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Your diet may be doing more harm than good, especially if you carry the APOE4 gene. In this video, psychiatric nurse practitioner Jezel Rosa breaks down how APOE, along with genes like FADS1, COMT, MTHFR, and BDNF, influences fat metabolism, brain inflammation, and cognitive decline risk. Discover why Keto isn’t ideal for everyone, how to support your genes through nutrition and lifestyle, and why genetic testing can offer the clarity you’ve been looking for. 🔬 Curious if your genes are working against your mental health? Let’s explore. 🧬DNA Testing packages: https://2ly.link/261YY 🧪 Mental Health Lab Testing: https://2ly.link/261YZ 🧠 Happy Mind drink: https://www.amare.com/et/lfnarp/132716 📚 Recommended Reading: https://www.levelheadedmind.com/books 🎥 This video was edited by: Rahul Kanchi https://www.linkedin.com/in/rahul-kanchi/ 🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor. You can find a list of international crisis lines here: https://blog.opencounseling.com/suicide-hotlines/ References: Belloy, M. E., Napolioni, V., & Greicius, M. D. (2019). A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward. Neuron, 101(5), 820–838. https://doi.org/10.1016/j.neuron.2019.01.056 Chouinard-Watkins, R., & Plourde, M. (2014). Fatty acid metabolism in carriers of apolipoprotein E epsilon 4 allele: is it contributing to higher risk of cognitive decline and coronary heart disease?. Nutrients, 6(10), 4452–4471. https://doi.org/10.3390/nu6104452 Huang, Y., & Mahley, R. W. (2014). Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiology of disease, 72 Pt A, 3–12. https://doi.org/10.1016/j.nbd.2014.08.025 Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., Voyle, N., Proitsi, P., Witoelar, A., Stringer, S., Aarsland, D., Almdahl, I. S., Andersen, F., Bergh, S., Bettella, F., Bjornsson, S., … Posthuma, D. (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nature genetics, 51(3), 404–413. https://doi.org/10.1038/s41588-018-0311-9 Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018). Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nature reviews. Neurology, 14(11), 653–666. https://doi.org/10.1038/s41582-018-0070-3 Knekt, P., Järvinen, R., Rissanen, H., Heliövaara, M., & Aromaa, A. (2020). Does sauna bathing protect against dementia?. Preventive medicine reports, 20, 101221. https://doi.org/10.1016/j.pmedr.2020.101221 Laukkanen, J. A., & Laukkanen, T. (2018). Sauna bathing and systemic inflammation. European journal of epidemiology, 33(3), 351–353. https://doi.org/10.1007/s10654-017-0335-y Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009). Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. Journal of lipid research, 50 Suppl(Suppl), S183–S188. https://doi.org/10.1194/jlr.R800069-JLR200 Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment. Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.

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Use Code THOMASNY for 33% off Timeline Nutrition’s MitoPure: https://www.timeline.com/lp/nyry-thomas This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Click HERE to Subscribe: https://www.youtube.com/c/ThomasDeLauerOfficial?sub_confirmation=1 Please check out the new Shorts channel, DeLauer Clips and Workouts, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer References https://paulogentil.com/pdf/Exercise%20Dosing%20to%20Retain%20Resistance%20Training%20Adaptations%20in%20Young%20and%20Older%20Adults.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731492/ Timestamps ⏱ 0:00 - Intro 0:51 - 33% off Timeline Nutrition’s MitoPure 1:56 - The Good News 3:17 - Exercise Dosing Over 40 6:42 - Training Requirements for Muscle Maintenance 7:38 - Maintaining Muscle Without Gaining Fat 12:19 - Form & Frequency of HIIT for Fat Loss