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This animated video summarizes a network meta-analysis of randomized clinical trials comparing the effects of SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors on mortality in patients with type 2 diabetes. Read the article at: https://ja.ma/2H8FpIo. Key Points: Question: How do sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors compare in reducing mortality and cardiovascular events in patients with type 2 diabetes? Findings: In this network meta-analysis that includes 236 trials with 176 310 participants, the use of SGLT-2 inhibitors or GLP-1 agonists was significantly associated with lower all-cause mortality compared with the control groups (placebo or no treatment) (hazard ratio [HR], 0.80, and HR, 0.88, respectively) and with DPP-4 inhibitors (HR, 0.78, and HR, 0.86, respectively). Meaning: In patients with type 2 diabetes, the use of SGLT-2 inhibitors or GLP-1 agonists was associated with better mortality outcomes than DPP-4 inhibitors.
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Have you ever wondered just how much cardio you have to do to burn one pound of body fat? I'm on the Rogue Echo Bike today—one of the toughest cardio machines out there—and I'm on a mission to find out. A pound of fat is about 3500 calories, so if I want to make a dent in that, I have some serious work to do. My goal is to burn as many calories as I can in one minute. Once I have that number, we'll do a little math and, voila, we'll have our answer. Spoiler alert. It's depressing. I started off strong, but, like all who dare push themselves on this bike, I soon found myself in a dark place. In the end, I burned 62 calories in one hellish minute. Not bad, right? I mean, hey, you try it. But here’s the kicker. To burn a pound of body fat, I’d need 55 more minutes at this utterly unsustainable pace, and that’s not happening. Even the fittest athletes can only keep up a work rate of about 15 calories a minute on this bike. For non-athletes, figure it's 10-12. At that rate, it would take 5-6 hours to burn just one pound of fat…and ain't nobody got time for that. So if you’ve ever wondered why people say “You can’t out train a bad diet,” there's your answer. Note: If Rogue Fitness is watching, you should issue a 60 second Rogue Echo Bike challenge as a sequel to the 50 cal challenge! #RogueEchoBike #assaultbike #crossfit #weightloss #loseweight
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