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Pare de sofrer com a Farmacologia!!! Seja um aluno R2A! https://farmacologiafacil.com/farmacologia-apl-r2a/ O GLP-1, ou glucagon-like peptide 1, é um hormônio produzido pelas células L do intestino delgado em resposta à ingestão de alimentos. Ele desempenha vários papéis importantes no organismo, especialmente na regulação da glicose sanguínea e do metabolismo energético. Aqui estão alguns dos principais efeitos do GLP-1: Estímulo da insulina: O GLP-1 aumenta a secreção de insulina pelas células beta do pâncreas em resposta aos níveis elevados de glicose no sangue. Isso ajuda a reduzir os níveis de glicose após as refeições, contribuindo para a regulação dos níveis de açúcar no sangue. Inibição da liberação de glucagon: O GLP-1 inibe a secreção de glucagon, um hormônio que aumenta os níveis de glicose no sangue ao promover a gliconeogênese e a glicogenólise no fígado. Essa inibição contribui para a diminuição dos níveis de glicose no sangue. Retardamento do esvaziamento gástrico: O GLP-1 retarda o esvaziamento gástrico, ou seja, o processo pelo qual os alimentos são liberados do estômago para o intestino delgado. Isso ajuda a reduzir os picos de glicose após as refeições, mantendo os níveis de açúcar no sangue mais estáveis. Supressão do apetite: O GLP-1 atua no cérebro para reduzir o apetite e promover a sensação de saciedade, o que pode ajudar no controle do peso corporal. Proteção das células beta pancreáticas: Além de estimular a secreção de insulina, o GLP-1 também pode ter efeitos protetores nas células beta do pâncreas, ajudando a preservar sua função e prevenir sua morte. Devido a esses efeitos, os análogos do GLP-1 são utilizados no tratamento do diabetes tipo 2 para ajudar a controlar os níveis de glicose no sangue e também podem ter potencial no tratamento da obesidade.

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