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Novo Nordisk A/S’s shares fell by the most on record after a failed attempt to leapfrog rival Eli Lilly & Co. in the red-hot market for obesity drugs. Novo’s experimental obesity shot CagriSema helped patients lose an average of 20.4% of their weight over 68 weeks, short of the 25% weight loss that Novo had repeatedly predicted for its next-generation product. The study results were roughly in line with the performance of Eli Lilly’s Zepbound shot, which is already on the market and competes with existing Novo treatment Wegovy. Lilly is also working on a next-generation medicine, called retatrutide, which helped people lose up to about 24% of their weight in a mid-sized study last year. WATCH: Emily Field, Barclays’ head of European pharmaceutical research, says the selloff in Novo Nordisk’s shares is an overreaction. Novo’s shares plunged as much as 27% in Copenhagen, and are now down 15% for the year after a runup on the strength of Wegovy sales. Shares of Eli Lilly jumped 10% in premarket US trading. The share decline briefly knocked more than $120 billion from Novo’s market value. The results may suffice for approval for CagriSema, but they leave Novo with issues positioning the drug in the market, Simon Baker, an analyst for Redburn, said in a note. “They sought a superior result to Lilly and got one that is the same,” Baker said. Novo said it will start another trial in the first half of next year to help find out how best to boost patients’ doses. The company expects to seek regulatory approval for CagriSema toward the end of next year, a spokeswoman said in a statement. The study is one of the most anticipated this year in the field. Novo has been counting on CagriSema to help it ward off a growing roster of competitors, led by Eli Lilly, in a weight-loss market that’s predicted to grow to nearly $130 billion by 2030. For more on the results, Paul Sweeney and Norah Mulinda speak with Bloomberg Intelligence senior pharma analyst John Murphy. -------- Watch Bloomberg Radio LIVE on YouTube Weekdays 7am-6pm ET WATCH HERE: http://bit.ly/3vTiACF Follow us on X: https://twitter.com/BloombergRadio Subscribe to our Podcasts: Bloomberg Daybreak: http://bit.ly/3DWYoAN Bloomberg Surveillance: http://bit.ly/3OPtReI Bloomberg Intelligence: http://bit.ly/3YrBfOi Balance of Power: http://bit.ly/3OO8eLC Bloomberg Businessweek: http://bit.ly/3IPl60i Listen on Apple CarPlay and Android Auto with the Bloomberg Business app: Apple CarPlay: https://apple.co/486mghI Android Auto: https://bit.ly/49benZy Visit our YouTube channels: Bloomberg Podcasts: https://www.youtube.com/bloombergpodcasts Bloomberg Television: https://www.youtube.com/@markets Bloomberg Originals: https://www.youtube.com/bloomberg Quicktake: https://www.youtube.com/@BloombergQuicktake

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When it comes to weight loss, there are many factors to consider, including diet, exercise, and medication. One medication that has been gaining popularity for its weight loss benefits is semaglutide. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that was originally developed to help manage type 2 diabetes. However, studies have shown that it can also be effective in promoting weight loss in individuals with obesity.

Understanding Semaglutide Dosing

Semaglutide works by mimicking the effects of GLP-1, which helps regulate appetite and food intake. When used for weight loss, semaglutide is typically administered via subcutaneous injection once a week. The recommended dose for weight loss is higher than the dose used for diabetes management, as studies have shown that higher doses of semaglutide are more effective in promoting weight loss.

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Patients starting on semaglutide for weight loss are usually prescribed a lower dose, which is gradually increased over time to minimize side effects. It is important for patients to follow their healthcare provider’s instructions carefully and not to adjust their dose without consulting them first.

It is essential to note that semaglutide is not a miracle drug and should be used in combination with a healthy diet and regular exercise for best results. It is also not suitable for everyone, so individuals considering semaglutide for weight loss should discuss their medical history and any existing health conditions with their healthcare provider.

Side Effects and Considerations

Like any medication, semaglutide can cause side effects, including nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and diminish over time as the body adjusts to the medication. However, if side effects persist or become severe, patients should contact their healthcare provider.

Patients taking semaglutide should also be aware of the potential risk of hypoglycemia, especially if they are also taking medications for diabetes. It is essential to monitor blood sugar levels regularly and seek medical attention if experiencing symptoms of low blood sugar, such as dizziness, sweating, or confusion.

Additionally, semaglutide has been associated with rare but serious side effects, such as pancreatitis and thyroid tumors. Patients should be monitored regularly by their healthcare provider to detect any potential complications early on.

Conclusion

In conclusion, the recommended semaglutide dose for weight loss is typically higher than the dose used for diabetes management. Patients starting on semaglutide should follow their healthcare provider’s instructions carefully and be aware of potential side effects and considerations.

Ultimately, the decision to use semaglutide for weight loss should be made in consultation with a healthcare provider, taking into account the individual’s medical history and existing health conditions. With the right guidance and support, semaglutide can be a valuable tool in achieving weight loss goals.

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