Kind regards Dr Bret Palmer Legal Disclaimer The Explained Series contains content generated by Dr Bret Palmer. Content provided via YouTube is for general information purposes ONLY. Information videos are not produced to provide specific advice on which you should rely. Medical education videos on The Explained Series are not a substitute for professional medical care by a qualified doctor or other healthcare professional. You should ALWAYS consult with your doctor regarding any concerns about your condition or treatment and before taking, or not taking, any action based on the content produced by Dr Bret Palmer. Reasonable effort shall be made to update the information on The Explained Series YouTube channel. However, we make no representations, warranties, or guarantees, whether express or implied, that the content is accurate, complete or up-to-date. Dr Bret Palmer also does not warrant or represent that the information or materials available through The Explained Series YouTube channel will meet your particular requirements or needs. Dr.Bret Palmer is licensed and has a clinical practice in the United Kingdom. All information shared by Dr.Bret Palmer is for general information purposes only and is not to be used to treat, diagnose or self-diagnosis at any time. Dr.Bret Palmer’s use of the term doctor when referring to himself is simply referring to his degree and licensing. There is no doctor patient relationship between you and Dr.Bret Palmer. You should seek advice from your health care practitioner before changing anything in the way of your dietary, nutritional, washing or health management. You should always seek advice from your qualified health care physician regarding any health condition. Dr Bret Palmer, the Explained series or the NHS are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this video or site.

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An erection is the result of increased blood flow into the penis. During arousal, muscles in the penis relax, allowing for increased blood flow through the penile arteries. This blood fills two chambers inside the penis called the corpora cavernosa, causing the penis to go rigid. In erectile dysfunction, the penis cannot sustain an erection. There are numerous causes of erectile dysfunction, including cardiovascular disease, in which the arteries are too damaged to allow blood to properly flow into the penis. Other causes may include stress, anxiety, diabetes, and drug or alcohol use. For more awesome 3D anatomy resources, check out https://www.visiblebody.com.

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Download the "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Tests and other GPAT Materials - https://play.google.com/store/apps/details?id=co.bolton.nqilv Introduction to Drugs for Erectile Dysfunction: Erectile dysfunction (ED) is a condition characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. It can be caused by various factors, including physical, psychological, or a combination of both. Drugs for ED, also known as phosphodiesterase type 5 (PDE5) inhibitors, are a class of medications designed to improve blood flow to the penis, facilitating erections. Mechanism of Action: PDE5 inhibitors work by blocking the action of the enzyme phosphodiesterase type 5. This enzyme is responsible for breaking down cyclic guanosine monophosphate (cGMP), a chemical messenger that relaxes smooth muscle cells and increases blood flow to the penis during sexual stimulation. When PDE5 is inhibited, cGMP levels increase, leading to enhanced relaxation of smooth muscle cells in the erectile tissue and increased blood flow to the penis. This results in improved erectile function. Structure-Activity Relationship (SAR): The main drugs used for treating erectile dysfunction belong to the PDE5 inhibitor class. They include: Sildenafil (Viagra): Structure: Sildenafil's chemical structure consists of a pyrazolopyrimidinone core. SAR Highlights: The pyrazole ring is crucial for PDE5 inhibition. The substituents on the pyrazole ring affect the potency and selectivity of the drug. Modifications in the side chains can influence the drug's pharmacokinetics and duration of action. Tadalafil (Cialis): Structure: Tadalafil has a pyrazinopyridoindole core structure. SAR Highlights: The pyrazine and pyridine rings are essential for PDE5 inhibition. The substituents on the pyrazine ring can influence the drug's selectivity and potency. Tadalafil has a longer half-life compared to sildenafil, which allows for a longer duration of action. Vardenafil (Levitra): Structure: Vardenafil has a pyrazolopyrimidine core similar to sildenafil. SAR Highlights: The core structure is similar to sildenafil, but vardenafil has a different substituent pattern, affecting its pharmacological properties. Vardenafil exhibits enhanced selectivity for PDE5 compared to other PDE isoforms. Avanafil (Stendra): Structure: Avanafil has a unique pyrimidinone core. SAR Highlights: Avanafil's structure is distinct from the other PDE5 inhibitors, which contributes to its rapid onset of action and selectivity for PDE5. These drugs are generally well-tolerated, but they can interact with certain medications and have contraindications for individuals with specific medical conditions. It's crucial to consult a healthcare provider before starting any ED medication. Get in touch with the solution by just clicking the following links- Facebook Group- https://www.facebook.com/groups/solutionpharamcy Mobile App - https://play.google.com/store/apps/details?id=co.bolton.nqilv New Channel (Pharmacy Dictionary) https://www.youtube.com/channel/UCt6OXVV_2oxf5DD0Mad6e9A E-Mail for official and other work - [email protected] #solutionpharmacy #Pharmacologyclass #Pharmacognosyvideos #GPAT

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If you never had Mamajuana, the national drink of the Dominican Republic you are missing out. This mamajuana recipe is the only recipe you need for the best mamajuana recipe on youtube. Mamajuana has many health benefits too. It has been used to boost immunity, digestion, blood cleansing, sore throats, cold remedies and virus cures and is also known as the Dominican viagra as it is an aphrodisiac. (Let me know if it works men) .**** Please note this is a sipping drink or I like to mix with other drinks such as Teas and Carbonated drinks. This is how you make homemade Mamajuana with only 4 ingredients. Mamajuana is a must try for something unique and different. **MY AFFILIATE DISCLAIMER:** This post may contain affiliate links which means I may receive a commission for purchases made through links *********Direct Link to the Mamajuana Kits in our Amazon Store***** https://www.amazon.com/shop/howtodoneright/list/C71B0PH14G9Z?ref_=aipsflist ************OUR NEW AMAZON STORE******************** https://www.amazon.com/shop/howtodoneright ONE STOP SHOP for all our Wine Supplies and Much More ************************************************************ **************INSTAGRAM******************** https://www.instagram.com/howtodoneright *********************************************** Dominican Recipe 1 Mamajuana Kit 10% Honey 50% Rum 40% Red Wine HowToDoneRight Recipe 1 Mamajuana 10% Honey 30% Rum 60% Red Wine **************INSTAGRAM******************** https://www.instagram.com/howtodoneright *********************************************** *************MERCH IS HERE******************* HOWTODONERIGHT AND ALONGFORTHEJOURNEY MERCHANDISE GET IT NOW!!!!!!!!! https://alongforthejourney.myspreadshop.com/ *************************************************

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