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Oncotarget published this trending research paper on February 2, 2021, entitled, "Testosterone deficiency in men receiving immunotherapy for malignant melanoma" by researchers from the University of Iowa. Abstract: Immunotherapy has been established as a standard of care for patients with malignant melanoma, however, the long-term side-effects of immunotherapy are still emerging. Studies over the last decade have documented increasing reports of endocrine dysfunction following the initiation of immunotherapy. Our study aimed to detect the proportion of men who have low testosterone before, during, and or/after receiving immunotherapy for malignant melanoma, and to determine the proportion of men who receive testosterone replacement therapy after detection of low testosterone. We performed retrospective chart review of patients with malignant melanoma treated with immunotherapy. Low testosterone was identified in 34 out of 49 patients at some point during their treatment with immunotherapy. Despite low testosterone levels in two-thirds of patients, only three patients were treated with testosterone replacement therapy. In addition to laboratory evidence of low testosterone, patients were also symptomatic as 43 out of 49 patients reported fatigue to their providers. Four patients developed hypophysitis and subsequent hypopituitarism, all of whom were receiving Ipilimumab. We conclude that patients with stage 3 or 4 melanoma treated with immunotherapy appear to be at an increased risk of developing testosterone deficiency during their treatment. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27876 DOI - https://doi.org/10.18632/oncotarget.27876 Full text - https://www.oncotarget.com/article/27876/text/ Correspondence to - Madeline Peters - [email protected] Keywords - cancer, melanoma, immunotherapy, testosterone deficiency, androgens, skin cancer About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact [email protected] 18009220957
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Ed Sheeran live at Chill Pill on the 27th July 2010. Chill Pill began as a night curated by friends, hosting live talent without microphones in the basement of a nightclub in Shoreditch, London. Ed, a good friend of ours, kindly gave us his time to play one evening. Cheers Ed. Footage copyright of Kim-Leng Hills. All rights reserved.
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Harmony Leaf CBD Gummies are a popular and effective natural remedy for erectile dysfunction (ED) that has been gaining attention in recent years. Made from high-quality CBD extract, these gummies offer a safe and easy way to improve sexual performance and enhance libido without the need for prescription medications or invasive treatments.
For those who suffer from ED, the condition can have a significant impact on both their physical and emotional well-being. It can lead to feelings of inadequacy, embarrassment, and frustration, as well as strain relationships and overall quality of life. Fortunately, Harmony Leaf CBD Gummies offer a simple solution that can help alleviate these symptoms and improve overall sexual health.
In this detailed review, we will explore the benefits of Harmony Leaf CBD Gummies for ED, how they work, and why they are becoming a popular choice for many individuals seeking a natural and effective treatment for this common issue.
How Harmony Leaf CBD Gummies Work for ED:
Harmony Leaf CBD Gummies work by targeting the root causes of ED, including stress, anxiety, hormonal imbalances, and poor blood flow. CBD, the active ingredient in these gummies, has been shown to have a range of therapeutic effects that can help improve sexual function and performance.
One of the main ways that CBD helps with ED is by reducing stress and anxiety levels. Chronic stress and anxiety can have a negative impact on sexual performance by increasing cortisol levels and interfering with hormone production. CBD has been shown to reduce cortisol levels and promote a sense of calm and relaxation, which can help improve libido and sexual function.
In addition to reducing stress, CBD also has vasodilating effects, which means it can help improve blood flow to the penis. Poor blood flow is a common cause of ED, as it prevents the smooth muscles in the penis from relaxing and filling with blood. By promoting vasodilation, CBD can help enhance blood flow to the penis and improve erectile function.
Benefits of Harmony Leaf CBD Gummies for ED:
There are several key benefits of using Harmony Leaf CBD Gummies for ED, including their natural and non-invasive nature, their effectiveness in improving sexual function, and their lack of side effects. Unlike prescription medications, which can come with a range of unwanted side effects, CBD gummies are a safe and gentle alternative that can be used without any concerns about adverse reactions.
Another benefit of Harmony Leaf CBD Gummies is their ease of use and convenience. Simply pop a gummy in your mouth and enjoy the delicious taste while experiencing the therapeutic effects of CBD. No need to worry about taking multiple pills or following a strict regimen – these gummies can be incorporated into your daily routine with ease.
Furthermore, Harmony Leaf CBD Gummies are also cost-effective compared to other treatments for ED. Prescription medications can be expensive and may not be covered by insurance, making them inaccessible for many individuals. CBD gummies offer a more affordable option that can provide significant benefits without breaking the bank.
How to Use Harmony Leaf CBD Gummies for ED:
Using Harmony Leaf CBD Gummies for ED is simple and straightforward. Begin by determining the appropriate dosage for your needs – this may vary depending on the severity of your symptoms and your individual response to CBD. Start with a low dose and gradually increase until you find the optimal level that works for you.
Take one gummy as needed, preferably on an empty stomach for faster absorption. Allow the gummy to dissolve in your mouth before swallowing to maximize the effects of the CBD. You can take additional gummies throughout the day as needed, but be sure not to exceed the recommended dosage to avoid any potential side effects.
It is important to note that while Harmony Leaf CBD Gummies are generally well-tolerated, some individuals may experience mild side effects such as dry mouth, fatigue, or changes in appetite. If you experience any adverse reactions, discontinue use and consult with a healthcare provider for further guidance.
Frequently Asked Questions About Harmony Leaf CBD Gummies for ED:
1. Are Harmony Leaf CBD Gummies legal?
Yes, Harmony Leaf CBD Gummies are made from hemp-derived CBD and contain less than 0.3% THC, making them legal in most states. However, it is always best to check your local laws and regulations regarding CBD products before purchasing.
2. How long do Harmony Leaf CBD Gummies take to work?
The effects of Harmony Leaf CBD Gummies can vary from person to person, but many individuals report feeling the benefits within 30 minutes to an hour after taking a gummy. Results may be enhanced with regular and consistent use over time.
3. Can Harmony Leaf CBD Gummies be used in conjunction with other medications?
It is always recommended to consult with a healthcare provider before using CBD products, especially if you are taking other medications. CBD may interact with certain medications, so it is important to ensure that there are no potential drug interactions that could affect your health.
4. Are there any side effects of using Harmony Leaf CBD Gummies for ED?
While Harmony Leaf CBD Gummies are generally well-tolerated, some individuals may experience mild side effects such as dry mouth, fatigue, or changes in appetite. These side effects are typically temporary and should subside with continued use.
5. Can Harmony Leaf CBD Gummies help with other sexual health issues?
Yes, Harmony Leaf CBD Gummies can help with a range of sexual health issues beyond ED, including low libido, performance anxiety, and overall sexual wellness. CBD’s therapeutic effects on stress, anxiety, and blood flow can contribute to improved sexual function and satisfaction.
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In recent years, there has been growing interest in using CBD gummies for various health benefits, including treating erectile dysfunction (ED). One brand that has gained popularity for its CBD gummies is Penguin CBD. These gummies are infused with high-quality CBD and claim to offer a natural solution for ED without the side effects commonly associated with traditional medications. Many users have reported positive results after using Penguin CBD gummies for their ED, leading to a surge in demand for this product.
User Feedback on Penguin CBD Gummies for ED Treatment
One user, John, shared his experience with using Penguin CBD gummies to help with his ED. He had been struggling with this issue for years and had tried various medications with little success. After hearing about the potential benefits of CBD for ED, he decided to give Penguin CBD gummies a try. To his surprise, he noticed a significant improvement in his symptoms after just a few weeks of consistent use. John reported that his overall experience with Penguin CBD gummies was extremely positive, and he would recommend them to anyone dealing with similar issues.
Another user, Sarah, also found relief from her ED symptoms by using Penguin CBD gummies. She had been hesitant to try CBD products at first but decided to give them a chance after hearing about their potential benefits. Sarah was pleasantly surprised by how effective the gummies were in helping her overcome her ED. She noted that not only did her symptoms improve, but she also experienced a sense of overall well-being and relaxation. Sarah now incorporates Penguin CBD gummies into her daily routine and has seen lasting benefits.
Benefits of Using Penguin CBD Gummies for ED
One of the main reasons why users turn to Penguin CBD gummies for ED treatment is the natural and holistic approach they offer. Unlike traditional medications that often come with a host of side effects, CBD gummies are derived from the hemp plant and offer a more gentle and sustainable solution. Users like that they can experience relief from ED symptoms without the fear of negative repercussions on their overall health.
Additionally, Penguin CBD gummies are easy to incorporate into daily life and provide a convenient way to manage ED symptoms. The gummies come in pre-dosed servings, making it simple for users to track their CBD intake and adjust as needed. This level of convenience is especially beneficial for those with busy lifestyles who may struggle to adhere to a strict medication regimen.
Another advantage of using Penguin CBD gummies for ED is the potential for long-lasting results. Many users report that they experience not only immediate relief from symptoms but also sustained benefits over time. This can be attributed to the natural properties of CBD, which work with the body’s endocannabinoid system to promote balance and overall wellness. By incorporating CBD gummies into their daily routine, users may find that they experience ongoing improvements in their ED symptoms.
Conclusion
In conclusion, the user feedback on Penguin CBD gummies for ED treatment is overwhelmingly positive. Many individuals have found relief from their symptoms and have experienced a range of other benefits, such as improved overall well-being and a sense of relaxation. The natural approach of CBD gummies, coupled with their convenience and potential for long-lasting results, makes them a promising option for those seeking an alternative solution for ED. If you are dealing with ED and are considering trying CBD gummies, Penguin CBD gummies may be worth exploring based on the positive reports from users.
Have additional questions about using Penguin CBD gummies for ED treatment? Check out our FAQ section below for more information.

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When it comes to male enhancement supplements, Rhino sex pills have gained popularity in recent years. These pills claim to enhance sexual performance, increase stamina, and improve overall sexual health. But with so many options available in the market, it can be challenging to determine which one is right for you. In this in-depth review, we will take a closer look at Rhino sex pills to help you make an informed decision before trying them out.
Ingredients
Rhino sex pills are known for containing a blend of natural ingredients that are believed to improve sexual performance. Some common ingredients found in these pills include L-arginine, Korean red ginseng, horny goat weed, and maca root. These ingredients are said to help increase blood flow to the penis, boost libido, and enhance stamina. However, it is essential to consult with a healthcare provider before taking any supplements to ensure they are safe for you.
Effectiveness
While some men swear by the effectiveness of Rhino sex pills, others have reported mixed results. Some users have claimed to experience improved erections, increased libido, and better stamina after taking these pills regularly. However, it is essential to note that results may vary from person to person. It is crucial to manage expectations and understand that no supplement can guarantee instant results.
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Side Effects
Like any other supplement, Rhino sex pills may come with potential side effects. Some users have reported experiencing headaches, nausea, dizziness, and digestive issues after taking these pills. It is vital to be aware of any possible side effects and discontinue use if you experience any adverse reactions. Additionally, it is crucial to follow the recommended dosage instructions to minimize the risk of side effects.
Cost
Rhino sex pills are often sold at a relatively affordable price compared to other male enhancement supplements on the market. However, it is essential to consider the cost-effectiveness of these pills in the long run. Some users may find that consistently purchasing these pills can add up over time. It is essential to evaluate your budget and determine if investing in Rhino sex pills is the right choice for you.
Availability
Rhino sex pills are widely available online and in select stores. While the convenience of purchasing these pills online may appeal to some users, it is crucial to ensure you are buying them from a reputable source. It is essential to research the product, read reviews, and verify the authenticity of the pills before making a purchase.
Overall, Rhino sex pills offer a natural alternative for men looking to enhance their sexual performance. However, it is essential to approach these supplements with caution and consult with a healthcare provider before trying them out. Remember that results may vary, and it is crucial to manage expectations when using male enhancement supplements. If you have any concerns about taking Rhino sex pills, do not hesitate to seek professional advice. Ultimately, making an informed decision about using these pills can help you achieve the desired results while maintaining your overall health and well-being.
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