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Time stamps 0:30 what are ketones The 3 ketone bodies are acetone, acetoacetate and beta hydroxybutyrate Your liver makes ketones from acetyl-CoA 1:02 why does breath smell weird on keto (keto breath) 1:43 what is beta hydroxybutyrate (the best ketone for brain health) 1:55 how are ketones made (ketogenesis) Ketogenesis is the pathway that makes ketones, ketogenesis happens in your liver only Long chain fatty acids are oxidized in the mitochondria to yield acetyl-CoA (beta oxidation) In a ketogenic state / keto metabolic state the acetyl-coa is favourably directed into ketogenesis instead of the tricarboxylic acid / citric acid cycle Under normal conditions (normal carbohydrate diet / fed) the long chain fatty acids are oxidized to acetyl-coa and the acetyl-coa will then enter the tricarboxylic acid / citric acid cycle In starvation states or proper keto diets, if the TCA cycle is slowed or deplete of intermediates then the acetyl-coa enters ketogenesis Ketogenesis should only happen in extreme starvation or on true keto diets 3:13 ketogenic pathway biochemistry Enzymes essential to ketogenesis… Thiolase, HMG-CoA synthase, HMG-CoA lyase, acetoacetate decarboxylase, betahydroxybutyrate dehydrogenase 4:47 acetoacetate can be cleaved to give CO2, acetone and betahydroxybutyrate 5:37 what is BHB 6:46 how do ketones give you energy (metabolism basics) Acetyl-coa is the common entry point to the tricarboxylic acid / citric acid cycle - glucose, fatty acids and amino acids can all be metabolized into ACoA ACoA can enter the TCA cycle for complete oxidation and to yield large amounts of energy Ketogenesis is when you make ketones from ACoA in the liver, the ketones then enter circulation, travel to the brain where they are converted back into ACoA, now in your brain the ACoA enters the TCA cycle for complete and rapid oxidation thus yielding large amounts of energy 9:02 How to get into ketosis / when are you in ketosis 9:37 what happens when you are starving 10:39 what is keto diet Keto diet macro distribution 5% calories from carbohydrate 25% calories from protein 70% calories from fat 11:12 why is starvation bad for you (protein sparing effect / TCA cycle depletion) 11:59 long term fasting / prolonged fasting diets 13:40 ketosis acidifies your blood and damages organs (ketoacidosis)

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We talk a lot about attraction on this channel. And many of you say you feel "unattractive". A lot of this can be fixed if we take a look at our diet. So today, we will be talking about how diet affects your appearance. Ever wondered how your diet impacts your skin, hair, and overall appearance? In this video, we dive into the fascinating connection between what you eat and how you look. From glowing skin to shiny hair, discover the foods that can enhance your natural beauty and those that might be holding you back. Join us as we explore the science behind diet and appearance, and learn how to make simple dietary changes that can lead to stunning results. Disclaimer: We are not professional doctors or nutritionists. The information provided in this video is for informational purposes only and should not be considered as medical advice. Always consult with a healthcare professional or a registered dietitian before making any significant changes to your diet or health routine. Your well-being is important, and professional guidance is essential for personalized advice. Credits: Writer: Syazwana Amirah Editor: Caitlin McColl Script Manager: Kelly Soong Voice Over: Amanda Silvera (http://www.youtube.com/amandasilvera ) Animation: Avery (new animator) Youtube Manager: Cindy Cheong DISCLAIMER: This video may contain information that can be triggering to those suffering from eating disorders or who have an unhealthy relationship with food or body image. If you are struggling, we highly advise you to seek help from a qualified mental health professional. REFERENCES Aragno, M., & Mastrocola, R. (2017). Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease. Nutrients, 9(4), 385. https://doi.org/10.3390/nu9040385 Havlíček, J., & Lenochova, P. (2006). The Effect of Meat Consumption on Body Odor Attractiveness. Chemical Senses, 31(8), 747–752. doi.org/10.1093/chemse/bjl017 Monjazeb, S. (2021, December 8). The Effects of Alcohol on Skin. U.S. Dermatology Partners. Retrieved March 1, 2023, from www.usdermatologypartners.com/blog/effects-of-alcohol-on-skin/ Prentice, A. M., & Jebb, S. A. (2003). Fast foods, energy density and obesity: a possible mechanistic link. Obesity Reviews, 4(4), 187–194. doi.org/10.1046/j.1467-789x.2003.00117.x Van Drielen, K., Gunn, D., Noordam, R., Griffiths, C. E., Westendorp, R. G. J., De Craen, A. J. M., & Van Heemst, D. (2015). Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age. Age, 37(3). doi.org/10.1007/s11357-015-9771-3 Vrcek, I., Ozgur, O., & Nakra, T. (2016). Infraorbital dark circles: A review of the pathogenesis, evaluation and treatment. Journal of Cutaneous and Aesthetic Surgery, 9(2), 65. doi.org/10.4103/0974-2077.184046 Xie, J., Wang, D., Ling, S., Yang, G., Yang, Y., & Chen, W. (2019). High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems. Frontiers in Neuroscience, 13. doi.org/10.3389/fnins.2019.01271

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