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Findings from a retrospective trial show GLP-1 medications for moderate peripheral artery disease (PAD) significantly decreased the risk of amputations. Dr Catherine Go (Charleston Area Medical Center, Charleston, WV, US) joins us to discuss outcomes from the largest retrospective trial evaluating the impact of GLP-1 medications for patients with moderate PAD. The study used the TriNetX database to identify 55,000 patients who started medication on a GLP-1 receptor agonist and compared them to 55,000 patients who did not start on a GLP-1 receptor agonist, and the patients were followed for one year. Findings showed that GLP-1 receptor agonist treatment in patients with moderate PAD, including in those without diabetes, was associated with lower rates of cardiac events, limb events, hospital admissions and mortality. Interview Questions: 1. What is the importance behind the retrospective trial? 2. What was the study design and patient population? 3. What were the key findings, and were there any unexpected results? 4. What are the take-home messages for practice? 5. What further research is needed in this area, and what are the next steps? Recorded remotely from Charleston, 2025. Editors: Jordan Rance, Yazmin Sadik Videographers: David Ben-Harosh Support: This is an independent interview produced by Radcliffe Vascular. Visit Radcliffe Vascular: https://www.radcliffevascular.com/ This content is intended for healthcare professionals only. Radcliffe brings medical knowledge, insight and innovation to life for CV clinicians around the world, using our communications & creative expertise, our platforms and connections across the community to help transform theory into practice faster. Like us on Facebook: https://www.facebook.com/radcliffe.vascular/ Follow us on X: https://x.com/radcliffeVASCU

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Polycystic Ovary Syndrome (PCOS) is a complex that affects many women. It is clinically diagnosed by the rotterdam criteria if present with 2 of the 3 symptoms: -Hyperandrogenism is when a woman's testosterone levels are elevated above their normal levels. This can cause increased body and facial hair, oily skin, acne, infertility, increased risk of hair loss and central body fat patterning. -Oligo/Anovulation is an infrequent or lack of ovulation. -Polycystic Ovaries (PCO) is diagnosed using an ultrasound scan image of the ovaries that appear to be polycystic (ovaries containing a high density of partially mature follicles). So you can have PCOS without PCO. Being diagnosed with PCOS doesn’t mean it's the end. These symptoms can be managed and lifestyle changes are the key to have a better quality of life. One of the most common ways is through weight loss (if needed). Women with PCOS may have a harder time losing weight, so acknowledge it, be supportive emotionally and coach beyond just “macros/CICO”.Help them stay on track which will be important to making progress so they can buy into the protocols more with results. PCOS women may have increased markers or risk for cardiovascular disease(CVD) and Type 2 Diabetes (TD2) so generally, practical strategies to improve health and weight loss will improve blood profile/inflammatory markers. Losing even 5-10% of BW can help show improvements in health markers, insulin sensitivity and fertility. Practical Recommendations: -Establish a caloric deficit to create weight loss/fat loss (most important) -Including resistance training and cardiovascular work. A combination is great -Building muscle will create a place for the body to store glycogen and help improve insulin resistance issues. -High protein foods are key. -Carbs that are lower in Glycemic index/load can help. -Choose healthy fat sources and reduce saturated fat intake. -Omega 3 fatty acids & Vitamin D3 has benefits. -Carnitine Supplements (PMID: 26666519) -Inositol/Metformin along with Birth Control (Seek Medical Advice) -There is no special diet but if it’s someone who is overweight & w/PCOS start with the basics to build proper eating/lifestyle habits around healthier food choices,inclusive of an exercise plan they will adhere to. (Refs. In comments) Further reading: *Lyle McDonald: Women’s Book Vol.1 *Martin Mcdonal: MNU PCOS Lecture *Refs: PMID: 23420000 -Moran et al. (2013) PMID: 26464839 -Manizheh et al. (2015) PMID: 29580250 -Yang et al. (2013) PMID: 18930208 -Kotsa et al. (2009) Like, Share & Follow for more. Meal plan, consultation, or coaching: www.varoonseepersadfitness.com

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Understanding the True Keto Diet

The True Keto diet has gained considerable traction in recent years, championed by those seeking weight management, mental clarity, and enhanced energy levels. Rooted in the principles of a ketogenic lifestyle, the True Keto approach emphasizes the consumption of high fats, moderate proteins, and very low carbohydrates. This strategic macronutrient distribution aims to shift the body’s metabolism into a state known as ketosis, where it efficiently burns fat for fuel instead of carbohydrates. One of the most intriguing aspects of the True Keto diet is its foundation in scientific principles, corroborated by various nutritional studies highlighting the benefits of fat-adapted metabolism.

The historical context of the ketogenic diet traces back to 1921, initially formulated for controlling epilepsy in children. However, over the decades it has evolved, with various modifications being explored, including those for weight loss and metabolic health. The True Keto diet, specifically, takes these principles further by implementing a more tailored approach that emphasizes not just low carbohydrate intake, but the quality and origin of the fats and proteins consumed. True Keto advocates argue that not all fats are created equal. For an effective ketogenic lifestyle, incorporating healthy fats from whole food sources such as avocados, nuts, seeds, and olive oil is paramount.

Transitioning to a True Keto lifestyle can initially be challenging, as many individuals need to grapple with the psychological and physiological impacts of such a significant dietary shift. The initial phase, often referred to as the “keto flu,” can include temporary side effects such as fatigue, irritability, or headache as the body adapts to burning fat for energy instead of carbohydrates. Despite these initial challenges, individuals who persevere often report increased stamina, improved cognitive function, and more stable energy levels throughout the day. These benefits, combined with the potential for sustainable weight loss and better blood sugar control, contribute to True Keto’s popularity and adoption across diverse populations.

Core Principles and Guidelines for True Keto

The core philosophy behind the True Keto diet lies in significantly reducing carbohydrate intake while increasing dietary fats. Typically, the macronutrient ratio for True Keto is approximately 70-75% fat, 20-25% protein, and only 5-10% carbohydrates. This composition encourages the body to enter ketosis, wherein it reaches a metabolic state that uses fat as the primary energy source. For individuals following True Keto, this means focusing on wholesome, natural food choices rather than processed alternatives, which often contain hidden sugars and unhealthy fats.

<pTo adhere to the True Keto guidelines effectively, meal planning becomes vital. This entails being diligent about ingredient selection while finding enjoyable recipes that fit within the dietary framework. For example, instead of traditional breakfast foods like cereals or toast, True Keto advocates might opt for omelets prepared with cheese and spinach, complemented with avocado on the side. Lunch and dinner meals could involve salads rich in olive oil, grilled chicken or fatty fish, accompanied by non-starchy vegetables like broccoli or cauliflower. Snacks, too, need thoughtful consideration, often consisting of nuts, cheese, or low-carb vegetables with dip.

<pIt is also critical to stay hydrated and replenish electrolytes while on True Keto since reducing carbohydrate intake can lead to a loss of water weight and electrolytes. Incorporating mineral-rich broth, magnesium, potassium, and sodium-rich foods or supplements can help mitigate these potential side effects. Furthermore, as individuals progress on their keto journey, keeping a keen eye on personal health markers, such as blood glucose levels, waist circumference, and possible nutrient deficiencies, is paramount for long-term success.

Navigating Common Challenges on the True Keto Journey

<pMany individuals embarking on a True Keto diet encounter various challenges that can hinder their progress. One of the most common hurdles is the psychological craving for carbohydrates, which many people have been conditioned to view as comfort food. The transition phase can often provoke cravings, leading to frustration and potential deviations from the diet. Maintaining a positive mindset, along with the support of online communities or keto groups, can facilitate this transition and provide encouragement through shared experiences.

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<pEating out or attending social gatherings can present another obstacle. Many mainstream cuisines rely heavily on carbohydrate-heavy dishes. However, navigating menus is possible with a strategy. Communicating dietary preferences to waitstaff, opting for meals centered around proteins and healthy fats, and even bringing your low-carb dishes to social events can greatly help maintain adherence to the diet. Alternatively, consuming a light snack before attending events can also assuage cravings, making it easier to resist high-carb temptations.

<pLastly, the risk of nutrient deficiencies can arise on a strict keto diet, resulting from limited food variety. It is essential to ensure a well-rounded intake of vitamins and minerals by including an array of nutrient-dense, low-carb vegetables and considering high-quality supplements if necessary. Regularly consulting a healthcare provider or a registered dietitian familiar with ketogenic diets can also help tailor an effective nutritional strategy that encompasses personal health needs and goals.

The Impact of True Keto on Mental and Physical Health

<pThe True Keto diet has been associated with numerous benefits not just for physical health but also for mental clarity and emotional well-being. Those adhering to a ketogenic lifestyle often report heightened focus and cognitive performance, partly due to the brain’s preference for ketones as a clean fuel source. Many practitioners also experience more stable mood levels, fewer anxiety episodes, and an overall sense of well-being due to balanced blood sugar levels and reduced insulin fluctuations. These changes indicate the diet's potential in enhancing mental health, which is an important consideration in today's fast-paced world.

<pFrom a physical health perspective, scientific studies suggest that adopting a ketogenic diet can lead to weight loss, reduced levels of triglycerides, and improved HDL cholesterol levels. Additionally, True Keto has demonstrated promise for various metabolic disorders. For individuals at risk of diabetes or those already diagnosed, True Keto can aid in improving insulin sensitivity and lowering blood sugar levels, fostering an easier management of the condition. Moreover, being in ketosis can promote fat loss, particularly visceral fat, which is twofold beneficial as it contributes to better metabolic health and a decrease in obesity-related comorbidities.

<pWhile many individuals find True Keto effective, it is important to critically assess one’s unique health profile and lifestyle suitability before making significant dietary changes. Individuals with certain conditions, such as pancreatitis, liver disease, or certain hormonal disorders, should approach ketogenic diets with caution and under medical supervision. A nuanced understanding of how True Keto interacts with individual health circumstances is crucial to ensuring a beneficial dietary transformation, as sustainable changes will yield the best long-term results.

Addressing Misconceptions and Frequently Asked Questions About True Keto

<pTrue Keto, like many dietary regimens, is often surrounded by myths and misconceptions. One common misconception is that True Keto leads to unhealthy cholesterol levels. In reality, evidence suggests that adopting a ketogenic diet often results in increased levels of HDL (good cholesterol) and decreased triglycerides. The correlation between dietary fat consumption and cholesterol is complex and can vary significantly from person to person, so focusing on quality fats and individual responses is key.

<pAnother common concern is the misconception that a ketogenic diet is restrictive and unsustainable. While it may seem daunting initially, True Keto embraces a variety of delicious food options. Ingenuity in meal planning, such as exploring different cuisines and experimenting with various ingredients, can offer a satisfying and diverse experience. Furthermore, many find that the increased satiety from higher fat intake helps curb hunger, making it easier to adhere to the diet in the long run.

<pFinally, individuals often worry that True Keto promotes unhealthy eating habits, particularly with regard to processed "keto" foods available in stores. It's critical to remember that mid-level processed foods, even when labeled "keto," do not hold the same nutritional value as whole foods. This emphasizes the importance of prioritizing natural, nutrient-dense ingredients in True Keto practice. Educating oneself about the ingredients in packaged goods and focusing on whole foods lays a solid foundation for maintaining both a healthy and sustainable ketogenic lifestyle.

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Everyone wants a magic hack to burn fat. Here are 5 truths that’ll sting — but actually work. 👇🔥 💥 1. Starvation mode is a myth. You’re not gaining weight because you “ate too little.” You’re gaining because you binge every weekend and don’t track shit. (Study: PMID 12094127 — starvation mode = not real.) 💥 2. Fruit will NOT make you fat. That banana didn’t ruin your fat loss. The 3 tablespoons of peanut butter + random bites while cooking did. Sugar in fruit ≠ added sugar. 💥 3. Cold water baths don’t burn fat. Great for recovery. Mood? Amazing. Fat loss? Not unless it puts you in a calorie deficit. Period. 💥 4. HIIT isn’t “better” than walking. Both burn calories. One just makes you feel like you’re doing more. If you hate HIIT, walk. If you like HIIT, go for it. Fat loss doesn’t care what you pick. 💥 5. You always need a calorie deficit. Not cutting carbs. Not eating “clean.” Not detoxing. CALORIE. DEFICIT. That’s how I lost 25 kg. No secrets. Just science and consistency. 📉🔥 So follow me to get real no bs fat loss advice

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