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Discover the powerful link between diet and mental health in this deep dive. It’s not nearly as simple as most people think. Learn six different ways that your food choices can impact mood, energy, and even severe mental health conditions. From nutrient deficiencies to the Mediterranean and ketogenic diets, I unpack the science of food for brain health. Don’t miss this transformative guide to eating for your mind! Read more about this topic in our Brain Energy article: https://newsletter.brainenergy.com/the-role-of-diet-in-mental-health-a-complex-web-of-mechanisms/ Timestamps 00:00 - Intro 01:13 - Nutrients 02:27 - Food Sensitivities 03:00 - Harmful Substances 04:24 - Mediterranean Diet 06:41 - Ketogenic Diet 08:36 - Gut-Brain Connection Dietary interventions have significant potential as a transdiagnostic treatment for neuropsychiatric disorders in Epilepsy, Bipolar Disorder, Major Depressive Disorder (MDD), Schizophrenia, Autism Spectrum Disorder (ASD), Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis (ALS), Traumatic Brain Injury (TBI), Migraine, Anxiety Disorders, Stress-Related Disorders, Multiple Sclerosis (MS). Studies and mentioned: Sapien Labs report looks at the impact of ultra-processed food on mental wellbeing: https://sapienlabs.org/whats_new/report-out-from-sapien-labs-examines-impact-of-ultra-processed-food-on-mental-wellbeing/ Diets and Disorders: Can Foods or Fasting Be Considered Psychopharmacologic Therapies?: https://www.psychiatrist.com/jcp/can-foods-or-fasting-be-psychopharmacologic-therapies/ SMILES Trial: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0791-y PREDIMED Study: https://www.nejm.org/doi/full/10.1056/NEJMoa1800389?query=featured_home The Ketogenic Diet as a Transdiagnostic Treatment for Neuropsychiatric Disorders: Mechanisms and Clinical Outcomes:https://link.springer.com/article/10.1007/s40501-024-00339-4 I hope this video answered some of your questions about how food and dietary interventions can impact and improve mental health. #mentalhealth #diet #food #mentalhealtheducation #gutbrainconnection #ketogenicdiet #mediterraneandiet #brainenergy I am a Harvard psychiatrist and researcher working at the interface of metabolism and mental health. I am the Founder and Director of the Metabolic and Mental Health Program and the Director of the Department of Postgraduate and Continuing Education at McLean Hospital and an Assistant Professor of Psychiatry at Harvard Medical School. For almost 30 years, I have held administrative, educational, research, and clinical roles in psychiatry at McLean and Harvard. I have been pioneering the use of the medical ketogenic diet in the treatment of psychiatric disorders—conducting research in this area, treating patients, writing, and speaking around the world on this topic. Most recently, I have proposed that mental disorders can be understood as metabolic disorders affecting the brain, which has received widespread recognition in both national and international media outlets. For more information: Brain Energy https://brainenergy.com/ Chris Palmer, M.D. https://www.chrispalmermd.com/ @chrispalmermd https://www.instagram.com/chrispalmermd @chrispalmermd https://x.com/ChrisPalmerMD

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Obesity is a major public health concern worldwide, with millions of individuals struggling to lose weight and improve their overall health. Many have turned to medications to aid in their weight loss journey, with semaglutide emerging as a promising option. Semaglutide is a medication originally used to treat type 2 diabetes but has recently been approved by the FDA for chronic weight management. Understanding the mechanism of action behind how semaglutide promotes weight loss can provide valuable insight into its effectiveness and guide individuals considering this option.

Activation of GLP-1 Receptors

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the action of GLP-1, a hormone that is naturally produced in the body. When semaglutide binds to GLP-1 receptors, it activates various pathways in the brain and gastrointestinal tract that help regulate appetite, food intake, and energy expenditure. By stimulating these receptors, semaglutide helps to decrease hunger and increase feelings of fullness, making it easier for individuals to adhere to a calorie-restricted diet.

Furthermore, GLP-1 receptor activation has been shown to slow down gastric emptying, which can contribute to increased satiety and reduced food intake. This delay in gastric emptying, combined with the appetite-suppressing effects of semaglutide, can lead to a decrease in overall caloric intake and promote weight loss over time.

Overall, the activation of GLP-1 receptors by semaglutide plays a crucial role in promoting weight loss by reducing appetite, increasing feelings of fullness, and slowing down digestion, all of which contribute to a negative energy balance and subsequent weight reduction.

Regulation of Blood Sugar Levels

In addition to its effects on appetite and food intake, semaglutide also plays a role in regulating blood sugar levels, which can indirectly impact weight loss. By mimicking the action of GLP-1, semaglutide stimulates the release of insulin from the pancreas in response to meals, helping to reduce blood sugar levels. This insulin response not only improves glycemic control in individuals with diabetes but also plays a role in reducing cravings for high-calorie, sugary foods.

Furthermore, the regulation of blood sugar levels by semaglutide can help prevent insulin resistance, a common metabolic complication associated with obesity. By improving insulin sensitivity and glucose utilization, semaglutide can promote the uptake of glucose into cells for energy production, rather than its storage as fat. This metabolic shift can further support weight loss efforts and improve overall metabolic health.

Overall, the regulation of blood sugar levels by semaglutide contributes to its weight loss effects by reducing cravings for unhealthy foods, improving insulin sensitivity, and promoting the utilization of glucose for energy production, rather than fat storage.

Impact on Metabolic Rate

Another mechanism by which semaglutide promotes weight loss is through its impact on metabolic rate, or the rate at which the body burns calories for energy. Studies have shown that GLP-1 receptor agonists like semaglutide can increase thermogenesis, the production of heat by the body, which requires energy and can contribute to calorie expenditure.

By increasing thermogenesis, semaglutide can help individuals burn more calories throughout the day, even at rest, which can support weight loss efforts by creating a calorie deficit. This increase in metabolic rate can be particularly beneficial for individuals with a slow metabolism or those who have difficulty losing weight with diet and exercise alone.

Overall, the impact of semaglutide on metabolic rate contributes to its weight loss effects by increasing calorie expenditure, promoting the utilization of stored energy, and supporting overall metabolic health. This mechanism, in combination with other effects of semaglutide, can help individuals achieve sustainable and long-term weight loss.

Safety and Efficacy

It is important to note that while semaglutide has shown promising results in promoting weight loss, it is not without risks and potential side effects. Common side effects of semaglutide may include nausea, vomiting, diarrhea, and constipation, which can affect individuals’ quality of life and adherence to treatment. Additionally, there have been concerns about the potential long-term effects of semaglutide on cardiovascular health, pancreatitis, and thyroid cancer, although more research is needed to fully understand these risks.

Despite these potential risks, semaglutide has been shown to be an effective and well-tolerated medication for weight loss in clinical trials. Studies have demonstrated significant reductions in body weight, improvements in metabolic parameters, and overall health benefits in individuals using semaglutide for weight management. However, it is essential for individuals considering semaglutide to discuss the potential risks and benefits with their healthcare provider and closely monitor for any adverse effects during treatment.

In conclusion, semaglutide offers a promising option for individuals struggling with obesity and needing additional support for weight loss. By understanding the various mechanisms through which semaglutide promotes weight loss, individuals can make informed decisions about incorporating this medication into their weight management regimen. It is essential to consider the potential risks and benefits of semaglutide, work closely with healthcare providers, and adopt lifestyle changes to ensure long-term success in achieving and maintaining weight loss goals.

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In this insightful episode of Inadequate Mother, host Hayley Brown sits down with returning guest Andy Palmer for a candid conversation spanning weight loss drugs, body image, gym confidence, parenting challenges, and societal pressures. Andy bravely shares his personal journey using Mounjaro (a weight loss drug), the psychological struggles around food, and how he’s transforming his health while navigating gym culture. Hayley opens up about the emotional rollercoaster of her daughter preparing to leave for university, the societal pressure mothers face, and why self-acceptance — especially around feelings of inadequacy — is so important. Together they dive into big topics like: - The stigma and science behind weight loss medications - Masculine vs. feminine energy in single parenting - Economic privilege and environmental responsibility - Why younger generations hold the key to future social change - The power of saying things out loud and talking to yourself for mental wellbeing This is a raw, funny, and thoughtful episode that reminds us we’re all figuring it out — and that’s okay. Don’t forget to like, comment, and subscribe for more open, accessible, and real conversations. Follow Hayley on Instagram: @hayleybrown_andco Follow Andy on Instagram: @palmer_j_andy

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