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Ericka L. Adler, J.D., a shareholder and manager of the health care group at Roetzel & Andress, joins the show to discuss the hidden risks of prescribing GLP-1 medications — like semaglutide and tirzepatide — that physicians need to know, from ensuring informed consent to navigating long-term safety data. Music Credits: After Hours by Yigit Atilla - stock.adobe.com (http://stock.adobe.com/) Relaxing Lounge by Classy Call me Man - stock.adobe.com (http://stock.adobe.com/) COCKTAIL by Mythical Audio - stock.adobe.com (http://stock.adobe.com/) Editor's note: Episode timestamps and transcript produced using AI tools. **Introduction and Overview (00:00:00)** Brief mention of compliance issues and the evolving legal landscape for prescribing GLP-1 drugs. **Podcast Introduction (00:00:29)** Host introduces the episode, speakers, and main topics: legal risks, informed consent, and safety data for GLP-1 drugs. **Guest Introduction (00:01:05)** Introduction of EricKa Adler and the focus on GLP-1 drug risks. **Liability Risks for Prescribing GLP-1 Drugs (00:01:19)** Discussion of primary legal risks, compliance with state and federal laws, and proper office setup. **Off-Label Use Legal Concerns (00:02:49)** Explains legal concerns with off-label prescribing and how to mitigate risks through documentation and informed consent. **Informed Consent Specifics for GLP-1 Drugs (00:05:53)** Importance of tailored, robust informed consent forms for GLP-1 drugs, especially for off-label use. **Compounded Versions and Legal Risks (00:07:57)** Legal risks of prescribing compounded GLP-1 drugs, including contamination, misbranding, and advertising issues. **Insurance Denials and Prior Authorizations (00:11:26)** Challenges with insurance coverage, prior authorizations, and evolving insurer policies for GLP-1 prescriptions. **Telemedicine and Prescribing GLP-1 Drugs (00:14:10)** Legal risks and compliance requirements for prescribing GLP-1 drugs via telemedicine, including licensure and administration rules. **Long-Term Safety and Liability Concerns (00:16:59)** Emerging liability concerns regarding long-term safety and adverse effects, and the importance of malpractice coverage. **Financial Relationships with Pharmaceutical Companies (00:20:10)** Legal and ethical concerns for physicians with financial ties to GLP-1 drug manufacturers, including anti-kickback laws. **Regulatory Changes and Evolving Landscape (00:21:40)** Recent and anticipated legal or regulatory changes, state vs. federal oversight, and the need for ongoing compliance. **Conclusion and Closing Remarks (00:25:02)** Thanking the guest, closing the episode, and providing subscription information.

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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility. Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity. Sign up for updates about each new episode: https://info.insidetracker.com/longevitybydesign View show notes here: https://blog.insidetracker.com/longevity-by-design-podcast-jens-juul-holst Episode highlights: Introduction: 00:00:00 What is GLP-1: 00:03:00 what is a GLP-1 agonist: 00:04:15 what are the target organs of the GLP-1 agonist?: 00:06:30 what is the effect of the GLP-1 agonist on a diabetic patient? : 00:10:00 What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30 How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30 What is the GLP-1 effect on cognition and dementia: 00:29:00 GLP-1 effect on kidney diseases: 00:32:00 GLP-1 positive effect on fertility: 00:35:00 GLP-1 positive effect on cancer: 00:37:30 Should a patient be on GLP-1 for life: 00:41:00 GLP-1 related side effects: 00:48:00 GLP-1 effect on resting heart rate: 00:52:30 GLP-1 related side effects: 00:48:00 GLP-1 from Lilly vs novo nordisk: 00:55:00 GLP-1 oral versus the injectable: 00:58:00 GLP-1 effect on lifespan: 01:00:30 GLP-1 effect on lifespan: 01:00:30 What led you to become a scientist: 01:03:00 The story of discovering the GLP-1: 01:04:30 How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00 GLP-1 moving from once a day to once a week: 01:16:00 Top tip to improve healthspan: 01:18:00 GLP-1 Agonists: A Game-Changer for Diabetes and Obesity Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management. Beyond Weight Loss: Cardiovascular and Inflammatory Benefits of GLP-1 Dr. Holst emphasizes the additional health advantages of GLP-1 agonists, beyond their effects on diabetes and obesity. These drugs improve cardiovascular outcomes by reducing major adverse events such as heart attacks and strokes. They also decrease systemic inflammation, a common issue in metabolic diseases. Holst points out that GLP-1 therapy’s dual action on vascular health and inflammation positions it as a comprehensive solution for improving long-term health outcomes in patients with diabetes or obesity. The Impact of GLP-1 on Fertility Dr. Holst explores GLP-1’s surprising potential in fertility treatments, particularly for individuals with metabolic-related infertility issues, such as polycystic ovary syndrome (PCOS). He explains that improving metabolism and reducing insulin resistance with GLP-1 therapy can enhance fertility outcomes for both men and women. Although he urges caution due to limited long-term data, Holst notes the promising effects observed in clinical experiences. “If you can ameliorate the metabolism of these individuals, they will immediately become pregnant. And we knew that already. You can even do it with metformin…Once GLP-1s were introduced, it turned out that yes, these people became pregnant.” We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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