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Dr. Riccardo De Giorgi is a Clinical Lecturer at the University of Oxford’s Department of Psychiatry and a senior psychiatric trainee with Oxford Health NHS Foundation Trust. Dr. De Giorgi is deeply engaged in clinical practice and academic research, focusing on treatment-resistant mood disorders. His work explores the role of immunological and metabolic factors in mental illness and the potential for repurposing existing medications, such as statins and GLP1 receptor agonists, to treat patients who don't respond to conventional therapies. Overall, Dr. Riccardo is a passionate educator in the field of psychiatry who is always looking at these disorders from an embodied perspective where the mind is not separate from the body. Note: When discussing ways in which compounds may enter the brain, I used the term "circumventricular brain regions" when the most appropriate way to describe it is through "circumventricular organs (CVOs). This might be too pedantic, but in Science, terminology is very important. Dr. Riccardo's work and papers discussed: GLP-1 Paper: http://doi.org/10.1038/s44220-025-00390-x Statin Paper: DOI: 10.1016/j.jad.2022.05.113 Creatine Paper: http://doi.org/10.1016/j.euroneuro.2024.10.004 Follow Dr.Riccardo's work: https://x.com/rdegiorgi https://orcid.org/0000-0001-5984-8696 Chapters: 0:00 Intro 2:14 Dr.Riccardo's research 4:07 Treatment Resistance in Psychiatry 8:07 Anhedonia and Depression 9:16 Side effects of psychiatric medications 13:43 Ketogenic diet and metabolic interventions 18:20 Do we need to target the brain to heal it? 22:45 Blood-Brain barrier 25:29 GLP-1 RAs and Anhedonia 29:35 Statins & Depression 33:24 Creatine Monohydrate 35:25 Medication and Increased Suicidality 41:06 Stigma and Perceived Uniqueness of Psychiatry 46:03 Biggest Challenges in Psychiatry 49:48 Problems in Science 51:57 Science Denial 52:50 Tips for those struggling #glp1medication #mentalhealth #metabolichealth #ozempic #psychiatry #psychology
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GLP-1 medications target insulin resistance, providing hope for reversing metabolic disease with lifestyle changes. #GLP1 #MetabolicHealth #InsulinResistance #DiabetesReversal #FunctionalMedicine #HealthTransformation - The information provided in this video is for informational purposes only and is not a substitute for professional medical advice. Always consult your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment. - The content in this video does not create a doctor-patient relationship. The presenter is a Doctor of Chiropractic (DC), not a Medical Doctor (MD). The information should not be construed as medical advice from an MD. - Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. - By watching this video, you agree not to use the content as medical advice to treat any medical condition in yourself or others. The presenter and any affiliates are not responsible for any damages arising from the use of the information provided.
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00:00 - GLP-1 Medications: Why Weight Comes Back After You Stop Wegovy & Zepbound 04:14 - Weight Loss Drugs: Study Reveals Significant Weight Regain After Stopping Medication 05:51 - Weight Regain After Stopping Anti-Obesity Drugs: What You Need to Know | Study Explained 1. GLP-1 Medications: Why Weight Comes Back After You Stop Wegovy & Zepbound GLP-1 medications like Wegovy and Zepbound are proven to help with significant weight loss and manage type 2 diabetes. But what happens when you stop taking them? In this video, we break down the latest research showing that most people regain weight quickly—sometimes within just 2 months—after stopping GLP-1s. Top experts explain why this doesn't mean the drugs failed, but highlights obesity as a chronic disease that requires ongoing management. Key points covered include: • Why GLP-1s help with weight loss and appetite control • What recent studies reveal about the speed and extent of weight regain after stopping • Comparison to stopping medications for diabetes, cholesterol, and blood pressure • Why healthy habits are important, but may not fully prevent rebound weight gain • Medical advice on who should take (or stop) GLP-1s and why lifelong management may be necessary If you're considering starting or stopping GLP-1s, this video provides essential facts and expert guidance to support your weight management journey. Keywords: GLP-1, Wegovy, Zepbound, weight regain, weight loss medication, diabetes, obesity, semaglutide, tirzepatide, stop GLP-1, rebound weight, chronic disease, expert advice 2. Weight Loss Drugs: Study Reveals Significant Weight Regain After Stopping Medication A new study published in BMC Medicine reveals that patients using weight loss drugs like Ozempic and Wegovy may experience significant weight regain within weeks of discontinuing the medication. The research, a review of 11 clinical trials, found a broad trend of weight rebound after medication courses concluded. Significant periods of weight regain were observed at eight, 12, and 20 weeks after stopping the anti-obesity medications. The analysis revealed that the weight rebound typically continued for an average of 20 weeks before stabilizing. Researchers suggest that factors such as the specific medication taken and the consistency of lifestyle changes influence the extent of weight regain, calling for further long-term studies. 3. Weight Regain After Stopping Anti-Obesity Drugs: What You Need to Know | Study Explained A recent study published in BMC Medicine reveals that weight regain begins just 8 weeks after stopping anti-obesity medications like semaglutide, liraglutide, and orlistat. But does this mean these drugs are ineffective? In this video, we break down the key findings of the study, including: - When weight regain starts and how long it continues - Which factors influence weight regain (BMI, drug type, lifestyle) - The long-term benefits of these medications despite weight regain - Real-world effectiveness vs. clinical trial results Whether you're considering anti-obesity medications or just curious about the science behind weight loss, this video provides valuable insights. Stay informed and make better decisions about your health! Keywords: weight regain, anti-obesity drugs, semaglutide, liraglutide, orlistat, GLP-1 agonists, obesity treatment, weight loss, clinical trials, health, wellness
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