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In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity." We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways. First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose. Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings. #HubermanLab #Science Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman Levels: https://levels.link/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Dr. Peter Attia Website: https://peterattiamd.com Outlive: The Science & Art of Longevity: https://peterattiamd.com/outlive The Peter Attia Drive Podcast: https://peterattiamd.com/podcast Newsletter: https://peterattiamd.com/newsletter X (formerly Twitter): https://twitter.com/PeterAttiaMD Instagram: https://www.instagram.com/peterattiamd YouTube: https://www.youtube.com/c/PeterAttiaMD Facebook: https://www.facebook.com/peterattiamd Articles Reassessing the evidence of a survival advantage in Type 2 diabetes treated with metformin compared with controls without diabetes: a retrospective cohort study: https://bit.ly/3EypTAJ The Hallmarks of Aging: https://bit.ly/3ZeqnFI Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls: https://bit.ly/3Lespjp A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers: https://bit.ly/3LiAaEX Other Resources TAME (Targeting Aging with Metformin) Trial: https://bit.ly/3P7eMDI Interventions Testing Program (ITP): https://bit.ly/3EDtmOg Slow-Carb Diet (Tim Ferris): https://bit.ly/462q6YD Dr. Alia Crum: Science of Mindsets for Health & Performance (Huberman Lab episode): https://bit.ly/3PdbKhd Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping (Huberman Lab episode): https://bit.ly/3PkGopc Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects (Huberman Lab episode): https://bit.ly/3Pg7jT3 Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction (Dead salmon study): https://bit.ly/3PvJvf9 Timestamps 00:00:00 Dr. Peter Attia, Journal Club 00:03:27 Sponsors: Helix Sleep & Levels 00:06:11 Dreams 00:12:36 Article #1, Metformin, Mitochondria, Blood Glucose 00:19:47 Type 2 Diabetes & Causes, Insulin Resistance 00:25:30 Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study 00:36:19 Sponsor: AG1 00:37:15 TAME Trial; Demographics, Twin Cohort 00:44:27 Metformin & Mortality Rate 00:51:28 Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power 01:01:17 Sponsor: InsideTracker 01:02:23 Hazard Ratios, Censoring 01:09:00 Metformin Advantage?, Variables, Interventions Testing Program 01:16:02 Berberine, Acarbose, SGLT2 Inhibitors 01:23:48 Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers 01:32:22 Tool: Reading Journal Articles, 4 Questions, Supplemental Information 01:38:10 Article #2, Belief Effects vs. Placebo Effect 01:45:22 Nicotine Effects 01:51:07 Nicotine Doses & Belief Effects, fMRI Scan 02:00:07 Biological Effects, Dose-Dependent Response & Belief Effects 02:05:14 Biology & Beliefs, Significance, Dopamine Response, Non-Smokers 02:10:57 Dose-Dependence & Beliefs, Side Effects, Nocebo Effect 02:19:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer

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Learn through this video about yet another new approach to manage type 2 diabetes. What are GLP-1 or glucagon-like peptide receptor agonists? They are essentially incretin mimetics. And, what are their cardiovascular enhancing benefits in controlling diabetes. Dr. Sharad Jaitly further explains in this video. Insight: Management of diabetes type 2 has new novel approaches now with GLP-1 agonists class of drugs (injectables) like, exenatide, liraglutide and dulaglutide. No adverse cardiovascular increased risks reported thus far in the trials conducted; however, a distinct advantage clearly seems to be seen with the liraglutide which has been shown to reduce risk of MI, CVA & cardiovascular deaths and renal protection as well shown in the LEADER trial; and therefore, FDA has added this as a very specific distinct indication for the use of the drug wherever cardio-renal protection is required or desirable. GLP-1 agonists also called incretin mimetics work by potentiating the actions of incretin to increase insulin secretion, suppressing the glucagon output, delaying the gastric emptying time so less glucose is absorbed, and also thereby decreasing the food intake as well. There is also weight loss and BP reduction by few mm, some of the very desirable effects in the setting of diabetes. MuniMeterHealth.com, a division of MuniMeter, LLC, is the world premiere online video library on cardiology and the human heart. Our goal is to increase medical education for physicians AND to enhance patient health literacy. This is just the beginning my friends, spread medical knowledge AND love to the world. MuniMeterSTHealth is our latest offering of new content and is available in up to 2160p 4K resolution. Please enjoy and we will do our best to respond to all of your comments/questions/suggestions. We wish you the best in cardiac care and education for the rest of your life! MuniMeter.com is the crown jewel of MuniMeter, LLC. MuniMeter.com is the entire NYC Subway System on film, and more. A major city has never been filmed before in such high capacity and volume, in 1920x1080 HD, by one person - and all handmade. It will never be replicated and it will never be done again. Explore NYC as never before on MuniMeter.com and join the comMUNIty. Dr. Sharad C. Jaitly MD., FACC: Dr. Jaitly is a renowned health educator and entrepreneur. He is Chief Medical Officer and Chief Digital Lecturer of MuniMeterHealth.com (MMH). MMH is a free online video library for individuals from all around the world to learn about a wide spectrum of subjects surrounding cardiology and the human heart. Currently the library consists of several hundred videos in English, but also a few in Hindi. Dr. Jaitly was born in Calcutta and raised in Nagpur, India. He is a graduate from Government Medical College Nagpur, and has received extensive training in Internal Medicine at Mount Sinai (NY) and a specialty in Cardiovascular Diseases at Cornell Medical Center (NY). Dr. Jaitly is board certified in Internal Medicine, Cardiovascular Diseases, Nuclear Cardiology, and Advanced Echocardiography. He is an avid swimmer and loves nature. Muni S. Jaitly: Mr. Jaitly is CEO & Founder of MuniMeter, LLC - a next generation digital content production company and community. He is a former investment banker. Mr. Jaitly received an MBA from Columbia, MS from St. John’s, and BA from NYU. He is a credited Emmy Award winner by NBC Olympics. The future is here. (January 2018) DISCLAIMER: If you are experiencing a medical emergency, please call your doctor immediately and/or and ambulance and/or rush to the nearest hospital. MuniMeterHealth videos should not be used for medical advice. These videos are exclusively available for medical education purposes only. Consult directly with your own doctor for all clinical advice and care. MuniMeterHealth videos were made in good faith and were published during the month and year in parentheses listed directly above the disclaimer. Please be aware that research and knowledge of the human body may have changed since the published date. The content produced is not an authoritative source for address, geographic, medical, or other information. MuniMeter, LLC and MuniMeterHealth do not guarantee authenticity. MuniMeter, LLC is not liable for any behavior triggered by this content. Rather, our comprehensive video platform should be used to simply better understand the human heart, how it functions, and how to keep it healthy. We are doing our very best for you. Live a healthy life and live long! 210 New Hypoglycemic Agents GLP 1 Agonists, What Are They? Copyright © 2018 MuniMeter, LLC

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AG1 is sponsoring today's show. To get 1 year's FREE VITAMIN D and 5 FREE TRAVEL PACKS visit: https://bit.ly/43FwxQl Download my FREE Nutrition Guide HERE: https://bit.ly/3Jeg9yL Order MAKE CHANGE THAT LASTS. US & Canada version https://amzn.to/3RyO3SL, UK version https://amzn.to/3Kt5rUK Why has nutrition - something that should be so simple - become so complicated? With 70% of our diet now consisting of ultra-processed foods and conflicting advice everywhere we look, is it any wonder we're confused about what to eat? Today's returning guest is my good friend, Dr Rupy Aujla, who is on a mission to make healthy cooking accessible and enjoyable for all. He’s a medical doctor, nutritionist and founder of The Doctor's Kitchen and author of five best-selling books. If you haven't heard Rupy's story before, his life was changed after suffering a significant heart condition in 2009. After learning about nutritional medicine, he was able to reverse his condition using a food and lifestyle approach. Today, Rupy is constantly creating tasty recipes that help people optimise their health and he shares them - yes, in his cookbooks - but, also, in his wonderful Doctor’s Kitchen recipe app that helps over 10,000 people each week use evidence-based food and lifestyle medicine, to live healthier, happier lives. In this fantastic conversation, you'll discover: • The science of burning fat and why calorie counting often fails in the real world • Four evidence-based principles for sustainable weight management that don't require strict tracking • Why ultra-processed foods lead to overconsumption and how to naturally reduce them in your diet • The power of single-ingredient foods and how they can transform your health - and why protein at breakfast is crucial for appetite regulation throughout the day • Why eating dinner a little bit earlier, can significantly impact our metabolism and weight • How the quality of our sleep directly affects our food choices and the connection between emotional eating and our relationship with food • Why different diets work for different people, how to find your personal approach and practical tips for implementing healthy changes while maintaining a busy lifestyle This conversation strips away the complexity of nutrition, offering clear, actionable strategies that anyone can implement. So, if you're feeling overwhelmed by conflicting nutrition advice, this conversation offers a practical roadmap forward, showing you how simple - and enjoyable - healthy eating can be. #feelbetterlivemore ----- Show notes available at: https://drchatterjee.com/520 Connect with Dr Rupy: https://www.thedoctorskitchen.com/ https://www.youtube.com/thedoctorskitchen https://twitter.com/doctors_kitchen https://www.instagram.com/doctors_kitchen/ https://www.facebook.com/thedoctorskitchen/ Dr Rupy’s books: Healthy High Protein: Supercharge your energy, feel stronger and live longer US https://amzn.to/4hHZbHu UK https://amzn.to/40UZngR #feelbetterlivemore #feelbetterlivemorepodcast ------- Order MAKE CHANGE THAT LASTS. US & Canada version https://amzn.to/3RyO3SL, UK version https://amzn.to/3Kt5rUK ----- Follow Dr Chatterjee at: Website: https://drchatterjee.com/ Facebook: https://www.facebook.com/drchatterjee Twitter: https://twitter.com/drchatterjeeuk Instagram: https://www.instagram.com/drchatterjee/ Newsletter: https://drchatterjee.com/subscription DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

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