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https://www.youtube.com/channel/UCS8F5SbTBIUv_hj5Z0_Y5ng?sub_confirmation=1 Curious about how GLP-1 agonists like Semaglutide (Wegovy) are transforming diabetes and weight loss management? In this video, we dive into the science behind GLP-1 agonists, explaining how these medications mimic the body’s natural hormones to regulate blood sugar and promote significant weight loss. Learn about the benefits and how to properly use these medications, and hear from experts on why GLP-1 agonists are considered a breakthrough in modern medicine. Whether managing diabetes or looking for effective weight loss solutions, this video covers everything you need to know!

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Obesity specialist Dr Holly Lofton reveals how she chooses the right GLP-1 for each patient, and the importance of staying on label. https://www.medscape.com/viewarticle/1000524?src=soc_yt -- TRANSCRIPT -- Hi. I'm Dr Holly Lofton. I'm a board-certified obesity medicine specialist, and I direct the medical weight management program at NYU Langone Health. With all the excitement about GLP-1 agonists, I get many questions from providers about which antiobesity drug they should prescribe. I'll tell you the methods that I use to determine which drug is best for which patient. Of course, we want to make sure that we're treating the right condition. If the patient has type 2 diabetes, we tend to give them medication that is indicated for type 2 diabetes. Many GLP-1 agonists are available in a diabetes version and a chronic weight management or obesity version. If a patient has diabetes and obesity, they can receive either one. If a patient has only diabetes but not obesity, they should be prescribed the diabetes version. For obesity without diabetes, we tend to stick with the drugs that are indicated for chronic weight management. Let's go through them. Exenatide. In chronological order of approval, the first GLP-1 drug that was used for diabetes dates back to exenatide (Bydureon). Bydureon had a partner called Byetta (also exenatide), both of which are still on the market but infrequently used. Some patients reported that these medications were inconvenient because they required twice-daily injections and caused painful injection-site nodules. Diabetes drugs in more common use include liraglutide (Victoza) for type 2 diabetes. It is a daily injection and has various doses. We always start low and increase with tolerance and desired effect for A1c. Liraglutide. Victoza has an antiobesity counterpart called Saxenda. The Saxenda pen looks very similar to the Victoza pen. It is a daily GLP-1 agonist for chronic weight management. The SCALE trial demonstrated 8%-12% weight loss with Saxenda. Those are the daily injections: Victoza for diabetes and Saxenda for weight loss. Our patients are very excited about the advent of weekly injections for diabetes and weight management. Ozempic is very popular. It is a weekly GLP-1 agonist for type 2 diabetes. Many patients come in asking for Ozempic, and we must make sure that we're moving them in the right direction depending on their condition. Semaglutide. Ozempic has a few different doses. It is a weekly injection and has been found to be quite efficacious for treating diabetes. The drug's weight loss counterpart is called Wegovy, which comes in a different pen. Both forms contain the compound semaglutide. While all of these GLP-1 agonists are indicated to treat type 2 diabetes or for weight management, Wegovy has a special indication that none of the others have. In March 2024, Wegovy acquired an indication to decrease cardiac risk in those with a BMI ≥ 27 and a previous cardiac history. This will really change the accessibility of this medication because patients with heart conditions who are on Medicare are expected to have access to Wegovy. Tirzepatide. Another weekly injection for treatment of type 2 diabetes is called Mounjaro. Its counterpart for weight management is called Zepbound, which was found to have about 20.9% weight loss over 72 weeks. These medications have similar side effects in differing degrees, but the most-often reported are nausea, stool changes, abdominal pain, and reflux. There are some other potential side effects; I recommend that you read the individual prescribing information available for each drug to have more clarity about that. It is important that we stay on label for using the GLP-1 receptor agonists, for many reasons. One, it increases our patients' accessibility to the right medication for them, and we can also make sure that we're treating the patient with the right drug according to the clinical trials. When the clinical trials are done, the study populations demonstrate safety and efficacy for that population. But if we're prescribing a GLP-1 for a different population, it is considered off-label use. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/1000524?src=soc_yt

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Is Pfizer’s new danuglipron pill groundbreaking for weight loss? Join us as we compare the oral GLP-1 agonists semaglutide vs. danuglipron, and detail the rise of GLP-1 pills over injections for weight loss. #ozempic #rybelsus For more information about this topic: https://brianyeungnd.com/2023/07/06/semaglutide-vs-danuglipron/ Get EXCLUSIVE content and SUPPORT us: https://ko-fi.com/brianyeungnd 0:00 Intro 1:02 Challenges of GLP-1 pills 2:03 How semaglutide pills works 2:45 How danuglipron pills works 3:32 Semaglutide vs Danuglipron 4:50 Caveats to the comparison 7:05 GLP-1 pills vs injections **************** Learn more about: Summary of all new GLP-1 agonists (updated): Ozempic vs Mounjaro: https://youtu.be/Nsh3tE4WmJw GLP-1 Agonists for Weight Loss: https://youtu.be/U52FTYIQolY Wegovy, Ozempic, or Rybelsus: Which Semaglutide is Right for You? https://youtu.be/isMnb-Oozqk Dr. Brian Yeung, ND: https://brianyeungnd.com/about/ **************** DISCLAIMERS Affiliate links: Please keep in mind that we may receive a commission when you click on our links and make a purchase. This, however, has no bearing on our reviews and comparisons. Content: All statements made are opinions and not stated as fact. While Dr. Brian and his team makes every effort to fact check the information presented, mistakes can still be made. Dr. Brian and his team are not responsible for any errors or omissions in the information provided. The intent of this channel is not to malign or harm the reputation of any individual, company, or organization. All criticisms are made in good faith and with the aim of providing constructive feedback. Copyright: All content, including but not limited to videos, designs, and captions, produced by Dr. Brian is protected under copyright law. Any unauthorized reproduction, distribution, or display of our content, in part or in whole, is strictly prohibited. We do not give permission for anyone to translate and/or reupload our videos, designs, or captions on YouTube or other social media platforms. Any such activity will be considered a violation of our intellectual property rights and may result in legal action. Medical: Dr. Brian Yeung, ND received his Doctor of Naturopathic Medicine degree from the Canadian College of Naturopathic Medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Yeung is currently a practicing Naturopathic Doctor with additional prescribing authority and IV therapy certification in Ontario. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Yeung and you. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. BrianYeungND and Dr. Brian Yeung, ND are not liable or responsible for any advice, course of treatment, diagnosis or any conclusions drawn, services or product you obtain through this video or site.

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