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The Downsize Weekly Weigh-In and GLP-1 Nes In this episode of 'The Downsize,' hosts Christopher and Laraine Durham share personal updates on their GLP-1, Zepbound, Mounjaro, Ozempic, Wegovy, tirzepatide, semaglutid journey for weight loss, including their latest weigh-in results and experiences with different medications. They discuss the broader use of GLP-1s in America, citing new statistics and advancements in weight loss medications. Christopher and Laraine talk about their personal experiences with weight loss, their current GLP-1 dosages, and their reasons for losing weight. They also share insights into managing side effects and adjusting dosages. The episode covers exciting research on consumer use of GLP-1 drugs, affordability challenges, and broad support for Medicare coverage of weight loss drugs. They touch on the potential impact of GLP-1 medications on food culture and the grocery industry. Additionally, they highlight Amgen's promising new drug, Meritide, and its potential advantages over existing GLP-1 options. The episode concludes with a mention of various topics related to weight loss, health, and GLP-1 medication impacts, along with acknowledgment of their growing subscriber community. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store/ DOWNSIZED WEBSITE: https://thedownsized.org/ Start your weight loss journey today! We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. Barbs site: https://healthatanycost.com/ The Atlantic story: https://www.theatlantic.com/magazine/archive/2024/06/ozempic-obesity-epidemic-weight-loss-debate/678211/ 00:00 Welcome to The Downsize: GLP-1s and Weight Loss News 00:45 Our Weight Loss Journey: Updates and Insights 01:32 Exploring GLP-1 Medication Options and Personal Experiences 04:09 Life Updates: Moving, Fasting, and Health Observations 07:22 Weight Watchers Journey: Goals, Challenges, and Why We Do It 14:35 Looking Ahead: Conferences, Speaking Engagements, and Family Milestones 16:52 GLP-1 Usage in America: Statistics, Costs, and Medicare Coverage 19:27 Exploring Weight Loss Medications and Personal Experiences 19:54 Weight Watchers Meetings: A Personal Story 21:01 Addressing Medication Anxieties and Long-Term Effects 23:56 Noom's Fitness Program for GLP-1 Users 27:56 Vitamin Shop's Tele-Health Service for Weight Management 29:54 Inspiring Weight Loss Journey: Barb Herrera's Story 32:22 Amgen's New Drug Venture: A Game Changer in Obesity Treatment? 37:44 Closing Thoughts and the Importance of Hydration

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Rosie O’Donnell surprised fans in May 2025 with an uplifting update on her weight loss journey, attributing her success to the medication Mounjaro. This injectable drug, known for its effectiveness in treating diabetes, has also emerged as a popular option for weight loss, sharing similarities with Ozempic and Wegovy. O’Donnell proudly showcased her transformation on Instagram, stating, “I can’t believe this is me now,” and revealed that her weight loss was a bonus benefit of her diabetes treatment. In March 2025, she shared with her TikTok followers her progress since relocating to Ireland, mentioning that she had lost significant weight partly due to cooking for herself and her child. O’Donnell expressed her astonishment at her new size, noting her shift from an XL to a large. Other celebrities have also opened up about their experiences with Mounjaro. Whoopi Goldberg discussed her journey on The Kelly Clarkson Show, where she revealed she had lost the equivalent of “almost two people” thanks to the medication. Goldberg highlighted how gradual weight gain can catch individuals off guard, prompting a moment of realization. Comedian Amy Schumer shared her positive experience with Mounjaro on Instagram, contrasting it with her earlier struggles using Wegovy. Schumer explained how her clinicians also addressed her perimenopausal symptoms, resulting in increased energy and improved well-being. Meghan Trainor and her husband, Daryl Sabara, announced in April 2025 that they had both started using Mounjaro after the birth of their son, choosing it for its reportedly fewer side effects. Trainor emphasized the importance of portion control alongside their medication usage. Scott Disick candidly discussed his weight loss journey on The Kardashians, responding to rumors about Mounjaro. He expressed no shame in using the drug, stating that he would have resorted to any method to manage his weight during tougher times. Finally, former reality star Renee Graziano credited Mounjaro for her 52-pound weight loss, sharing her struggles with body image and the journey toward self-acceptance. Graziano encouraged others by saying, “If I can do it, you can do it! It’s all possible!”

Part 2 How To Maintain Weightloss After Stopping Glp1 Medications

Are you struggling to lose weight and considering using weight loss pills to help you achieve your goals? With so many products on the market making bold claims, it can be overwhelming to determine which ones actually work. In this comprehensive guide, we will explore some of the most effective weight loss pills that have been scientifically proven to aid in weight loss.

1. Garcinia Cambogia

Garcinia Cambogia is a popular weight loss supplement that is derived from a tropical fruit of the same name. It contains a compound called hydroxycitric acid (HCA) that has been shown to inhibit the formation of fat in the body and suppress appetite. Studies have suggested that Garcinia Cambogia can help with weight loss by boosting fat-burning and reducing calorie intake.

When choosing a Garcinia Cambogia supplement, look for one that contains at least 50% HCA and is free from fillers or artificial ingredients. It is recommended to take Garcinia Cambogia supplements 30-60 minutes before meals to maximize its effects.

It is important to note that Garcinia Cambogia supplements should be used in conjunction with a healthy diet and exercise regimen for best results. While Garcinia Cambogia can aid in weight loss, it is not a miracle solution and should be used as part of a comprehensive weight loss plan.

2. Green Tea Extract

Green tea extract is another popular weight loss supplement that has been shown to have numerous health benefits, including aiding in weight loss. Green tea contains antioxidants called catechins, which have been found to increase metabolism and promote fat burning.

Studies have suggested that green tea extract can help with weight loss by increasing energy expenditure and fat oxidation. Green tea extract is also known to have appetite-suppressing effects, making it a great addition to a weight loss regimen.

When choosing a green tea extract supplement, look for one that is standardized to contain a high concentration of catechins, such as EGCG. It is recommended to take green tea extract supplements with meals to maximize its effects.

3. Conjugated Linoleic Acid (CLA)

Conjugated Linoleic Acid (CLA) is a type of fatty acid that is found naturally in meat and dairy products. It has been shown to have numerous health benefits, including aiding in weight loss. CLA works by increasing the body’s metabolism, reducing appetite, and promoting the breakdown of fat stores.

Studies have suggested that CLA can help with weight loss by reducing body fat and preserving lean muscle mass. CLA supplements are available in various forms, including softgels and powders.

When choosing a CLA supplement, look for one that is derived from natural sources and is free from artificial ingredients. It is recommended to take CLA supplements with meals to maximize its effects.

4. Caffeine

Caffeine is a natural stimulant that is found in coffee, tea, and various weight loss supplements. It has been shown to increase metabolism, enhance fat oxidation, and improve exercise performance. Caffeine can also suppress appetite, making it a popular ingredient in many weight loss products.

Studies have suggested that caffeine can help with weight loss by increasing energy expenditure and fat burning. However, it is important to consume caffeine in moderation and be mindful of potential side effects, such as jitteriness and insomnia.

When choosing a caffeine supplement, look for one that is derived from natural sources and is free from added sugars or artificial ingredients. It is recommended to consume caffeine supplements in the morning or before workouts to maximize its effects.

5. Orlistat

Orlistat is a prescription weight loss medication that works by blocking the absorption of fat in the intestines. It is approved by the FDA for long-term use and has been shown to be effective in promoting weight loss when used in conjunction with a reduced-calorie diet.

Studies have suggested that Orlistat can help with weight loss by reducing the amount of fat absorbed from the diet and promoting greater weight loss compared to diet and exercise alone. Orlistat is available in both prescription and over-the-counter formulations.

It is important to consult with a healthcare provider before using Orlistat to determine if it is a suitable option for you. While Orlistat can aid in weight loss, it is not a magic solution and should be used as part of a comprehensive weight loss plan.

Summary and FAQ

Overall, there are several weight loss pills and supplements that have been shown to be effective in aiding weight loss. It is important to choose supplements that are backed by scientific research and are free from harmful ingredients. Additionally, weight loss pills should be used in conjunction with a healthy diet and exercise regimen for best results.

FAQ:

1. Are weight loss pills safe to use? While many weight loss pills are safe when used as directed, it is important to consult with a healthcare provider before starting any new supplement regimen. Some weight loss pills may interact with medications or have potential side effects.

2. How long does it take to see results from weight loss pills? The timeline for seeing results from weight loss pills can vary depending on the individual and the specific supplement being used. It is important to be patient and consistent with your weight loss regimen for best results.

3. Can I use multiple weight loss pills at once? It is not recommended to use multiple weight loss pills at once without consulting with a healthcare provider. Mixing different supplements can increase the risk of side effects and may not necessarily lead to greater weight loss.

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Nate Sann, NP, with Advanced Surgical Partners of Virginia and HCA Virginia's Parham Doctors' Hospital, discusses common weight loss medications associated with medical weight loss plans and their usage.