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New evidence brings more good news about the unanticipated effects of the GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt -- TRANSCRIPT -- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. It’s quite a thing that we live in an era with the biggest blockbuster weight-loss drugs in history, and I can look at you straight-faced and say, yeah, but honestly that’s not the most interesting thing about the GLP-1 receptor agonists such as Ozempic. Beyond their clear utility in weight loss, we have good data that demonstrate the drugs lead to improvements in rates of heart disease, liver disease, and even all-cause mortality, and intriguing reports of strange off-target effects: a reduction in gambling, drinking, drug use, smoking, and compulsive shopping. It’s honestly hard to find an organ system or self-destructive behavior that GLP-1 drugs don’t seem to improve somehow. It’s almost strange. It’s as if the statins came out and everyone was excited about the cholesterol going down, and then we discovered that they reversed hair loss or took three strokes off your golf game. How does one drug do so many things? I think the behavioral changes are the clue. The fact that people may drink or smoke less on these drugs should tell you that something is happening in their brains. And if these drugs are acting on the brain, you might well wonder if they can reduce the risk for brain disease — dementia. And, at least according to a new study, the answer appears to be yes. As the GLP-1 drugs started getting more and more popular, I decided to perform some due diligence and refresh what I had learned in med school about this thing called “glucagon-like peptide.” These drugs bind to the same receptor that GLP does, primarily to cause the pancreas to release more insulin when blood sugar is high. But we have plenty of drugs that stimulate insulin release. And they don’t seem to have all these other weird effects. So, what’s going on? When a drug acts on a specific receptor, it is worth seeing what cells in the body have that receptor, and this is a pretty interesting figure that shows that. You see high expression in the pancreas — no surprise. But next is expression in the heart muscle — interesting, considering these drugs have been shown to reduce the risk for heart disease. Then the salivary glands, and then… the cerebral cortex. The brain. And not just any part of the brain, the thinking part of the brain. A lot happens when these drugs bind to a receptor on a cell. But the brain is a mysterious and important organ. In contrast, the heart is relatively simple, and there are multiple randomized trials that show that GLP-1 drugs, as well as some other drugs for diabetes, such as the SGLT2 inhibitors, pioglitazone, and metformin, reduce the risk for cardiovascular disease in people with diabetes. So, it makes sense to ask whether these drugs would do the same for brain disease. Enter this study, "Cardioprotective Glucose-Lowering Agents and Dementia Risk," from Catriona Reddin and colleagues in JAMA Neurology. It’s an impressive bit of work combining data from 23 different randomized trials of these drugs including more than 150,000 individual people, to determine whether they reduce the risk for dementia. This is the best evidence we have to date for a neuroprotective effect of GLP-1 inhibitors. And this is the only type of study that could give us this evidence. The reason you need to combine so much data to detect a signal is that, to date, no randomized trials of GLP-1 drugs have been designed with dementia as a primary outcome. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt
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Exipure is a potent all-natural formula for people’s weight loss. The great discovery of the Exipure formula has brought about a new scenario for those who wish to lose weight naturally. The brown adipose tissue (BAT) levels are the real cause of weight gain.
When taken properly, Exipure can bring great benefits, accelerating your metabolism and making internal cells work faster to lose weight. Exipure is such a success that has the most money back guarantee period, 180-days. You can only get exipure from the official website, then you will be safe!
How to use Exipure? You need to take only 1 capsule of Exipure daily with a big glass of water and the supplement will burn calories from your whole body, including more resistant areas.
Exipure was formulated with a blend of eight exotic natural ingredients, a powerful weight loss supplement that is being recommended by all professionals and experts.
Exipure is a weight loss supplement that works differently than other weight loss supplements on the market today because they have the ability to increase brown fat levels in their nutritional makeup. The exotic ingredients in the composition of Exipure acts on the root cause of belly fat and increases brown tissue levels.
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The exipure supplement is FDA approved and GMP certified facility. All the eight exotic ingredients are safe and will eliminate fat from the whole body.
Exipure is free of side effects, according to the manufacturer you have to do the treatment for at least 3 to 6 months.
Unlike other weight loss supplements, using exipure over a period of months will give you long-term, consistent results. Fat elimination, faster metabolism and increased energy gains are some of the great benefits that the Exipure supplement can provide.
Exipure weight loss supplement is exclusively sold on the official website, anywhere else.
As I said in this Exipure review, everyone's body works differently and there is no guarantee that anyone will lose weight quickly without exercising. However, there are some factors that can lead to faster weight loss, and controlling BAT levels is one of them. There is no magic product that will solve your "how to lose weight fast without exercising" question, but there are certainly weight loss supplements and diet pills that can speed up your weight loss process. Exipure is one of those weight loss supplements that, combined with better habits like exercise and healthy eating, will give you amazing results.
According to the official website, exipure review was developed from Perilla leaf extract, Propolis, white korean ginseng, kudzu root, amur cork bark, holy basil, oleuropein, and quercetin . All ingredients were minimally researched and developed through a powerful blend of these nutrients, which together are able to accelerate 300 times more fat burning through brown adipose tissue levels (BAT).
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Have you heard about the Keto Diet episode on Shark Tank? If you’re curious about what happened and the key takeaways from that particular episode, you’ve come to the right place. The Keto Diet has been gaining popularity in recent years for its potential health benefits and weight loss effects. Let’s delve into the details of the Shark Tank episode featuring the Keto Diet and uncover the key insights that emerged from that encounter.
The Pitch
The entrepreneurs behind the Keto Diet product appeared on Shark Tank to seek investment and support for their business. They presented their line of keto-friendly snacks and meal replacements, highlighting the benefits of following a ketogenic diet for weight loss and overall health. The Sharks were intrigued by the growing trend of keto diets and the potential market for such products.
However, the entrepreneurs faced tough questions from the Sharks about the effectiveness of their products and the science behind the keto diet. They had to defend their claims and prove that their products were not just a fad but had real benefits for consumers who were looking to improve their health and lose weight.
Despite some skepticism from the Sharks, the entrepreneurs managed to make a compelling case for their Keto Diet products. They showcased customer testimonials and success stories, demonstrating the positive impact their products had on people’s lives. The Sharks were impressed by the passionate commitment of the entrepreneurs to promoting a healthy lifestyle through their keto-friendly offerings.
The Negotiation
As the pitch progressed, the Sharks became more interested in the business potential of the Keto Diet products. They started to discuss potential partnerships and investment opportunities with the entrepreneurs, exploring different ways to collaborate and expand the reach of the keto-friendly snacks and meal replacements.
There were negotiations around the valuation of the company and the terms of the investment deal. The Sharks were looking for a solid business strategy and a clear roadmap for growth from the entrepreneurs. They wanted to ensure that any investment made in the Keto Diet products would be a wise decision that would yield returns in the long run.
After some back and forth, a deal was struck between the entrepreneurs and one of the Sharks. The terms of the agreement were sealed, and the Keto Diet products gained a new ally in the business world. The entrepreneurs were thrilled to have the support and expertise of a seasoned investor to help them take their company to the next level.
The Aftermath
Following the Shark Tank episode, the Keto Diet products experienced a surge in popularity as consumers became more aware of the brand and its offerings. The endorsement from the Sharks gave the products a stamp of approval, leading to increased sales and recognition in the market.
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The entrepreneurs used the momentum from their appearance on Shark Tank to launch new products and expand their distribution channels. They leveraged the exposure gained from the show to drive growth and build a loyal customer base of keto enthusiasts who were eager to try their innovative snacks and meal replacements.
Overall, the Keto Diet episode on Shark Tank was a success story for the entrepreneurs behind the brand. It showcased the power of a compelling pitch and a strong business idea to attract investment and support from seasoned investors. The key takeaways from the episode highlighted the importance of passion, perseverance, and a clear vision for success in the competitive world of entrepreneurship.
Are you still curious about the Keto Diet Shark Tank episode or have any questions about the key takeaways? Check out the summary below for more insights and frequently asked questions about this exciting entrepreneurial journey.
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