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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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Kaffee ist eines der beliebtesten Getränke weltweit und hat eine lange Geschichte als Genussmittel. Allerdings gibt es auch immer wieder Diskussionen darüber, ob Kaffee auch bei anderen gesundheitlichen Aspekten eine Rolle spielen kann. Eine Frage, die immer wieder auftaucht, ist, ob Kaffee beim Abnehmen helfen kann. In diesem Artikel wollen wir wissenschaftliche Einsichten zu diesem Thema betrachten und herausfinden, ob Kaffee tatsächlich eine Rolle beim Abnehmen spielen kann.

Der Einfluss von Kaffee auf den Stoffwechsel

Eine der Hauptfragen bei der Diskussion um die Rolle von Kaffee beim Abnehmen ist, ob Kaffee den Stoffwechsel beeinflussen kann. Studien haben gezeigt, dass Koffein, das in Kaffee enthalten ist, den Stoffwechsel ankurbeln kann, was zu einem erhöhten Kalorienverbrauch führen kann. Wenn der Stoffwechsel schneller arbeitet, kann dies dazu führen, dass der Körper mehr Energie verbrennt, was wiederum beim Abnehmen helfen könnte.

Ein weiterer wichtiger Aspekt ist, dass Kaffee auch die Fettverbrennung unterstützen kann. Koffein kann die Freisetzung von Fettsäuren aus den Fettzellen erhöhen, was diese als Energiequelle verfügbar macht. Das könnte dazu beitragen, dass der Körper vermehrt Fett verbrennt, was wiederum zu einer Gewichtsreduktion führen könnte.

Es ist wichtig anzumerken, dass der Einfluss von Kaffee auf den Stoffwechsel von Person zu Person variieren kann. Einige Menschen reagieren empfindlicher auf Koffein als andere und könnten daher einen stärkeren Effekt auf ihren Stoffwechsel haben. Es ist daher ratsam, individuell zu beobachten, wie der Konsum von Kaffee sich auf den eigenen Körper auswirkt.

Weitere Potenziale von Kaffee beim Abnehmen

Neben dem direkten Einfluss auf den Stoffwechsel gibt es auch weitere potenzielle Wege, wie Kaffee beim Abnehmen helfen könnte. Zum Beispiel könnte Kaffee das Hungergefühl reduzieren. Studien haben gezeigt, dass Koffein das Zentrum im Gehirn beeinflussen kann, das für das Hungergefühl verantwortlich ist. Wenn das Hungergefühl unterdrückt wird, könnte dies dazu führen, dass man weniger isst und somit weniger Kalorien zu sich nimmt.

Ein weiterer interessanter Aspekt ist, dass Kaffee auch die körperliche Leistungsfähigkeit steigern kann. Das Koffein in Kaffee kann dazu beitragen, dass man sich energiegeladener und fitter fühlt, was wiederum zu einer höheren Motivation für sportliche Aktivitäten führen könnte. Durch mehr Bewegung wiederum könnte man mehr Kalorien verbrennen und somit beim Abnehmen unterstützt werden.

Es gibt auch Hinweise darauf, dass Kaffee die Fettverdauung hemmen könnte. Einige Studien legen nahe, dass Koffein die Lipolyse hemmen kann, was die Aufspaltung von Fetten im Körper verlangsamen könnte. Wenn der Körper langsamer Fette verdaut, könnte dies dazu führen, dass weniger Fett im Körper gespeichert wird, was ebenfalls beim Abnehmen helfen könnte.

Wichtige Faktoren beim Kaffeekonsum für das Abnehmen

Beim Konsum von Kaffee in Bezug auf das Abnehmen gibt es einige wichtige Faktoren zu beachten. Zum einen ist es wichtig, den Kaffee ohne Zucker und Milch zu konsumieren, da diese Zusätze zusätzliche Kalorien enthalten könnten. Schwarzer Kaffee oder Kaffee mit einem Schuss Milch ohne Zucker sind daher die besseren Optionen für den Gewichtsverlust.

Des Weiteren ist die Menge an Kaffee, die man konsumiert, entscheidend. Eine moderate Menge an Kaffee pro Tag wird in der Regel als unbedenklich angesehen und könnte sogar einige gesundheitliche Vorteile mit sich bringen. Zu viel Kaffee kann jedoch zu negativen Effekten führen, wie erhöhtem Blutdruck oder Schlafstörungen, die sich wiederum negativ auf den Abnehmprozess auswirken könnten.

Zuletzt ist es wichtig, den Kaffee nicht als alleiniges Mittel zum Abnehmen zu betrachten. Um langfristig und gesund abzunehmen, ist eine ausgewogene Ernährung und ausreichend Bewegung unerlässlich. Kaffee kann dabei unterstützen, sollte jedoch nicht als Wundermittel angesehen werden.

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Insgesamt gibt es also einige Hinweise darauf, dass Kaffee beim Abnehmen eine gewisse Rolle spielen könnte. Durch seinen Einfluss auf den Stoffwechsel, die Fettverbrennung, das Hungergefühl und die körperliche Leistungsfähigkeit könnte der Konsum von Kaffee den Abnehmprozess unterstützen. Es ist jedoch wichtig, den Kaffee in Maßen zu genießen und auf Zucker und Milchzusätze zu verzichten. Zudem sollte der Kaffee nicht als alleiniges Mittel zum Abnehmen angesehen werden, sondern als unterstützender Faktor neben einer ausgewogenen Ernährung und ausreichend Bewegung.

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Here is why I quit the carnivore diet… Avoid fast food garbage and eat real foods. This is why I created Lineage Provisions. Giving you real foods in the most convenient way. Check us out: http://lineageprovisions.com/psmdyt The carnivore diet is a very powerful short-term intervention that helped me reverse all my gut and skin conditions and has helped thousands of people improve their overall health… If you are thriving, keep doing what you are doing… But if you are not, there are a few things to reconsider when structuring your diet… Healthy carbohydrates from fruit and honey are key to optimal hormonal health… There is no scientific evidence to suggest that carbohydrates from fruit and honey are harmful for humans… In this video, I am going to review many research studies on the benefits of carbohydrates for humans… It's always meat / organs / fruit / honey / raw dairy… This is an ANIMAL-BASED diet, and I believe this is the most optimal diet for humans on the planet... Check out my ANIMAL-BASED CALCULATOR here: https://www.paulsaladinomd.co/ab-guide#calculator 00:00 Intro 01:53 My story 04:42 The role of insulin 07:45 The pitfalls of keto diets 12:26 The importance of carbohydrates 16:43 Fruit and honey 22:35 What's the takeaway? STUDIES 👇 Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes - https://pubmed.ncbi.nlm.nih.gov/17686957/ Fructose in healthy adults - https://pubmed.ncbi.nlm.nih.gov/3781328/ Fructose in mice - https://pubmed.ncbi.nlm.nih.gov/19637282/ A Short-Term Ketogenic Diet Impairs Markers of Bone Health in Response to Exercise - https://pubmed.ncbi.nlm.nih.gov/32038477/ Changes of thyroid hormonal status in patients receiving ketogenic diet - https://pubmed.ncbi.nlm.nih.gov/28076316/ Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men - https://pubmed.ncbi.nlm.nih.gov/17785367/ Isocaloric carbohydrate deprivation induces protein catabolism despite a low T3-syndrome in healthy men - https://pubmed.ncbi.nlm.nih.gov/11167929/ Modification of immune responses to exercise by carbohydrate, glutamine and anti-oxidant supplements - https://pubmed.ncbi.nlm.nih.gov/11050539/ Ketosis leads to increased methylglyoxal production on the Atkins diet - https://pubmed.ncbi.nlm.nih.gov/16037240/ Supplemental Watermelon Juice Attenuates Acute Hyperglycemia-Induced Macro-and Microvascular Dysfunction in Healthy Adults: https://pubmed.ncbi.nlm.nih.gov/34510203/ The Effect of Watermelon Juice Supplementation on Heart Rate Variability and Metabolic Response during an Oral Glucose Challenge - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967111/ Drinking orange juice increases total antioxidant status and decreases lipid peroxidation in adults -https://pubmed.ncbi.nlm.nih.gov/24476220/ Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation - https://pubmed.ncbi.nlm.nih.gov/10477529/ Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413159/ A Review on the Protective Effects of Honey against Metabolic Syndrome - https://www.mdpi.com/2072-6643/10/8/1009 Effects of natural honey consumption in diabetic patients: an 8-week randomized clinical trial - https://pubmed.ncbi.nlm.nih.gov/19817641/ Follow me on social media: Instagram: https://www.instagram.com/paulsaladinomd Tik Tok: https://www.tiktok.com/paulsaladinomd2 Twitter: https://twitter.com/paulsaladinomd Send a message to the team: [email protected] Disclaimer: Dr. Paul Saladino received his medical degree from the University of Arizona Medical School. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Saladino is a licensed physician in California, but he no longer practices in any state and does not see patients so he can focus on educating people as a full time activity. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Saladino and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. #carnivore #animalbaseddiet #dayofeating #carnivorediet #animalbased #fitness #health #seedoils

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