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Welcome back to The Visser Podcast! 👋 Today, I’m diving deep into Retatrutide, often called the 'triple G' agonist, and why it's poised to be a game-changer in metabolic health and longevity. We're talking about the next frontier in weight management and beyond. What is Retatrutide? This groundbreaking compound targets three crucial hormones – GLP-1, GIP, and glucagon. This unique multi-hormonal approach has shown truly remarkable results, even surpassing current leading medications like tirzepatide and semaglutide in weight loss efficacy. The Latest Clinical Insights: In its Phase 2 trials, participants saw an average of 24.2% body weight reduction (that’s about 58 lbs!) over 48 weeks. Some even experienced up to 31% loss, which is quite significant and required careful dose management. We're eagerly anticipating more data from the ongoing Phase 3 TRIUMPH program. Look out for results on obesity and OA knee studies coming in 2025, with further insights into obstructive sleep apnea (OSA) and type 2 diabetes expected by mid-2026. Plus, we'll see Phase 2b renal function trial results in Q4 2025. Safety & What We Know So Far: Like many medications in this class, common side effects include nausea and abdominal pain. The rapid weight loss observed means careful dosing is key, with some participants needing to increase caloric intake to stabilize weight. We did see one reported case of kidney stones, though its direct link to the drug is still being investigated. Beyond Weight Loss: The Broader Benefits: What truly excites me are the potential benefits beyond just weight loss. Early data suggests significant improvements in comorbidities like reduced knee pain, better cholesterol levels, and even improved fatty liver disease. There's promising data pointing to liver fat reduction and potential benefits for MASH (metabolic dysfunction-associated steatohepatitis). The Competitive Edge: Retatrutide could really solidify Eli Lilly's leadership in obesity therapeutics, potentially offering a new solution for those who haven't responded to existing therapies. It's an exciting time with new innovations like oral GLP-1 pills and once-yearly shots also in the pipeline. Key Upcoming Milestones: 2025: Phase 3 obesity/OA knee data release. 2026: Full Phase 3 results (TRIUMPH-1/-2) and potential FDA submission. 2027: Head-to-head trial vs. tirzepatide (TRIUMPH-5). This medication represents a significant step forward in our journey toward better health and longevity. I'll keep you updated as more data emerges! Let me know your thoughts and questions in the comments below! 👇 Relevant Studies & Resources: https://doi.org/10.1093/ehjcvp/pvad080 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915087 https://sciencehub.novonordisk.com/content/dam/sciencehub/global/en/congresses-and-scientific-publications/congresses/ow2024/Garvey/documents/Garvey_OASIS_4_OW24-oral_Final_23Oct24.pdf https://doi.org/10.1001/jamainternmed.2024.2525 https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-successful-phase-3-study-showing-benefit https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal https://www.boehringer-ingelheim.com/human-health/metabolic-diseases/survodutide-top-line-results-mash-fibrosis https://ir.altimmune.com/news-releases/news-release-details/correction-altimmune-presents-results-phase-2-mri-based-body https://investors.amgen.com/static-files/0176d78e-920b-45b3-b9cc-a727e58e80da https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine https://ir.vikingtherapeutics.com/2024-11-04-Viking-Therapeutics-Reports-New-Data-from-VK2735-Obesity-Program-at-ObesityWeek-R-2024 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915082 https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915251 https://medically.roche.com/global/en/medical-material.3d8d7ba5-5a5d-4b7d-bed7-f4f5e05e5a6e.qr.html?cid https://www.kailera.com/press-release/jiangsu-hengrui-pharmaceuticals-and-kailera-therapeutics-report-positive-topline-data-from-8-mg-dose-of-phase-2-obesity-trial-of-glp-1-gip-receptor-dual-agonist-hrs9531/

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Apple cider vinegar (ACV) has been hailed as a miracle cure for various health issues, including weight loss and improved digestion. For those following a ketogenic diet, ACV can be a game-changer in elevating the overall experience and results of the diet. Truly Keto ACV is a specialized version of ACV that is specifically formulated to complement a ketogenic lifestyle. In this article, we will explore the benefits of Truly Keto ACV and how it can enhance your ketogenic journey.

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Truly Keto ACV is made from organic apples and contains the “mother,” which is a colony of beneficial bacteria that contribute to its health benefits. The combination of ACV and a ketogenic diet can aid in weight loss, improve digestion, and boost overall health. The acidity of ACV can also help to regulate blood sugar levels and reduce cravings for sugary foods.

One of the key benefits of Truly Keto ACV is its ability to support gut health. The “mother” in ACV contains probiotics that can help to balance the bacteria in the gut and improve digestion. A healthy gut is essential for overall well-being and can contribute to better absorption of nutrients from food.

In addition to its impact on weight loss and gut health, Truly Keto ACV has also been shown to have anti-inflammatory properties. Chronic inflammation is linked to various health issues, including obesity, cardiovascular disease, and autoimmune disorders. By incorporating Truly Keto ACV into your ketogenic lifestyle, you may be able to reduce inflammation in the body and support overall health.

How to Incorporate Truly Keto ACV into Your Ketogenic Diet

There are various ways to incorporate Truly Keto ACV into your ketogenic diet. One popular method is to mix a tablespoon of ACV with water and drink it before meals. This can help to stimulate digestion and improve nutrient absorption. You can also use Truly Keto ACV as a salad dressing or marinade for meats and vegetables.

Another way to reap the benefits of Truly Keto ACV is to use it in cooking and baking. You can add a splash of ACV to soups, stews, and sauces to enhance the flavor and nutritional profile of your meals. Truly Keto ACV can also be used in keto-friendly dessert recipes to add a tangy twist to sweet treats.

For those who prefer a more convenient option, Truly Keto ACV is also available in capsule form. This allows you to easily incorporate ACV into your daily routine without having to deal with the taste or acidity of liquid ACV. Simply take the recommended dose of Truly Keto ACV capsules with water and enjoy the benefits of ACV on the go.

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Q: Is Truly Keto ACV safe to consume on a ketogenic diet?

A: Yes, Truly Keto ACV is keto-friendly and can be safely consumed as part of a ketogenic lifestyle. It can enhance the effects of the diet and provide additional health benefits.

Q: How often should I take Truly Keto ACV?

A: The recommended dose of Truly Keto ACV can vary depending on your individual health goals and preferences. It is generally safe to consume ACV daily, either in liquid form or as capsules, to experience its benefits.

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Q: Are there any side effects of taking Truly Keto ACV?

A: While ACV is generally safe for most people, some individuals may experience side effects such as upset stomach or throat irritation. It is important to start with a small dose of Truly Keto ACV and monitor how your body responds to it.

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