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The Semaglutide Shortage Resolution and Breakthroughs in GLP-1 Medications In this episode of Downsized News, hosts Laraine and Christopher Durham delve into the latest updates and controversies surrounding GLP-1 treatments for obesity and diabetes. The FDA's recent announcement that the semaglutide shortage is over sparks debates and legal challenges, raising questions about the availability of compounded GLP-1 products. Eli Lilly prepares to launch Orforglipron, a new oral GLP-1 pill, as studies highlight the benefits of modest weight loss, including reduced joint stress. The episode also discusses how the rise in GLP-1 usage is impacting the apparel industry, leading to more demand for smaller clothing sizes. Legal concerns are addressed as 38 state attorneys general call for FDA action against counterfeit GLP-1 drugs. Finally, a new study reveals that GLP-1 medications primarily reduce body fat while preserving muscle, offering hope for effective and safe weight loss. Tune in for these and more insights from the world of GLP-1 treatments. BOOK THE DOWNSIZED AT SEA CRUISE: https://thedownsized.org/downsized-at-sea-2025/ DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction and Overview 01:21 FDA Declares Semaglutide Shortage Over 04:46 Eli Lilly's New Oral GLP-1 Pill: Orforglipron 07:31 Study Highlights Weight Loss Benefits for Joint Health 09:39 Fashion Industry Adapts to GLP-1 Weight Loss Trend 14:18 Attorney Generals Address GLP-1 Drug Scams 16:54 New Study on GLP-1 and Muscle Preservation 19:44 Conclusion and Sign-Off
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Dr. Vikram Karnik talks with Dr. Lorraine V. Kalia about the potential role of GLP-1 receptor agonists in neurodegenerative diseases, the current state of research, preclinical evidence, and future directions for GLP-1 agonists. Read the related article in The Lancet. Disclosures can be found at Neurology.org.
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