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Get My Book On Amazon: https://a.co/d/avbaV48 Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/ Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/ 👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/start-here 1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/ Book A Call With Me: https://hunterwilliamscall.carrd.co/ Supplement Sources: https://hunterwilliamssupplements.carrd.co/ Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY Socials: Instagram: https://www.instagram.com/hunterwilliamscoaching/ Podcast: https://hunterwilliamspodcast.buzzsprout.com/ Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/ In this video, I dive deep into the reasons behind the infamous “GLP plateau”—that frustrating point where fat loss on GLP-1 peptides like semaglutide, tirzepatide, and retatrutide comes to a grinding halt. I break down the physiological, hormonal, and lifestyle factors that drive plateaus, plus practical, science-backed solutions to get results moving again. If you’re struggling with stalled progress, this is the most comprehensive breakdown you’ll find on how to identify, understand, and push through GLP plateaus. Let’s break it all down step by step: ⸻ Timestamps 0:00 – Introduction: Why Do GLP-1 Plateaus Happen? 0:35 – Why Weight Loss Plateaus Are Universal 1:22 – How GLP-1s Work (Mechanisms: Semaglutide, Tirzepatide, Retatrutide) 2:36 – Typical Weight Loss Trajectory on GLP-1s 3:18 – When (and Why) Most People Plateau 4:55 – Plateau ≠ Failure: The New Weight Set Point 5:39 – Physiological & Metabolic Causes of Plateaus 6:26 – Resting Metabolic Rate Drop & Adaptive Thermogenesis 7:31 – Decreased Thermogenesis, Exercise Efficiency, & Mitochondria 8:42 – Muscle Loss and Its Impact on Plateaus 9:44 – NEAT (Non-Exercise Activity Thermogenesis) Drops 10:18 – Why the Body Adapts: Our Ancestral Survival Mechanism 11:06 – Hormonal Adaptations: Leptin, Ghrelin, Insulin 13:03 – Leptin Drop: Increased Hunger, Lower Metabolism 13:41 – Ghrelin Rise: Appetite Returns 15:17 – Insulin, Metabolic Health & Fat Loss 17:20 – Thyroid Hormones: T3, Metabolic Rate, and the Plateau 19:03 – Cortisol, Stress, and Fat Storage 20:07 – Sex Hormones: Testosterone, Fat Loss, and Plateaus 21:46 – Amylin, Neuropeptide Y, and Brain Pathways 22:44 – Behavioral & Lifestyle Factors: NEAT, Adherence, Calorie Creep 24:44 – Psychological Fatigue, Sleep, Diet Quality, & Hydration 28:27 – Is It a True Plateau? Body Fat vs. Weight Loss 28:32 – Pharmacological Tolerance & Dosing Issues 30:00 – Appetite Pathways and Receptor Desensitization 31:52 – Dose Ceiling: When More Isn’t Always Better 33:26 – Strategies to Break Through a Plateau 34:16 – Re-evaluating Diet: Macros, Sugar Diet, and Tracking 34:45 – Activity, Resistance Training, and NEAT 35:03 – Sleep, Stress, Thyroid, and Other Medications 35:44 – Add-On Pharmacology: LDN, Cagrilintide, Leptin Analogs 37:01 – Mitochondrial Pathways: BAM15, SLU-PP-332, Carnitine 37:50 – Cycling, Refeeds, and Metabolic Resensitization 39:55 – Fasting, Intermittent Fasting, and Nutrition 40:08 – Recap: Everyone Plateaus—How Will You Respond? 41:02 – Thank You & Outro

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