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Welcome back to the CardioNerds Cardiovascular Prevention Series, where we are continuing our discussion of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs). This class of medications is becoming a household name, not only for their implications for weight loss but also for their effect on cardiovascular disease. CardioNerds Dr. Ty Sweeney (CardioNerds Academy Faculty Member and incoming Cardiology Fellow at Boston Medical Center), Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at Johns Hopkins Hospital), and special guest Dr. Franck Azobou (Cardiology Fellow at UT Southwestern) sat down with Dr. Darren McGuire (Cardiologist at UT Southwestern and Senior Editor of Diabetes and Vascular Disease Research) to discuss important trial data on GLP-1 RAs in patients with heart disease, as well as recent professional society guidelines on their use. Show notes were drafted by Dr. Ty Sweeney. Audio editing was performed by CardioNerds Intern student Dr. Diane Masket. If you haven’t already, be sure to check out CardioNerds episode #350 where we discuss the basics and mechanism of action of GLP-1 RAs with Dr. Dennis Bruemmer. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Diving into the Data Patients with diabetes and clinical atherosclerotic cardiovascular disease (ASCVD) or who are at high risk of ASCVD benefit from treatment with a GLP-1 RA. For persons with sufficient ASCVD risk and type 2 diabetes, GLP-1 RAs and SGLT2 inhibitors can, and often should, be used in combination. "Just like we don’t consider ‘and/or’ for the four pillars of guideline-directed medical therapy for heart failure with reduced ejection fraction, we shouldn’t parcel out these two therapeutic options...it should be both.” Setting expectations with your patients regarding injection practices, side effects, and expected benefits can go a long way toward improving the patient experience with GLP-1 RAs. Utilize a multidisciplinary approach when caring for patients on GLP-1 RAs. Build a team with your patient’s primary care provider, endocrinologist, clinical pharmacist, and nurse. “This is really a cardiologist issue. These are no longer endocrinology or primary care drugs. We need to be prescribing them ourselves just like we did back in the nineties when we took over the statin prescriptions from the endocrinology domain...we need to lead the way.” Show notes - GLP-1 Agonists: Diving into the Data For which patients are GLP-1 RAs recommended to reduce the risk of major cardiac events? For patients with type 2 diabetes and ASCVD, starting a GLP-1 RA carries a Class 1, Level of Evidence A recommendation in the most recent ESC and ACC guidelines. For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk. The STEP-HFpEF trial showed that among patients with obesity and HFpEF, once-weekly semaglutide may be beneficial in terms of weight loss and quality of life. The results of the FIGHT and LIVE trials question the utility and safety of liraglutide in treating patients with advanced HFrEF. Of the over 17,000 patients enrolled in the SELECT trial, about 25% had heart failure, of which about one-third had HFrEF. Stay tuned for sub-analyses from that trial for more info! Can we still prescribe GLP-1 Ras in patients with well-controlled T2DM?

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Apple cider vinegar has been used for centuries for its numerous health benefits, including weight management, improved digestion, and boosting overall wellness. In recent years, the popularity of apple cider vinegar gummies has been on the rise as people look for more convenient ways to incorporate this powerful ingredient into their daily routine. One such product that has been gaining attention is Ketorganix ACV Gummies. These delicious gummies are a tasty and simple way to enjoy the benefits of apple cider vinegar without the harsh taste of traditional liquid vinegar.

The Benefits of Ketorganix ACV Gummies

1. Weight Management

Ketorganix ACV gummies may help support weight management by increasing feelings of fullness and reducing appetite. The acetic acid in apple cider vinegar has been shown to promote fat burning and improve metabolism, making it a valuable tool for those looking to shed extra pounds.

Additionally, apple cider vinegar can help stabilize blood sugar levels, preventing spikes and crashes that can lead to cravings and overeating. By maintaining steady blood sugar levels, Ketorganix ACV gummies can support weight management and overall health.

2. Digestive Health

Apple cider vinegar is known for its ability to improve digestion and gut health. The acetic acid in apple cider vinegar helps to promote the growth of beneficial bacteria in the gut, which can aid in digestion and nutrient absorption.

Ketorganix ACV gummies provide a convenient way to support digestive health on a daily basis. By incorporating these gummies into your routine, you can help maintain a healthy gut microbiome and improve overall digestive function.

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Apple cider vinegar is a natural immune booster that can help protect the body against harmful pathogens and bacteria. The anti-inflammatory properties of apple cider vinegar can help reduce inflammation in the body, which is linked to a variety of health issues.

Ketorganix ACV gummies are packed with immune-boosting benefits, making them a valuable addition to your wellness routine. By supporting your immune system with these delicious gummies, you can help protect your body against illness and promote overall health.

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1. Take two gummies daily: For best results, it is recommended to take two Ketorganix ACV gummies every day. These gummies can be taken at any time, with or without food, making it easy to incorporate them into your daily routine.

2. Stay hydrated: It is important to drink plenty of water when taking apple cider vinegar gummies to help flush out toxins and support digestion. Be sure to stay hydrated throughout the day to maximize the benefits of Ketorganix ACV gummies.

3. Enjoy the delicious taste: Ketorganix ACV gummies come in a delicious apple flavor that makes them enjoyable to take. These gummies are a tasty alternative to traditional liquid apple cider vinegar, making it easier to stick to your daily wellness routine.

4. Store in a cool, dry place: To preserve the freshness and potency of Ketorganix ACV gummies, be sure to store them in a cool, dry place away from direct sunlight. This will help maintain the quality of the gummies and ensure you get the maximum benefits from each serving.

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Yes, Ketorganix ACV gummies are free of gluten, dairy, and artificial additives, making them suitable for most dietary restrictions. However, if you have any specific dietary concerns, it is always best to consult with a healthcare professional before adding a new supplement to your routine.

2. Are there any side effects of taking Ketorganix ACV gummies?

While Ketorganix ACV gummies are generally safe for most people to take, some individuals may experience minor side effects such as digestive discomfort or an upset stomach. If you experience any adverse reactions, it is recommended to discontinue use and consult with a healthcare provider.

3. How long does it take to see results from taking Ketorganix ACV gummies?

The speed at which you experience results from taking Ketorganix ACV gummies may vary depending on individual factors such as diet, lifestyle, and overall health. Some people may notice benefits within a few weeks of regular use, while others may take longer to see noticeable changes. It is important to be consistent with taking the gummies to maximize their effectiveness.

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Oral semaglutide is a new medication that has been making waves in the weight loss industry. This groundbreaking drug promises to help individuals achieve significant weight loss results by targeting the brain to reduce appetite and increase feelings of fullness. In this article, we will explore the benefits and usage of oral semaglutide for weight loss, as well as provide valuable information on how this medication can help you on your journey to a healthier and happier life.

How Does Oral Semaglutide Work?

Oral semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs work by mimicking the effects of the naturally occurring hormone GLP-1, which is released in the gut after eating. GLP-1 helps regulate blood sugar levels, promotes weight loss, and reduces appetite. By activating GLP-1 receptors in the brain, oral semaglutide helps control hunger and satiety, leading to reduced food intake and ultimately weight loss.

Unlike other weight loss medications that are taken as injections, oral semaglutide comes in a pill form, making it more convenient and accessible for individuals who may be hesitant to use needles. This oral formulation is designed to withstand the acidic environment of the stomach, allowing the medication to reach the intestines where it can be absorbed into the bloodstream and exert its effects. This novel delivery system has the potential to revolutionize the way weight loss medications are administered and may improve adherence to treatment regimens.

In clinical trials, oral semaglutide has been shown to be effective in promoting weight loss when used in combination with diet and exercise. Participants in these studies experienced significant reductions in body weight compared to those who received a placebo. Additionally, oral semaglutide has been found to improve other markers of health, such as blood sugar control and cholesterol levels. These findings suggest that oral semaglutide may not only help individuals lose weight but also improve overall metabolic health.

Benefits of Oral Semaglutide for Weight Loss

One of the main advantages of oral semaglutide is its ability to target the brain and influence hunger and satiety signals. By acting on the brain’s appetite control centers, oral semaglutide helps individuals feel fuller faster and stay satisfied longer, reducing the urge to overeat. This can lead to decreased calorie intake and result in sustainable weight loss over time.

Another benefit of oral semaglutide is its favorable safety profile. In clinical trials, oral semaglutide has been found to be generally well-tolerated, with the most common side effects being mild gastrointestinal symptoms such as nausea and diarrhea. These side effects are usually transient and diminish over time as the body adjusts to the medication. Compared to other weight loss drugs that may carry more serious risks, oral semaglutide appears to be a safe and effective option for individuals looking to shed excess pounds.

Furthermore, oral semaglutide is not just a weight loss medication but also a potential tool for managing other health conditions. In addition to its effects on body weight, oral semaglutide has been shown to improve glycemic control in individuals with type 2 diabetes. This dual action makes oral semaglutide a valuable treatment option for individuals who may have both weight management and diabetes management goals. By addressing both of these issues simultaneously, oral semaglutide offers a holistic approach to improving overall health and well-being.

Usage of Oral Semaglutide for Weight Loss

Before starting oral semaglutide for weight loss, it is important to consult with a healthcare provider to determine if this medication is appropriate for you. Your healthcare provider will evaluate your medical history, current medications, and overall health status to decide if oral semaglutide is the right choice for you. They will also provide guidance on how to take oral semaglutide correctly and monitor your progress throughout treatment.

Typically, oral semaglutide is taken once daily with or without food. The recommended starting dose is usually low to minimize the risk of gastrointestinal side effects, with the dose gradually increased over time to achieve the desired weight loss outcomes. It is important to follow your healthcare provider’s instructions carefully and not adjust the dose on your own. If you have any questions or concerns about taking oral semaglutide, do not hesitate to reach out to your healthcare provider for guidance.

In addition to taking oral semaglutide, it is essential to adopt healthy lifestyle habits to maximize the benefits of this medication. This includes following a balanced diet, engaging in regular physical activity, getting an adequate amount of sleep, and managing stress effectively. These lifestyle modifications can enhance the weight loss effects of oral semaglutide and improve your overall health and well-being in the long run.

Frequently Asked Questions

1. Is oral semaglutide safe for long-term use?

Yes, oral semaglutide has been found to be safe for long-term use in clinical trials. However, it is essential to continue to monitor your health and discuss any potential concerns with your healthcare provider.

2. Can oral semaglutide be used in combination with other weight loss medications?

It is important to consult with your healthcare provider before combining oral semaglutide with other weight loss medications to avoid potential drug interactions or adverse effects.

3. How soon can I expect to see results with oral semaglutide?

Individual results may vary, but some people may start to see weight loss results within a few weeks of starting oral semaglutide. It is important to be patient and consistent with treatment to achieve the best outcomes.

4. Are there any dietary restrictions while taking oral semaglutide?

While there are no specific dietary restrictions with oral semaglutide, it is important to follow a healthy and balanced diet to support your weight loss goals.

5. What should I do if I experience side effects while taking oral semaglutide?

If you experience any side effects while taking oral semaglutide, it is important to notify your healthcare provider. They can provide guidance on how to manage these side effects or adjust your treatment plan accordingly.

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