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In this episode of "In the Interim..." we revisit the ground-breaking seamless phase 2/3 clinical trial for the GLP-1 agonist, dulaglutide—better known as Trulicity. We discuss the intricacies of the adaptive trial design, and the unique features that helped expedite development by 12-18 months. Listeners will gain insight into how Bayesian algorithms and innovative statistical methods were pivotal in navigating a complex trial design, benefiting Eli Lilly's pipeline and changing the landscape of diabetes treatment. Key Highlights: —Outline of the trial design and the barriers faced during its inception in 2007-2008. —Explanation of the Clinical Utility Index and its role in adaptive randomization. —The DSMB's role and interaction with Bayesian decision-making models. —Simulation-based design to optimize development efficiencies. —Insights into the predictive power of the trial on weight loss outcomes in subsequent trials. Quotes: —"The trial was run entirely by Bayesian algorithms." – Scott Berry —"They believed this utility function was absolutely the right way to go forward." – Scott Berry For more head to berryconsultants.com.

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What Supplements Can Help Increase GABA On Keto? In this video, we’ll discuss how to support your brain health while following a ketogenic diet. One important aspect of brain function is gamma-aminobutyric acid, or GABA, which plays a role in calming the mind and reducing feelings of anxiety and stress. While the ketogenic diet can naturally enhance GABA levels by aiding the conversion of another neurotransmitter, glutamate, certain supplements can further assist this process. We’ll cover key supplements that may help increase GABA levels, including Vitamin B6, Magnesium, Valerian root, and Passionflower. Each of these has unique properties that can potentially support GABA activity in the brain. We’ll also touch on the option of GABA supplements and the considerations that come with them. Timing your supplementation can be important, especially when it comes to improving sleep quality. Before making any changes to your supplement routine, it’s always a good idea to consult with a healthcare provider to ensure safety and appropriateness for your personal health needs. Join us as we explore these options and how they may fit into your ketogenic lifestyle. Don’t forget to subscribe to our channel for more helpful tips and information on the keto diet! ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@KetoKitchenHQ/?sub_confirmation=1 #KetoDiet #BrainHealth #GABA #VitaminB6 #Magnesium #ValerianRoot #Passionflower #KetoSupplements #AnxietyRelief #StressReduction #HealthyLifestyle #KetogenicLiving #MentalWellness #SleepQuality #SupplementGuide About Us: Welcome to Keto Kitchen HQ, your go-to channel for everything related to the keto diet. Whether you're a beginner looking to understand Keto Diet Basics or an experienced practitioner refining your approach, we cover a range of topics including Low-Carb Meal Planning, Ketosis Explained, and Keto-Friendly Foods. Our engaging videos will help guide you on your journey with insights into Intermittent Fasting, Keto for Weight Loss, and delicious Ketogenic Recipes.

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Many people worry whether using protein powder accelerates kidney damage, hair loss and acne. Here's a look at what the science tells us about these questions: 00:00 Intro 00:30 Kidney Damage People who already have kidney disease are often advised to follow a low protein diet. This is because eating protein can increase the filtration rate, and therefore put extra pressure on the kidney. In the long term, there is some research that suggests that a high protein diet may make kidney damage worse in people who already have kidney disease. But just because something is true in people who already have kidney disease, doesn't mean that it also applied to people who are healthy. Healthy kidneys have an incredible ability to adapt. We know that people can live with one kidney because a healthy kidney is easily able to adapt to a higher workload without any consequence. A recent study specifically that looked at the impact of a high protein diet in healthy people, found no negative effect of a high protein diet on kidney function: 02:10 Hair Loss Hair loss in men occurs because of a combination of genetics and the effect of testosterone. In men, testosterone is converted into DHT in the hair follicles. In men who are genetically at risk, testosterone converts large hair follicles into to small hair follicles that produce thin hair. I couldn't find any direct research into protein intake and hair loss. So to answer the question, I looked for indirect evidence that would link protein and hair loss. Since testosterone is a major driving factor for hair loss, if a high protein diet increases testosterone levels, that could link protein intake and hair loss. A couple of small studies suggest that protein intake doesn't increase testosterone levels, so as far as the research goes, it is unlikely that protein powder causes hair loss. 03:41 Acne Acne occurs due to a combination of genetics, normal skin bacteria, immune function and sensitivity to hormones. Sebaceous glands in the skin produce an oily substance called sebum, that normally lubricates the skin. In people who have acne, excess sebum clogs up skin pores and leads to inflammation. Hormones such as testosterone, DHT and Insulin-like Growth Factor (IGF) all increase the activity of sebaceous glands, and could therefore make acne worse. As I mentioned earlier, protein intake probably doesn't increase testosterone levels. There is some low quality evidence that dairy products may increase IGF levels and therefore accelerate acne in those people who are at risk. To further support this claim, there are case reports that whey protein made acne worse in a handful of patients. So it is possible that whey protein may make acne worse. A possible remedy for this is to use soy or plant based protein if you have severe acne. #protein #fitness #docunlock Full transcript: https://www.docunlock.org/youtube/is-protein-powder-bad-for-you All DocUnlock content is for educational purposes only and is not intended as a substitute for medical advice, diagnosis and treatment. Please read our Disclaimer: https://www.docunlock.org/medical-information-disclaimer -- References and Further reading: Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236074/ History of dietary protein and Kidney Damage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262767/ Guyton and Hall Textbook of Medical Physiology 12ed (p321) Androgens and Alopecia: https://www.ncbi.nlm.nih.gov/pubmed?term=12573818 Dietary protein intake and testosterone 1: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129168/ Dietary protein intake and testosterone 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778704/ Prevalence of acne: https://www.ncbi.nlm.nih.gov/pubmed?term=17945383 IGF and Pathogenesis of acne: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318522/ IGF-1, DHT and Acne: https://www.ncbi.nlm.nih.gov/pubmed/15781674 Case reports: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350548/ Case reports: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900340/ -- Video credits: Certain illustrations adapted from https://www.svgrepo.com/ and https://www.freepik.com/ (macrovector / Freepik) Music: Motionarray (affiliate link): https://motionarray.com?ref=ankitgupta1 KSMK - First Love. Music promoted by Vlog No Copyright Music. Video Link: https://youtu.be/MxN26gVqG_Q -- DocUnlock is a new YouTube channel with one purpose: to help people make better decisions about their own health, and the health of their families. SUBSCRIBE to our channel to stay in the loop! Follow us: https://www.facebook.com/DocUnlocked/ https://twitter.com/DocUnlocked Sign up to the DocUnlock Insider mailing list to receive updates direct to your inbox: https://www.docunlock.org/home/#docunlockinsider Website: https://www.docunlock.org/

Keto Gummies Kelly Clarkson Understanding Their Role In Her Weight Loss Journey

In episode 32 of The Functional Code, Dr. Addy and Dr. Jace delve into GLP-1 agonists like semaglutide and terzepatide, exploring their roles in weight loss and diabetes management. They discuss the mounting reliance on these medications, citing real-life examples and addressing societal and cultural impacts on health. The podcast also covers the historical adjustments to hypertension markers, the projected rise in obesity and diabetes by 2050, pharmaceutical influences, and strategies for utilizing GLP-1 agonists effectively. Listeners are encouraged to take a proactive role in their health, with insights into potential side effects, complementary strategies like resistance training and adequate protein intake, and the importance of building healthy habits. Dr. Jace Nybo D.C. Dr. Addy Knutson D.C. Guide: 00:00 The Hunger Zombie Incident Intro 01:08 Welcome to the Functional Code 01:37 Introduction to GLP-1 and Weight Loss 03:33 The Obesity Epidemic 06:34 Pharmaceutical Influence and Misleading Practices 09:07 Childhood Obesity and Long-Term Health Risks 17:34 Traditional and Surgical Interventions for Obesity 21:06 The History of Diabetes and Weight Loss Medications 28:31 Understanding GLP-1 Mechanisms 36:11 The Impact of GLP-1 on Health 39:30 Misguided Medical Advice and Patient Preparation 40:42 The Hunger Zombie Phenomenon 41:28 Advancements in Weight Loss Medications 44:07 Long-Term Use and Side Effects 59:27 The Importance of Resistance Training and Protein Intake 01:02:44 Proper Management and Use of Weight Loss Medications 01:06:47 Future Developments and Final Thoughts 01:11:54 Conclusion and Final Remarks Resources: doi.org/10.1136/bmj-2023-078225 doi.org/10.1186/s12933-023-01765-z doi.org/10.1016j.molmet.2020.101102 Instagram: instagram.com/thefunctionalcode/ TicTock: @thefunctionalcode Apple Podcast: podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557

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Discover the best techniques for measuring body fat loss effectively. We share tips for consistent measuring, the importance of scale tracking, and how to interpret your results for better progress. Start monitoring and achieving your fitness goals today! #BodyMeasurements #FatLossJourney #FitnessTracking #HealthGoals #BodyComposition #ScaleTracking #WeightLossTips #FitnessJourney #HealthyLifestyle #MeasureYourProgress

Nicola Coughlans 28 Pound Weight Loss How She Transformed Her Mind And Body

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Are you looking for a way to jumpstart your weight loss journey? With so many weight loss pills on the market, it can be overwhelming to decide which one is right for you. In this comprehensive analysis, we will review some of the most popular weight loss pills to help you make an informed decision. Our goal is to provide you with all the information you need to choose the best weight loss pill for your specific needs.

Product A: SlimFast

SlimFast is a popular weight loss pill that claims to help you lose weight quickly and easily. The main active ingredient in SlimFast is caffeine, which is known to boost metabolism and suppress appetite. However, many users have reported experiencing side effects such as jitters, headaches, and insomnia. It is important to consult with your doctor before taking SlimFast to ensure it is safe for you.

Overall, SlimFast can be effective for some individuals, but it may not be suitable for everyone. It is important to weigh the potential benefits against the possible side effects before deciding to try SlimFast.

If you are looking for a weight loss pill that is backed by scientific research and has minimal side effects, you may want to consider exploring other options.

Product B: Hydroxycut

Hydroxycut is another popular weight loss pill that has been on the market for many years. The main active ingredient in Hydroxycut is green tea extract, which is believed to increase metabolism and promote fat burning. However, some users have reported experiencing stomach upset and other digestive issues while taking Hydroxycut.

While Hydroxycut may be effective for some individuals, it is important to be cautious when taking this weight loss pill. It is always recommended to consult with a healthcare professional before starting any new weight loss supplement.

If you are looking for a weight loss pill that is natural and has minimal side effects, you may want to consider other options that do not contain stimulants like Hydroxycut.

Product C: Garcinia Cambogia

Garcinia Cambogia is a tropical fruit that is popular for its weight loss benefits. The active ingredient in Garcinia Cambogia is hydroxycitric acid (HCA), which is believed to inhibit fat production and suppress appetite. Many users have reported positive results with Garcinia Cambogia, such as decreased cravings and increased weight loss.

However, it is important to note that the effectiveness of Garcinia Cambogia varies from person to person. Some individuals may not see the same results as others, so it is important to set realistic expectations when taking this weight loss pill.

If you are looking for a natural weight loss pill that may help you lose weight and curb your appetite, Garcinia Cambogia could be a good option to consider. Be sure to consult with your doctor before starting any new weight loss supplement.

Product D: Alli

Alli is a weight loss pill that is available over the counter. The main active ingredient in Alli is orlistat, which works by blocking the absorption of fat in the intestines. While Alli can be effective for some individuals, it is important to follow a low-fat diet when taking this weight loss pill to prevent gastrointestinal side effects.

Many users have reported experiencing oily stools, gas, and other digestive issues while taking Alli. It is crucial to consult with your doctor before starting Alli to determine if it is the right weight loss pill for you.

If you are looking for a weight loss pill that works by blocking fat absorption, Alli may be a good option to consider. However, it is important to be aware of the potential side effects and follow a healthy diet and exercise regimen while taking Alli.

Product E: Phentermine

Phentermine is a prescription weight loss pill that is commonly prescribed to individuals who are obese or overweight with weight-related health problems. Phentermine works by suppressing appetite and increasing energy levels, which can help promote weight loss. However, Phentermine can be habit-forming and may cause side effects such as dry mouth, constipation, and insomnia.

While Phentermine can be effective for some individuals, it is crucial to follow your doctor’s recommendations and take the medication as prescribed. It is not recommended to take Phentermine for extended periods due to the potential for dependency and side effects.

If you are considering taking Phentermine for weight loss, be sure to discuss the potential risks and benefits with your healthcare provider. Phentermine may be a good option for individuals who have struggled to lose weight through diet and exercise alone.

Overall, when choosing a weight loss pill, it is essential to consider your individual needs, preferences, and medical history. Consulting with a healthcare provider before starting any new weight loss supplement is crucial to ensure it is safe and effective for you. By exploring different options and weighing the potential benefits against the possible side effects, you can make an informed decision about which weight loss pill is right for you.