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Eli Lilly, the maker of the popular weight loss injection Zepbound, is exploring other ways the drug can help people. In an interview with the Economic Club of Washington, D.C., this week, the company’s CEO, David Ricks, discussed the pharmaceutical giant’s plans for 2025. “These medicines, we think, and we aim to prove, can be used for other things we don’t think about connected to weight,” Ricks said. “These are often called anti-hedonics, so they are reducing that desire cycle. So, next year you’ll see Lilly start large studies in alcohol abuse, in nicotine use, even in drug abuse.” Zepbound is a GLP-1 drug. Those drugs work by mimicking hormones that make you feel satisfied after eating. Researchers have known the mechanism in the brain that regulates food-seeking behaviors. They say it overlaps with the mechanism that regulates why some people develop addiction. However, Ricks said Eli Lilly’s upcoming study will be the first to test the use of these drugs specifically to treat addiction. Zepbound started out under the name Mounjaro as a treatment for Type 2 diabetes. Eli Lilly later discovered patients could use Mounjaro’s active ingredient, tirzepatide, as an off-label prescription to encourage weight loss. Shortly after, the Food and Drug Administration approved a version for weight loss purposes under the name Zepbound. A new study by Loyola University released this week in the journal “Addiction,” found GLP-1 drugs show promise for treating drug and alcohol addiction. Researchers found people addicted to alcohol who also had a prescription for a GLP-1 drug had a 50% lower rate of binging alcohol. They also discovered people with opioid use disorder had a 40% lower rate of overdose. Full Story: https://san.com/cc/eli-lilly-to-test-weight-loss-drug-zepbound-to-treat-addiction/ Follow Straight Arrow News on social media: Facebook: https://www.facebook.com/straightarrownews Twitter: https://twitter.com/StraightArrow__ Instagram: https://www.instagram.com/straightarrownews/ TikTok: https://www.tiktok.com/@straightarrownews For more SAN content: https://san.com/ Sign up for our weekly newsletters: https://san.com/newsletters/ Download the SAN App! Apple: https://apps.apple.com/us/app/straight-arrow-news/id6449258793 Google Play: https://play.google.com/store/apps/details?id=com.straightarrownews

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GLP-1 Medications: High Drug Prices, Compounded Risks, and New Frontiers in Obesity & Addiction Treatment In this episode of Downsized News, hosts Laraine and Christopher Durham discuss recent developments in the world of GLP-1 medications and their implications for weight loss and overall health. They begin by covering former President Donald Trump's remarks on the high cost of GLP-1 drugs like Ozempic and Mounjaro, comparing prices between London and New York. The couple also offers their insights on the complexities of the U.S. healthcare system and its price-setting mechanisms. The episode then moves on to discuss Robert F. Kennedy Jr.'s recent confirmation as the head of Health and Human Services and how his initial skepticism of GLP-1 drugs has softened since his new role. He now acknowledges their importance in treating obesity. Another major story is Nova Nordisk's response to Hims and Hers' Super Bowl ad promoting compounded GLP-1 medications as a cheaper alternative to branded drugs. Nova Nordisk warns consumers about the risks associated with compounded medications. The episode also highlights a massive investment by Xplora in France to boost the production of GLP-1s and antibody-drug conjugates, aiming to meet the growing demand for these medications. A survey of over 2,000 doctors offers insights into the medical community's views on GLP-1s, stressing the importance of combining these medications with healthy lifestyle changes for lasting success. Finally, promising new research shows that semaglutide, a GLP-1 medication, may help reduce alcohol cravings and smoking, opening new possibilities for its use beyond weight loss. Semaglutide & Alchohol USe DIsorder Study JAMA: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2829811 OMADA HEALTH PHYSICIANS SURVEY: https://resourcecenter.omadahealth.com/latest-content/survey-report-primary-care-perspectives-on-glp-1-prescriptions BOOK THE DOWNSIZED AT SEA CRUISE Presented by Mochi Health: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction and Hosts' Weight Loss Journey 01:13 Controversy Over Compounded GLP-1 Medications 04:19 Trump's Take on GLP-1 Drug Prices 09:55 Robert F. Kennedy Jr. as HHS Secretary 13:01 Xplora's Investment in GLP-1 Production 14:11 Doctors' Views on GLP-1 Medications 19:05 Semaglutide's Potential Beyond Weight Loss 21:20 Conclusion and Farewell

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How Testosterone Affects Fat Loss: Real Science of Low-T | Thomas DeLauer: I'm sick of the lack of legitimacy behind testosterone, so let's clear some of this up. I work with a lot of men that are battling Low-T by helping them with their lifestyle at http://www.ThomasDeLauer.com As men age, their testosterone levels decline. This is exacerbated by an increase in SHBG (sex-hormone binding globulin), which binds to testosterone and thus reduces the amount of free testosterone in the body. Low testosterone levels have been linked to obesity and many other health problems, including fatigue, memory problems and reduced muscle and bone mass. So what is the impact of testosterone on body fat? Testosterone and energy - low levels of testosterone are linked with low energy levels. Regaining regular testosterone levels can increase energy and lead to weight loss. Studies have found that testosterone supplementation reduces total body fat percentages. Obesity is often correlated with low testosterone levels in men. Just as testosterone therapy is associated with decreased obesity, losing weight is associated with increased testosterone levels. An article published in 2014 in the journal of Current Opinion in Endocrinology, Diabetes and Obesity looked at the existing data regarding testosterone therapy in overweight and obese men with testosterone deficiency (hypogonadism). -Many weight loss supplements have dangerous side effects or are ineffective -Looked at weight loss, BMI, waist circumference and body composition -Evaluated long-term testosterone therapy -About 40% of obese nondiabetic men and 50% of obese diabetic men over 45 have low levels of free testosterone -Many studies have found that testosterone therapy in obese men is correlated with increased lean body mass, weight loss, decreased BMI and reduced waist circumference. -Weight loss is significant and sustained with long-term testosterone therapy Testosterone plays a part in protein, fat and carbohydrate metabolism. -Testosterone is involved with mitochondrial function and thus energy production and utilization -This interference with energy production is likely why those with low testosterone levels experience a lack of energy -Testosterone therapy has been found to increase lipid oxidation and normalize glucose use in the body. It was found to increase energy and motivation. Weight gain is associated with an 88% increase in body fat and a 12% increase in lean body mass (LBM) and weight loss with a 72% decrease in body fat and a 28% decrease in LBM. -With testosterone therapy LBM has been shown to increase. -Increased LBM means increased energy expenditure at rest -Testosterone therapy is also associated with improved cardiometabolic function Testosterone deficiency is linked with a decrease in energy metabolism from fat and an increase in energy metabolism from glucose. -Testosterone therapy has been shown to increase lipid metabolism Safety? Safety is the main concern with testosterone replacement therapy. Possible risks discussed in literature include: -Increased risk of prostate and breast cancer -Liver toxicity and tumors -Sleep apnea exacerbation -Testicular infertility and atrophy It is necessary to talk with your doctor before starting testosterone therapy. Summary: If you are a male struggling to lose weight, testosterone therapy is a promising treatment to help with not only weight loss but body composition, energy levels and overall health. References: 1. Dose-dependent effects of testosterone on regional adipose tissue distribution… http://press.endocrine.org/doi/10.1210/jc.2003-031492?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed 2. Testosterone and weight loss: the evidence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154787/ 3. Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet… https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054608/ 4. The benefits and risks of testosterone replacement therapy: a review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701485/

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