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Click Here to Subscribe: http://Bit.ly/ThomasVid Get MY groceries at MY price with Thrive Market: http://ThriveMarket.com/Thomas My Website: http://ThomasDeLauer.com Burn Fat Faster | How to Enter 'Fat-Burning Mode' Quicker (Pre-Fasting Strategy) Study - American Journal of Physiology: Assessed the impact of the macronutrient content of a meal on the postprandial leptin response. 22 young healthy subjects (11 men and 11 women) were given, in a randomized order, an isoenergetic meal [carbohydrate (81%) or fat (79%)] or remained fasting. In both genders, leptin response was higher after the carbohydrate meal than after the fat meal and while fasting. In conclusion, a carbohydrate meal induces higher postprandial leptin levels than an isoenergetic fat meal. https://www.ncbi.nlm.nih.gov/pubmed/10567012 So we know that carbs will increase levels of leptin. However, the following study found that leptin levels need to be low in order for fat burning to take place. So trying to spike your leptin right before a fast could be counterproductive. Leptin & Fat Burning: To keep the human brain supplied with energy when food was scarce, mammals evolved the ability to switch from burning carbohydrates to burning fat in order to preserve skeletal muscle that would otherwise be metabolized and converted to glucose. Scientists long believed that the transition to fat metabolism was instigated solely by a drop in insulin. But a new study identified leptin as a key mediator - during starvation, plasma leptin levels fall, activating a pathway that promotes the breakdown of fat and mediates this critical shift from glucose to fat metabolism. While a drop in insulin also occurs, a decrease in leptin is also necessary for this process to happen. Study Summation: Researchers investigated the rate of carbohydrate and fat metabolism as rats went from a fed to a fasted state. The researchers observed that as the rats fasted, leptin levels decreased and activated a pathway that led to fat burning rather than carb burning. During fasting, the rats' use of stored glucose went down and sugar levels decreased as a result. In turn, levels of insulin and leptin decreased - the rats' bodies then broke down body fat to be turned into ketones for energy. Study – Cell: Researchers had rats fast for 48 hours - plasma non-esterified fatty acid (NEFA), glycerol, and bHB (β-OHB) concentrations increased progressively throughout the fast. Unsurprisingly, the reduction in plasma glucose concentrations that occurs as a fast progresses was accompanied by reductions in plasma insulin concentrations and increases in plasma glucagon concentrations. However, they also found that plasma leptin concentrations decreased by 80% between fed and 48-hr fasted rats. Next researchers specifically investigated the impact of reductions in net hepatic glycogenolysis on rates of endogenous glucose production, plasma leptin concentrations, and activation of the HPA axis. They treated post-absorptive rats fasted for 8, 16, and 48 hour with a small molecule inhibitor of glycogen phosphorylase, which resulted in reductions in plasma glucose and insulin concentrations. This was done as it’s consistent with the negligible contributions that hepatic glycogenolysis would be expected to have on plasma glucose concentrations in the glycogen-depleted state (during prolonged fasting.) Interestingly, the reductions in plasma glucose and insulin concentrations in fasted rats treated with the glycogen phosphorylase inhibitor were associated with reductions in plasma leptin concentrations and increases in HPA axis activity, as reflected by increases in plasma corticosterone and ACTH concentrations in these groups. The researchers next infused rats fasted for 48 hours with leptin and found: Increased leptin levels resulted in the suppression of plasma NEFA, glycerol, β-OHB, and lactate concentrations - suppressed HPA axis activity and plasma corticosterone levels as well. Leptin & Fat Burning: Leptin - corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (cortisol in humans) concentrations. Corticotrophin-releasing hormone is secreted by the paraventricular nucleus of the hypothalamus - Corticotrophin-releasing hormone is given this name because it causes release of adrenocorticotropic hormone from the pituitary gland. Adrenocorticotropic hormone, in turn, travels in the bloodstream to the adrenal glands, where it causes the secretion of the stress hormones. Resources: 1) https://www.diabetes.co.uk/news/2018/jan/drop-in-both-insulin-and-leptin-needed-for-fat-burning-to-occur-90969878.html 2) https://www.cell.com/cell/fulltext/S0092-8674(17)31443-5 3) https://www.ncbi.nlm.nih.gov/pubmed/29307489 4) https://www.ncbi.nlm.nih.gov/pubmed/8717038/ 5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430504/

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From my clinical experience, many patients experiencing significant weight loss (20-40 pounds) on GLP-1s notice facial volume loss 🩵 Visit https://www.mdaire.com/ to shop my SCIENCE-BASED COLLAGEN BOOSTING Skincare Line 🩵 Subscribe to the channel: https://www.youtube.com/@DrStefaniKappel?sub_confirmation=1 #glp1 #weightloss #antiaging Disclaimer: The videos on this Youtube channel are for informational purposes only and are not intended for medical advice or management. Information on this channel should not be used to treat, diagnose or manage medical and/or dermatologic conditions. Please consult with a physician or other medical professional regarding the diagnosis and management for any skin or health related issues.

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For Personalized Diet Plans: WhatsApp - +916284306522 WhatsApp Link - https://bit.ly/32SHzHu Email - [email protected] =========== For Business Enquiries: Email - [email protected] =========== Visit Our Store - https://www.amazon.in/shop/eatmorelosemore =========== Recipes: Ajwain Water - https://youtu.be/Dwi1X4hyuhY Jeera Water : https://www.youtube.com/watch?v=rDInRsMMsHg Smoothie (Apple Peanut Butter) - https://www.youtube.com/shorts/Xeisiw2lW6s Smoothies - https://youtu.be/WOd43t9gQ84 Moong Dal Chilla: https://www.youtube.com/watch?v=tB0i43gUx8c Apple Cider Vinegar - https://amzn.to/3P173GE Kabab : https://www.youtube.com/watch?v=K8r7PIUUQzE Vegetables Oats - https://www.youtube.com/watch?v=bWSPSB1euh4 Grilled Veggies : https://www.youtube.com/watch?v=ghVVIIQwlDM Tomato Zucchini Soup :https://www.youtube.com/watch?v=EEsdJiSwglU Lemon coriander soup: https://youtu.be/Gwe_1igv4HE =========== Subscribe to my English Channel: https://www.youtube.com/@EatmoreLosemore Subscribe to my Hindi Channel: https://www.youtube.com/@LetsGoHealthy =========== FREQUENTLY ASKED QUESTIONS: 1. How to Reduce Bloating - https://youtu.be/C_OVW-an6fE 2. How To Start Weight Loss Journey - https://youtu.be/SKRdzgMhTaA 3. Snacking Options for Hunger Pangs - https://youtu.be/exTllf-dDGY ========== Follow Us On ========== Facebook - https://www.facebook.com/eatmorelosemoreyoutube/ Instagram - https://www.instagram.com/eatmorelosemore/ Twitter - https://twitter.com/Eatmorelosemor1 Website - https://www.dietitiansheena.com/ #EatmoreLosemore Music: https://www.bensound.com This video is only intended for informational purposes. Readers are subjected to use this information at their own risk. This channel doesn’t take any responsibility for any harm, side effects, illness, or any health or skin care problems caused due to the use of our content or anything related to this. The content is offered on an informational basis only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified health provider before making any adjustment to a medication or treatment you are currently using, and/or starting any new medication or treatment. All recommendations are “generally informational” and not specifically applicable to any individual’s medical problems, concerns, and/or needs.

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Today, we're going to explore an exciting and revolutionary topic: hacking GLP-1 through the gut microbiome. We'll uncover how tiny microorganisms in our gut can influence a powerful hormone that plays a critical role in our health. Stay through to the end to learn why popular GLP-1 drugs like Ozempic may not be a wise choice. Let's jump in! GLP-1, or Glucagon-like peptide-1, is a hormone produced in the intestines. It helps regulate blood sugar levels by enhancing insulin secretion, and it also plays a role in controlling appetite. This makes it incredibly important for managing conditions like diabetes and obesity.