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Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.com In this journal club episode, Victoria Field is joined by Dr. Angela Poff and Dr. Dominic D’Agostino to dive into two groundbreaking studies shaping our understanding of metabolism and its role in health and disease. The team explores the nuances of a recent randomized controlled trial on ketogenic diets, free sugar restriction, and their effects on glucose tolerance, lipid metabolism, and the gut microbiome. Then, they tackle a cutting-edge study uncovering the molecular mechanisms of ketogenic diets in reshaping cancer metabolism through lysine beta-hydroxybutylaration. From the clinical implications of these findings to the potential of ketone supplementation, this episode is packed with insights for researchers, clinicians, and health enthusiasts. Don’t miss the opportunity to learn how these discoveries could shape the future of precision medicine. 🔍 Study 1: Ketogenic diet but not free-sugar restriction alters glucose tolerance, lipid metabolism, peripheral tissue phenotype, and gut microbiome: RCT https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00381-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379124003811%3Fshowall%3Dtrue 🔍 Study 2: Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation: https://www.nature.com/articles/s42255-024-01093-w Referenced study related to cardiometabolic health - Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis: The KETO Trial: https://www.jacc.org/doi/10.1016/j.jacadv.2024.101109 Special thanks to the sponsors of this episode: Genova Connect: Receive 15% off any of their tests with code metaboliclink here: https://www.gdx.net/themetaboliclink Fatty15: Get 15% off their 90-day subscription Starter Kit with the code METABOLICLINK here: https://partners.fatty15.com/METABOLICLINK Maui Nui: Get 15% off your first order of Maui Nui with the code METABOLICLINK by visiting this link: https://mauinuivenison.com/metaboliclink In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. Listen to this episode on your favorite podcast player, and if you like it, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

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Semaglutide is a relatively new drug in the weight loss market that has been making waves for its effectiveness in helping people shed unwanted pounds. Originally developed as a treatment for type 2 diabetes, semaglutide has been found to have the added benefit of promoting weight loss in individuals struggling with obesity. However, like any medication, it is essential to understand how to use semaglutide effectively to maximize its weight loss benefits while minimizing potential side effects.

Choosing the Right Dosage

One of the most crucial aspects of using semaglutide for weight loss is determining the right dosage for your individual needs. Semaglutide is typically prescribed in doses ranging from 0.25mg to 2.4mg, with higher doses typically being more effective for weight loss. However, it is essential to work closely with your healthcare provider to find the dosage that is both safe and effective for you. Starting at a lower dose and gradually increasing it over time can help minimize side effects while still achieving significant weight loss results.

Additionally, it is essential to follow your healthcare provider’s instructions carefully when it comes to taking semaglutide. Depending on the brand of semaglutide prescribed, it may need to be injected weekly or daily, so understanding the proper administration technique is crucial for achieving optimal results.

It is also essential to be patient when starting semaglutide for weight loss. While some individuals may see rapid weight loss results, others may take longer to experience significant changes. Consistency with taking the medication as prescribed and following a healthy diet and exercise plan will be key to long-term success.

Managing Side Effects

Like any medication, semaglutide can cause side effects in some individuals. Common side effects of semaglutide include nausea, diarrhea, and constipation. These side effects usually subside as your body adjusts to the medication, but if they persist or become severe, it is essential to contact your healthcare provider.

In rare cases, semaglutide can also cause more serious side effects such as pancreatitis or thyroid tumors. It is essential to be aware of the potential risks associated with semaglutide and to contact your healthcare provider immediately if you experience any concerning symptoms.

To help manage side effects and improve the effectiveness of semaglutide for weight loss, it is essential to stay hydrated, eat a balanced diet, and engage in regular physical activity. These lifestyle changes can help support your weight loss journey while minimizing any unwanted side effects of the medication.

Monitoring Your Progress

Regular monitoring of your weight loss progress is crucial when using semaglutide. Your healthcare provider may recommend frequent check-ins to track your weight loss, assess any side effects, and make any necessary adjustments to your treatment plan. Keeping a food diary, tracking your physical activity, and monitoring your overall health can also help you stay on track with your weight loss goals.

It is also essential to communicate openly with your healthcare provider about any challenges or concerns you may have while taking semaglutide. Your healthcare provider can offer support, guidance, and resources to help you navigate your weight loss journey successfully.

Remember that weight loss is a journey, and it is essential to celebrate your successes along the way, no matter how small they may seem. With the right mindset, support system, and treatment plan, you can achieve your weight loss goals with the help of semaglutide.

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